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Rhubarb anthraquinone glycosides against cerebral ischaemia-reperfusion injury in rats by regulating brain-gut neurotransmitters.
In this study, an HPLC-FLD method was established to measure brain-gut neurotransmitters of rats with cerebral ischaemia-reperfusion injury (CIRI), to explore whether the mechanism of RAGs against CIRI is related to the microbiome-gut-brain axis. A SHIMADZU ODS-3 C18 column was employed for chromatographic separation, and 5-hydroxytryptamine (5-HT), 5-hydroxy indole acetic acid (5-HIAA), glutamic acid (Glu), aspartic acid (Asp), and γ-aminobutyric acid (GABA) were determined simultaneously. The results showed that there is a excellent linear relationship (R2 ≥ 0.9990) and a separation degree in the HPLC-FLD method. An...
Source: Biomedical Chromatography : BMC - December 29, 2020 Category: Biomedical Science Authors: Guo Y, Li Q, Yu X, Liang Y Tags: Biomed Chromatogr Source Type: research