• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Impact of conventional lipid-lowering therapy on circulating levels of PCSK9: protocol for a systematic review and meta-analysis of randomised controlled trials
Introduction Conventional lipid-lowering agents, including statins, ezetimibe, fibrates, bile acid sequestrants, nicotinic acid, bempedoic acid and Omega-3, are essential to the management of dyslipidaemia. However, these agents have been shown to increase the level of plasma proprotein convertase subtilisin/kexin 9 (PCSK9), a serine protease associated with increased cardiovascular risk. This review aims to investigate the impact of commonly available conventional lipid-lowering agents on circulating PCSK9 levels and lipid profiles. Methods and analysis This protocol is conducted in accordance with the Preferred Reportin...
Source: BMJ Open - September 8, 2022 Category: General Medicine Authors: Luo, J., Huang, T., Xu, R., Wang, X., Yang, Y., Li, L., Zhang, X., Zhang, Y., Yang, R., Wang, J., Yang, H., Ma, Y., Yang, B., Wang, T., Jiao, L. Tags: Open access, Cardiovascular medicine Source Type: research

Comparative efficacy and safety of statins for osteoporosis: a study protocol for a systematic review and network meta-analysis
This study aims to review the literature, ascertaining the relative efficacy and safety of statins for patients with OP using a Bayesian network meta-analysis. Methods and analysis We will systematically search the following databases: MEDLINE, EMBASE, Web of Science, Cochrane Central Register of Controlled Trials, China National Knowledge Infrastructure, Wanfang Database, China Science and Technology Journal Database, Chinese BioMedical Literature Database and preprint servers to include randomised controlled trials that compare different statins for treating OP. Primary outcomes are the incidence of overall fractures an...
Source: BMJ Open - May 17, 2022 Category: General Medicine Authors: Xiong, M., Xue, Y., Zhu, W., Deng, A., Tan, Z., Zhou, G., Xiang, N. Tags: Open access, Diabetes and Endocrinology Source Type: research

Comparative efficacy of different types of acupuncture as adjuvant therapy on carotid atherosclerosis: a protocol for systematic review and network meta-analysis
Introduction Carotid atherosclerosis (CAS) is a disease of the aorta caused by lipid metabolism disorders and local inflammation. Acupuncture combined with traditional western medicine (such as aspirin or atorvastatin) for the treatment of CAS has been widely applied in clinical practice, but there is still a lack of supporting evidence for its efficacy and safety on CAS. Therefore, this systematic review and network meta-analysis (NMA) will summarise the effects of different types of acupuncture treatments on CAS, and a ranking of the therapeutic classes will also be presented, aiming to provide evidence-based medicine fo...
Source: BMJ Open - April 6, 2022 Category: General Medicine Authors: Wu, X., Mo, Q., Yang, Z., Huang, X., Liu, J., Xu, S., Zhang, N., Yang, X. Tags: Open access, Cardiovascular medicine Source Type: research

Statin associated adverse reactions in Latin America: a scoping review
Conclusions We identified differences in the frequency of ADRs in both observational studies and RCTs from LATAM countries. This could be due to the absence of standard definitions and reporting of ADRs as well as differences among the study’s interventions, population characteristics or design. The variability of ADRs and the absence of definitions are similar to studies from other geographical locations. Further placebo-controlled trials and real-world data registries with universal definitions should follow.
Source: BMJ Open - October 1, 2021 Category: General Medicine Authors: Urina-Jassir, M., Pacheco-Paez, T., Paez-Canro, C., Urina-Triana, M. Tags: Open access, Cardiovascular medicine Source Type: research

Tolerability of statin-based management of patients with a history of statin-associated muscle symptoms: protocol for a systematic review
Introduction Statin-associated muscle symptoms (SAMSs) are a major clinical issue in the primary and secondary prevention of cardiovascular events. Current guidelines advise various approaches mainly based on expert opinion. We will lead a systematic review and meta-analysis to explore the tolerability and acceptability and effectiveness of statin-based therapy management of patients with a history of SAMS. We aim to provide evidence on the tolerability and different strategies of statin-based management of patients with a history of SAMS. Methods and analysis We will conduct a systematic review of randomised controlled t...
Source: BMJ Open - August 3, 2021 Category: General Medicine Authors: Villoz, F., Lyko, C., Del Giovane, C., Rodondi, N., Blum, M. R. Tags: Open access, General practice / Family practice Source Type: research

Protocol for a scoping review of post-trial extensions of randomised controlled trials using individually linked administrative and registry data
Introduction Well-conducted randomised controlled trials (RCTs) provide the least biased estimates of intervention effects. However, RCTs are costly and time-consuming to perform and long-term follow-up of participants may be hampered by lost contacts and financial constraints. Advances in computing and population-based registries have created new possibilities for increasing the value of RCTs by post-trial extension using linkage to routinely collected administrative/registry data in order to determine long-term interventional effects. There have been recent important examples, including 20+ years follow-up studies of tri...
Source: BMJ Open - February 16, 2017 Category: Journals (General) Authors: Fitzpatrick, T., Perrier, L., Tricco, A. C., Straus, S. E., Jüni, P., Zwarenstein, M., Lix, L. M., Smith, M., Rosella, L. C., Henry, D. A. Tags: Open access, Epidemiology, Evidence based practice, Health informatics, Health services research, Pharmacology and therapeutics, Research methods Protocol Source Type: research

Feasibility of improving identification of familial hypercholesterolaemia in general practice: intervention development study
Conclusions The intervention is feasible to implement in GP, and facilitates recruitment of patients with raised cholesterol for targeted assessment and identification of FH. Extracting data directly from electronic records could be used to evaluate relevant outcome measures in a future trial.
Source: BMJ Open - May 25, 2016 Category: Journals (General) Authors: Qureshi, N., Weng, S., Tranter, J., El-Kadiki, A., Kai, J. Tags: Open access, Cardiovascular medicine, General practice / Family practice, Health services research Source Type: research

Statin use and risk of liver cancer: an update meta-analysis
Conclusions This meta-analysis suggests that statin is associated with a significant risk reduction of liver cancer when taken daily for cardiovascular event prevention. However, this preventive effect might be overestimated due to the exposure period, the indication and contraindication of statins and other confounders. Statins might be considered as an adjuvant in the treatment of liver cancer.
Source: BMJ Open - September 16, 2014 Category: Journals (General) Authors: Shi, M., Zheng, H., Nie, B., Gong, W., Cui, X. Tags: Open access, Epidemiology, Gastroenterology and hepatology, Oncology Research Source Type: research