Predictors of Hyperkalemia Risk after Hypertension Control with Aldosterone Blockade according to the Presence or Absence of Chronic Kidney Disease
Conclusion: Spironolactone was well tolerated by selected CKD patients. The risk of serious hyperkalemia or a significant reduction of eGFR appears to be low. Strict monitoring over the first month of treatment followed by standard surveillance for angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers is suggested.Nephron Clin Pract 2014;128:381-386 (Source: Nephron Clinical Practice)
Source: Nephron Clinical Practice - December 18, 2017 Category: Urology & Nephrology Source Type: research
Therapeutic Advances in the Treatment of Polycystic Kidney Disease
The spectrum of polycystic kidney disease (PKD) comprises a family of inherited syndromes defined by renal cyst formation and growth, progressive renal function loss and variable extrarenal manifestations. The most common form, autosomal-dominant PKD is caused by mutations in one of two genes, PKD1 or PKD2. Recent developments in genomic and proteomic medicine have resulted in the discovery of novel genes implicated in the wide variety of less frequent, recessive PKD syndromes. Cysts are the disease, and overall cystic burden, measured by MRI as total kidney volume, is being established as the best available biomarker of d...
Source: Nephron Clinical Practice - October 25, 2017 Category: Urology & Nephrology Source Type: research
Effects of Sleepiness on Survival in Japanese Hemodialysis Patients: J-DOPPS Study
Sleep disorder and poor sleep quality are common in chronic hemodialysis (HD) patients. They have been claimed as a cause of morbidity and mortality. The relationship between the degree of sleepiness and survival has not been studied. We studied the degree of sleepiness in 1,252 adult HD patients (age ≥20 years) recruited into the Dialysis Outcomes Practice Pattern Study in Japan (J-DOPPS III), using the Japanese version of the Epworth Sleepiness Scale (JESS) questionnaire. Demographic data were presented for three subgroups: low, intermediate, and high JESS score. Cox proportional hazard regre ssion analysis was perform...
Source: Nephron Clinical Practice - October 25, 2017 Category: Urology & Nephrology Source Type: research
The 99mTc-DTPA Urinary Clearance Method May Be Preferable to the Plasma Disappearance Method for Assessing Glomerular Filtration Rate in Diabetic Nephropathy
In this study, we compared urinary and plasma iGFR methodologies in patients with diabetic nephropathy.Methods: A total of 147 patients from 3 sites in the Diabetic Intervention with Vitamins to Improve Nephropathy (DIVINe) trial provided 213 sets of urine and blood collections, at baseline, 18 and 36 months.Results: The mean (with standard deviation) plasma iGFR of 60.7 (24.9) ml/min/1.73 m2 compared to urinary iGFR of 52.0 (28.0) ml/min/1.73 m2 was statistically significant (p value (Source: Nephron Clinical Practice)
Source: Nephron Clinical Practice - October 25, 2017 Category: Urology & Nephrology Source Type: research
Compared Decline of Residual Kidney Function in Patients Treated with Automated Peritoneal Dialysis and Continuous Ambulatory Peritoneal Dialysis: A Multicenter Study
Conclusions: Starting PD patients directly on APD is associated with a faster decline of RKF and a higher risk of developing anuria than doing so on CAPD. This detrimental effect is more marked in patients initiating PD with lower levels of RKF.Nephron Clin Pract 2014;128:352-360 (Source: Nephron Clinical Practice)
Source: Nephron Clinical Practice - October 25, 2017 Category: Urology & Nephrology Source Type: research
Ectopic Expression of Fatty Acid-Binding Protein 4 in the Glomerulus Is Associated with Proteinuria and Renal Dysfunction
We examined the hypothesis that pathological conditions alter the level and localization of FABP4 expression in the kidney, which mediates renal dysfunction.Methods: A total of 112 consecutive patients who underwent renal biopsy were retrospectively enrolled. Expression of FABP4 protein and mRNA in the kidney was examined by immunohistochemistry and in situ hybridization, respectively. The ratio of FABP4-positive area to total area within glomeruli (G-FABP4-Area), urinary protein level (U-Protein), and change in estimated glomerular filtration rate (eGFR) 1 year after biopsy were examined.Results: FABP4 protein and mRNA we...
