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Source: BMJ Open

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Total 1639 results found since Jan 2013.

Development and evaluation of guidelines for prevention of retraumatisation in torture survivors during surgical care: protocol for a multistage qualitative study
Introduction Healthcare professionals working in somatic departments are not trained to recognise signs of torture or provide appropriate healthcare to torture survivors, which may result in retraumatisation during surgical treatment. Methods and analysis This protocol outlines a four-stage qualitative-method strategy for the development and evaluation of guidelines for prevention of retraumatisation of torture survivors during surgical care. The systematic search for literature review in stages 1 and 2 was conducted in August 2019 and March 2021, respectively, using nine databases. The search strategies employed in stage...
Source: BMJ Open - November 5, 2021 Category: General Medicine Authors: Schippert, A. C., Grov, E. K., Dahl-Michelsen, T., Silvola, J., Sparboe-Nilsen, B., Danielsen, S. O., Aaland, M., Bjornnes, A. K. Tags: Open access, Qualitative research Source Type: research

Safety and immunogenicity of inactivated SARS-CoV-2 vaccines in healthy individuals: protocol for a systematic review and meta-analysis
Introduction COVID-19 has spread with high morbidity and mortality worldwide. Many inactivated SARS-CoV-2 vaccines are being tested at various clinical trial stages for the control and prevention of COVID-19. We aim to comprehensively and objectively evaluate the safety and immunogenicity of inactivated SARS-CoV-2 vaccines in healthy individuals through a systematic review and meta-analysis of randomised controlled trials (RCTs). Methods and analysis We will search electronic databases of PubMed, the Cochrane Library, Web of Science and EMBASE for RCTs from inception to 31 December 2021. We will also search conference abs...
Source: BMJ Open - November 5, 2021 Category: General Medicine Authors: Li, M., Yang, X., Jiang, L., Yang, D. Tags: Open access, Infectious diseases, COVID-19 Source Type: research

Protocol for a systematic review and meta-analysis assessing the effectiveness of deprescribing in falls prevention in older people
Introduction One of the known risk factors for fall incidents is the use of specific medications, fall-risk-increasing drugs (FRIDs). However, to date, there is uncertainty related to the effectiveness of deprescribing as a single intervention in falls prevention. Thus, a comprehensive update of the literature focusing on all settings in which older people receive healthcare and all deprescribing interventions is warranted to enhance the current knowledge. Methods and analysis This systematic review protocol follows the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. A systematic search was ...
Source: BMJ Open - November 3, 2021 Category: General Medicine Authors: Seppala, L. J., Kamkar, N., Ryg, J., Masud, T., Daams, J., Montero-Odasso, M. M., Hartikainen, S., Petrovic, M., van der Velde, N., on behalf of the Task Force on Global Guidelines for Falls in Older Adults, Petrovic, Nieuwboer, Vlaeyen, Milisen, Ryg, Ken Tags: Open access, Geriatric medicine Source Type: research

Preparing social workers to address health inequities emerging during the COVID-19 pandemic by building capacity for health policy: a scoping review protocol
This study does not require Research Ethics Board approval as it uses publicly available sources of data.
Source: BMJ Open - November 3, 2021 Category: General Medicine Authors: Ashcroft, R., Lam, S., Kourgiantakis, T., Begun, S., Nelson, M. L. A., Adamson, K., Cadell, S., Walsh, B., Greenblatt, A., Hussain, A., Sur, D., Sirotich, F., Craig, S. L. Tags: Open access, Health policy Source Type: research

Impact of disease-modifying therapies on MRI and neurocognitive outcomes in relapsing-remitting multiple sclerosis: a protocol for a systematic review and network meta-analysis
Introduction Disease-modifying therapies (DMTs) are the mainstay of treatment for relapsing–remitting multiple sclerosis (RRMS). There is established evidence that DMTs are effective at reducing relapse rate and disease progression in RRMS, but there has been less consideration to the synthesis of MRI and neurocognitive outcomes, which play an increasingly important role in treatment decisions. The aim of this systematic review and network meta-analysis is to examine the relative efficacy, acceptability and tolerability of DMTs for RRMS, using MRI and neurocognitive outcomes. Methods and analysis We will search elec...
Source: BMJ Open - November 2, 2021 Category: General Medicine Authors: Lees, S., Dicker, M., Ku, J. E., Chaganti, V., Mew-Sum, M., Wang, N., Smith, A., Oldmeadow, C., Goon, W. L., Bevan, M., Lang, D., Hinwood, M. Tags: Open access, Neurology Source Type: research

