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Early retinal inflammatory biomarkers in the middle cerebral artery occlusion model of ischemic stroke.
CONCLUSIONS: This work demonstrates that there is a robust inflammatory response in the eye following MCAO, which may contribute to a worsening of retinal injury and visual impairment. These results mirror what has been observed in the brain after MCAO, suggesting a conserved inflammatory signaling response to ischemia in the central nervous system. Imaging of the eye may therefore serve as a useful non-invasive prognostic indicator of brain injury after MCAO. Future studies are needed to determine whether this inflammatory response is a potential target for therapeutic manipulation in retinal ischemia. PMID: 27293375 ...
Source: Molecular Vision - June 15, 2016 Category: Molecular Biology Tags: Mol Vis Source Type: research