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Total 20448 results found since Jan 2013.

Notice of Intent to Publish a Funding Opportunity Announcement for Stephen I. Katz Early Stage Investigator Research Project Grant (R01 Basic Experimental Studies with Human Required)
Notice NOT-OD-23-175 from the NIH Guide for Grants and Contracts
Source: NIH Funding Opportunities (Notices, PA, RFA) - September 6, 2023 Category: Research Source Type: funding

Single Source: Molecular Atlas of Lung Development Program (LungMAP) Phase 3 - Human Tissue Core (U01- Clinical Trial Not Allowed)
The objective of the Molecular Atlas of Lung Development (LungMAP) program is to build a comprehensive molecular and cellular atlas of the human lung to serve as a reference platform to better understand both normal biology and disease pathobiology, and to identify critical cellular components, molecular pathways, and novel therapeutic targets in lung disease. LungMAP is an open access resource integrating multi-scale, high-content, high-resolution information to define lung cells with gene expression, physiological states, 3-dimensional locations, as well as developmental and pathological trajectories.
Source: NIH Funding Opportunities (Notices, PA, RFA) - September 6, 2023 Category: Research Source Type: funding

Single Source: Molecular Atlas of Lung Development Program (LungMAP) Phase 3 - Data Coordinating Center (U24- Clinical Trial Not Allowed)
The objective of the Molecular Atlas of Lung Development (LungMAP) program is to build a comprehensive molecular and cellular atlas of the human lung to serve as a reference platform to better understand both normal biology and disease pathobiology, and to identify critical cellular components, molecular pathways, and novel therapeutic targets in lung disease. LungMAP is an open access resource integrating multi-scale, high-content, high-resolution information to define lung cells with gene expression, physiological states, 3-dimensional locations, as well as developmental and pathological trajectories.
Source: NIH Funding Opportunities (Notices, PA, RFA) - September 6, 2023 Category: Research Source Type: funding

Notice of Change to Award Project Period for PAR-21-153 NINDS Faculty Development Award to Promote Diversity in Neuroscience Research (K01 Clinical Trial Required)
Notice NOT-NS-23-108 from the NIH Guide for Grants and Contracts
Source: NIH Funding Opportunities (Notices, PA, RFA) - September 6, 2023 Category: Research Source Type: funding

Notice of Special Interest (NOSI): Quantum Sensing in Biomedical Applications (SBIR/STRR)
Notice NOT-EY-23-009 from the NIH Guide for Grants and Contracts
Source: NIH Funding Opportunities (Notices, PA, RFA) - September 6, 2023 Category: Research Source Type: funding

Review of the Accuracy of Grants Information for Fiscal Year 2023
Notice NOT-OD-23-168 from the NIH Guide for Grants and Contracts
Source: NIH Funding Opportunities (Notices, PA, RFA) - September 6, 2023 Category: Research Source Type: funding

Notice of Intent to Publish a Funding Opportunity Announcement for NHLBI Program Project Applications (P01 Clinical Trials Optional)
Notice NOT-HL-23-114 from the NIH Guide for Grants and Contracts
Source: NIH Funding Opportunities (Notices, PA, RFA) - September 5, 2023 Category: Research Source Type: funding

Notice to Rescind NOT-HL-23-082: NHLBI Notice of Clarification and Availability of Frequently Asked Questions (FAQs) for RFA-HL-23-008 and RFA-HL-23-009 "NHLBI SBIR Phase IIB Small Market Awards"
Notice NOT-HL-23-115 from the NIH Guide for Grants and Contracts
Source: NIH Funding Opportunities (Notices, PA, RFA) - September 5, 2023 Category: Research Source Type: funding

Notice of Change to Award Project Period for PAR-21-234 "NINDS Faculty Development Award to Promote Diversity in Neuroscience Research (K01 Independent Clinical Trial Not Allowed)"
Notice NOT-NS-23-107 from the NIH Guide for Grants and Contracts
Source: NIH Funding Opportunities (Notices, PA, RFA) - September 5, 2023 Category: Research Source Type: funding

The Changing landscape for hAME: Practical experiences from a data analysis of 500 studies
Clin Pharmacol Ther. 2023 Sep 4. doi: 10.1002/cpt.3040. Online ahead of print.ABSTRACTCoincidental with the intensified regulatory and industry focus on the design and conduct of Human Absorption, Metabolism and Excretion (hAME) studies in the past 12 months, we have recently completed our 500th cohort involving radiolabelled test item administration to humans. Here we build upon a recent industry white paper in this journal (1) and share some of our own experiences as a Contract Research Organisation (CRO) based upon collaborations with numerous pharma companies and their differing approaches to design and timing, to add ...
Source: Clinical Pharmacology and Therapeutics - September 4, 2023 Category: Drugs & Pharmacology Authors: John S Kendrick Claudine Oelke Catherine Laing Lee Crossman Ruth Stow Colin Webber Source Type: research

Affinity selection mass spectrometry speeding drug discovery
Drug Discov Today. 2023 Sep 1:103760. doi: 10.1016/j.drudis.2023.103760. Online ahead of print.ABSTRACTAffinity selection mass spectrometry (AS-MS) has gained momentum in drug discovery. This review summarizes how this technology has slowly risen as a new paradigm in hit identification and its potential synergy with DNA encoded library technology. It presents an overview of the recent results on challenging targets and perspectives on new areas of research, such as RNA targeting with small molecules. The versatility of the approach is illustrated and strategic drivers discussed in terms of the experience of a small-medium ...
Source: Drug Discovery Today - September 3, 2023 Category: Drugs & Pharmacology Authors: Renaud Prudent Hugues Lemoine Jarrod Walsh Didier Roche Source Type: research

Single crystal piezoelectric motor operating with both inertia and ultrasonic resonance drives
This study presents a novel piezoelectric motor based on a single crystal material with orthorhombic mm2 symmetry class, in which piezoelectric coupling coefficients in sign and magnitude at transverse directions are different, implying that the value of d32 is positive whilst d31 is negative. The single crystal piezoceramic plate in the shape of a truncated rhombus has three conducting electrodes. While two active electrodes dividing one main surface into two equal sections, the common electrode covers the other main surface uniformly. When a signal is applied between one of the active and the common electrodes, the excit...
Source: Ultrasonics - September 3, 2023 Category: Physics Authors: B ülent Delibas Burhanettin Koc Source Type: research

Affinity selection mass spectrometry speeding drug discovery
Drug Discov Today. 2023 Sep 1:103760. doi: 10.1016/j.drudis.2023.103760. Online ahead of print.ABSTRACTAffinity selection mass spectrometry (AS-MS) has gained momentum in drug discovery. This review summarizes how this technology has slowly risen as a new paradigm in hit identification and its potential synergy with DNA encoded library technology. It presents an overview of the recent results on challenging targets and perspectives on new areas of research, such as RNA targeting with small molecules. The versatility of the approach is illustrated and strategic drivers discussed in terms of the experience of a small-medium ...
Source: Drug Discovery Today - September 3, 2023 Category: Drugs & Pharmacology Authors: Renaud Prudent Hugues Lemoine Jarrod Walsh Didier Roche Source Type: research