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An Alternative Binding Mode of IGHV3-53 Antibodies to the SARS-CoV-2 Receptor Binding Domain
Cell Rep. 2020 Oct 20;33(3):108274. doi: 10.1016/j.celrep.2020.108274. Epub 2020 Sep 29.ABSTRACTIGHV3-53-encoded neutralizing antibodies are commonly elicited during SARS-CoV-2 infection and target the receptor-binding domain (RBD) of the spike (S) protein. Such IGHV3-53 antibodies generally have a short CDR H3 because of structural constraints in binding the RBD (mode A). However, a small subset of IGHV3-53 antibodies to the RBD contain a longer CDR H3. Crystal structures of two IGHV3-53 neutralizing antibodies here demonstrate that a longer CDR H3 can be accommodated in a different binding mode (mode B). These two classe...
Source: IAVI Rep - October 7, 2020 Category: Infectious Diseases Authors: Nicholas C Wu Meng Yuan Hejun Liu Chang-Chun D Lee Xueyong Zhu Sandhya Bangaru Jonathan L Torres Tom G Caniels Philip J M Brouwer Marit J van Gils Rogier W Sanders Andrew B Ward Ian A Wilson Source Type: research