Source: Nephron Clinical Practice - October 25, 2017 Category: Urology & Nephrology Source Type: research
Correction of Hyper- and Hyponatraemia during Continuous Renal Replacement Therapy
Conclusion: During continuous RRT, the step-wise adjustment of [Na+] of dialysate/replacement fluids offers a safe and reliable method to correct sodium disorders.Nephron Clin Pract 2014;128:394-398 (Source: Nephron Clinical Practice)
Source: Nephron Clinical Practice - October 25, 2017 Category: Urology & Nephrology Source Type: research
Differential Membrane Expression of Toll-Like Receptors and Intracellular Cytokine Induction in Peripheral Blood Monocytes of Patients with Chronic Kidney Disease and Diabetic Nephropathy
Background: Toll-like receptors (TLRs) are key players in the innate immune system whose activation leads to an inflammatory response. Inflammation plays an important role in the pathogenesis of chronic kidney disease (CKD) and diabetes mellitus. The aim of our study was to assess the proinflammatory state of nondialysis CKD patients by evaluating the membrane expression of TLR2 and TLR4 and the intracellular IL-1 β and IL-6 production in response to the ligand Pam3Cys-Ser-(Lys)4 (Pam3CSK4).Methods:85 nondialysis CKD patients [mean estimated glomerular filtration rate: 34 (17-90) ml/min/1.73 m2] were divided in 2 groups: ...
Source: Nephron Clinical Practice - October 25, 2017 Category: Urology & Nephrology Source Type: research
Association of de novo Dipstick Albuminuria with Severe Acute Kidney Injury in Critically Ill Septic Patients
Conclusions: De novo DA within the first 24 h of admission was independently associated with severe AKI in critically ill septic patients. Future studies are required to fully elucidate the utility of DA testing in the early detection and stratification of AKI.Nephron Clin Pract 2014;128:373-380 (Source: Nephron Clinical Practice)
Source: Nephron Clinical Practice - October 25, 2017 Category: Urology & Nephrology Source Type: research
Chronic Kidney Disease in Disadvantaged Populations
Nephron Clin Pract 2014;128:292-296 (Source: Nephron Clinical Practice)
Source: Nephron Clinical Practice - October 25, 2017 Category: Urology & Nephrology Source Type: research
Contents Vol. 128, 2014
Nephron Clin Pract 2014;128:I-VI (Source: Nephron Clinical Practice)
Source: Nephron Clinical Practice - October 25, 2017 Category: Urology & Nephrology Source Type: research
Chronic Kidney Disease in Disadvantaged Populations
(Source: Nephron Clinical Practice)
Source: Nephron Clinical Practice - January 15, 2015 Category: Urology & Nephrology Source Type: research
Association of de novo Dipstick Albuminuria with Severe Acute Kidney Injury in Critically Ill Septic Patients
Conclusions: De novo DA within the first 24 h of admission was independently associated with severe AKI in critically ill septic patients. Future studies are required to fully elucidate the utility of DA testing in the early detection and stratification of AKI. (Source: Nephron Clinical Practice)
Source: Nephron Clinical Practice - January 13, 2015 Category: Urology & Nephrology Source Type: research
Differential Membrane Expression of Toll-Like Receptors and Intracellular Cytokine Induction in Peripheral Blood Monocytes of Patients with Chronic Kidney Disease and Diabetic Nephropathy
Conclusions: Nondialysis CKD patients showed significant alterations in TLR2 and TLR4 membrane expression, and impaired Pam3CSK4-induced cytokine production in monocytes, a phenomenon that is markedly influenced by the presence of diabetes.Nephron Clin Pract (Source: Nephron Clinical Practice)
Source: Nephron Clinical Practice - January 9, 2015 Category: Urology & Nephrology Source Type: research
