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Comparative effects of off-pump and multiple cardiopulmonary bypass strategies in coronary artery bypass grafting surgery: protocol for a systematic review and network meta-analysis
This study aims to compare the efficacy and safety of four prevalent revascularisation strategies with/without cardiopulmonary bypass interventions in CABG surgery. Methods and analysis We will search on PubMed, Embase, Cochrane Library, Web of Science and ClinicalTrials.gov for randomised controlled trials and observational cohort studies comparing outcomes of CABG surgery under conventional on-pump, off-pump, on-pump beating heart and minimal extracorporeal circulation technology. All English articles published before 30 November 2022 will be considered. The primary outcome will be 30-day mortality. The secondary outcom...
Source: BMJ Open - June 6, 2023 Category: General Medicine Authors: Tan, J., Gao, S., Li, Y., Li, X., Du, L., Ji, B. Tags: Open access, Anaesthesia Source Type: research

Coronary atherosclerotic burden assessed by SYNTAX scores and outcomes in surgical, percutaneous or medical strategies: a retrospective cohort study
Conclusions Coronary atherosclerotic burden alone was not associated with significantly increased risk of all-cause mortality. The SSII better discriminates the risk of death. Trial registration number ISRCTN66068876.
Source: BMJ Open - September 22, 2022 Category: General Medicine Authors: Scudeler, T. L., Farkouh, M. E., Hueb, W., Rezende, P. C., Campolina, A. G., Martins, E. B., Godoy, L. C., Soares, P. R., Ramires, J. A. F., Kalil Filho, R. Tags: Open access, Cardiovascular medicine Source Type: research

How do type of preoperative P2Y12 receptor inhibitor and withdrawal time affect bleeding? Protocol of a systematic review and individual patient data meta-analysis
Introduction In order to reduce the risk of bleeding in patients on P2Y12 receptor inhibitors presenting for non-emergent coronary artery bypass grafting (CABG), current guidelines recommend a preoperative discontinuation period of at least three, five and seven days for ticagrelor, clopidogrel and prasugrel, respectively, to allow for recovery of platelet function. However, there is still substantial interinstitutional variation in preoperative management and relevant covariates of CABG-related bleeding are largely elusive so far. Methods and analysis We will search PubMed (July 2013 to November 2021) and EMBASE (January...
Source: BMJ Open - March 28, 2022 Category: General Medicine Authors: Schoerghuber, M., Pregartner, G., Berghold, A., Lindenau, I., Zweiker, R., Voetsch, A., Mahla, E., Zirlik, A. Tags: Open access, Anaesthesia Source Type: research

Deriving literature-based benchmarks for surgical complications in high-income countries: a protocol for a systematic review and meta-analysis
This study of secondary data does not require ethics approval. It will be presented internationally and published in the peer-reviewed literature. Results will inform a future quality improvement tool and provide benchmarks of surgical complication rates within HICs. Trial registration International Prospective Register of Systematic Reviews (PROSPERO). Registration number CRD42016037519.
Source: BMJ Open - May 9, 2017 Category: General Medicine Authors: Brindle, M. E., Roberts, D. J., Daodu, O., Haynes, A. B., Cauley, C., Dixon, E., La Flamme, C., Bain, P., Berry, W. Tags: Open access, Health policy Protocol Source Type: research