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The Sur1-Trpm4 Channel Molecular Bases of Disease
The sulfonylurea receptor 1 (Sur1)-NCCa-ATP channel plays a central role in necrotic cell death in central nervous system (CNS) injury, including ischemic stroke, and traumatic brain and spinal cord injury. Here, we show that Sur1-NCCa-ATP channels are formed by co-assembly of Sur1 and transient receptor potential melastatin 4 (Trpm4). Co-expression of Sur1 and Trpm4 yielded Sur1-Trpm4 heteromers, as shown in experiments with Förster resonance energy transfer (FRET) and co-immunoprecipitation. Co-expression of Sur1 and Trpm4 also yielded functional Sur1-Trpm4 channels with biophysical properties of Trpm4 and pharmacologic...
Source: Journal of Biological Chemistry - February 1, 2013 Category: Chemistry Authors: Woo, S. K., Kwon, M. S., Ivanov, A., Gerzanich, V., Simard, J. M. Tags: Membrane Biology Source Type: research