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Actin-related protein (Arp) 2/3 complex plays a critical role in the aquaporin-2 exocytotic pathway
Am J Physiol Renal Physiol. 2021 Jun 28. doi: 10.1152/ajprenal.00015.2021. Online ahead of print.ABSTRACTThe trafficking of proteins such as aquaporin-2 (AQP2) in the exocytotic pathway requires an active actin cytoskeleton network, but the mechanism is incompletely understood. Here, we show that the actin-related protein (Arp) 2/3 complex, a key factor in actin filament branching and polymerization, is involved in the shuttling of aquaporin-2 (AQP2) between the trans Golgi network (TGN) and the plasma membrane. Arp2/3 inhibition (using CK-666) or siRNA knockdown blocks vasopressin induced AQP2 membrane accumulation, and i...
Source: American Journal of Physiology. Renal Physiology - June 28, 2021 Category: Physiology Authors: Chen-Chung Steven Liu Pui W Cheung Anupama Dinesh Noah Baylor Theodor C Paunescu Anil V Nair Richard Bouley Dennis Brown Source Type: research
Decreased IFT88 expression with primary cilia shortening causes mitochondrial dysfunction in cisplatin-induced tubular injury
Am J Physiol Renal Physiol. 2021 Aug 2. doi: 10.1152/ajprenal.00673.2020. Online ahead of print.ABSTRACTThe relevance of primary cilia shortening in kidney disease and its pathomechanism are largely unknown. Tubular damage in acute kidney injury (AKI) is strongly associated with mitochondrial dysfunction. Thus, we investigated the interaction between primary cilia and mitochondria in cisplatin-induced AKI mouse models. We observed that the expression of intraflagellar transport 88 (IFT88), a ciliary maintenance protein, was decreased in the renal cortex following tubular damage due to cisplatin-induced AKI. This result was...
Source: American Journal of Physiology. Renal Physiology - August 2, 2021 Category: Physiology Authors: Rie Fujii Sho Hasegawa Hiroshi Maekawa Tsuyoshi Inoue Kentaro Yoshioka Rie Uni Yoichiro Ikeda Masaomi Nangaku Reiko Inagi Source Type: research