Identifying harm reduction strategies for alcohol and drug-use in inpatient care settings and emergency departments: a scoping review protocol
The objective of this review is to identify and synthesise reported harm reduction strategies that have been implemented across inpatient settings and EDs for PWUAD. Methods and analysis This review will include studies from any country and health service reporting on harm reduction strategies implemented in inpatient settings or EDs. The population of interest includes people of any race, gender and age identifying as PWUAD, or individuals who provided care to PWUAD. Studies which describe implementation strategies and barriers and enablers to implementation will be included. Studies published in English, or those availa...
Source: BMJ Open - October 28, 2021 Category: General Medicine Authors: Curran, J. A., Somerville, M., Boulos, L., Caudarella, A., Crowther, D., Johnson, C., Wozney, L., MacPhee, S., Sinclair, D., Elliott Rose, A., Jose, C., Joudrey, M. Tags: Open access, Addiction Source Type: research

Palliative care for people who use substances during communicable disease epidemics and pandemics: a scoping review protocol
Introduction Communicable disease epidemics and pandemics magnify the health inequities experienced by marginalised populations. People who use substances suffer from high rates of morbidity and mortality and should be a priority to receive palliative care, yet they encounter many barriers to palliative care access. Given the pre-existing inequities to palliative care access for people with life-limiting illnesses who use substances, it is important to understand the impact of communicable disease epidemics and pandemics such as COVID-19 on this population. Methods and analysis We will conduct a scoping review and report ...
Source: BMJ Open - October 27, 2021 Category: General Medicine Authors: Buchman, D. Z., Ding, P., Lo, S., Dosani, N., Fazelzad, R., Furlan, A. D., Isenberg, S. R., Spithoff, S., Tedesco, A., Zimmermann, C., Lau, J. Tags: Open access, Palliative care, COVID-19 Source Type: research

Virological measures and factors associated with outcomes, and missing outcome data in HIV clinical trials: a methodological study
Discussion Country source of funding was associated with VL threshold choice and studies with pharmacological interventions had less missing data, which may in part explain heterogeneous virological outcomes across studies. Multiple measures of VL were not associated with missing data. The development of formal guidelines on virological outcome reporting in RCTs is needed.
Source: BMJ Open - October 25, 2021 Category: General Medicine Authors: Youssef, M., Zani, B., Olaiya, O., Soliman, M., Mbuagbaw, L. Tags: Open access, Epidemiology Source Type: research

Role and utility of COVID-19 laboratory testing in low-income and middle-income countries: protocol for rapid evidence synthesis
Introduction Accurate and affordable laboratory testing is key to timely diagnosis and appropriate management of patients with COVID-19. New laboratory test protocols are released into the market under emergency use authorisation with limited evidence on diagnostic test accuracy. As such, robust evidence on the diagnostic accuracy and the costs of available tests is urgently needed to inform policy and practice especially in resource-limited settings. We aim to determine the diagnostic test accuracy, cost-effectiveness and utility of laboratory test strategies for COVID-19 in low-income and middle-income countries. Method...
Source: BMJ Open - October 18, 2021 Category: General Medicine Authors: Ouma, O. K., Ephraim, K., Loyce, N., Namisango, E., Nalugoda, F., Ndagire, R., Wangi, R. N., Kawala, B. A., Katairo, T., Okullo, A. E., Apunyo, R., Semakula, D., Luwambo, A., Kinengyere, A. A., Sewankambo, N., Balinda, S. N., Ocan, M., Obuku, E. A. Tags: Open access, Diagnostics, COVID-19 Source Type: research

Impact of COVID-19 on the digital divide: a rapid review
Conclusions During the early phase of the pandemic in the developed world, familiar difficulties in utilisation of digital healthcare among the elderly and ethnic minorities continued to be observed. This is a further reminder that the digital divide is a persistent challenge that needs to be urgently addressed when considering the likelihood that in many instances these digital technologies are likely to remain at the centre of healthcare delivery.
Source: BMJ Open - October 12, 2021 Category: General Medicine Authors: Litchfield, I., Shukla, D., Greenfield, S. Tags: Open access, Health services research, COVID-19 Source Type: research

Outcomes and complications of peripartum cardiomyopathy: protocol for a systematic review and meta-analysis
This study will report the burden of complications occurring around the time of diagnosis as well as the 6-month or 12-month outcomes of women with PPCM. A summarised description in form of a pooled analysis of across multiple centres, regions and continents would help us to better understand the estimates of complications and outcomes of women with PPCM. Ethics and dissemination As this research is a systematic review of published literature, ethical approval is not required. The results will be reported according to the latest guidelines for Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 stateme...
Source: BMJ Open - October 12, 2021 Category: General Medicine Authors: Hoevelmann, J., Muller, E., Hohlfeld, A., Böhm, M., Sliwa, K., Engel, M. E., Viljoen, C. A. Tags: Open access, Cardiovascular medicine Source Type: research

Sharps injuries and splash exposures among healthcare workers in Arab countries: protocol of a systematic review and meta-analysis
Introduction Sharps injuries, including needlestick injuries and splash exposures, constitute serious occupational health problems for healthcare workers, carrying the risk of bloodborne infections. However, data on such occupational incidents and their risk factors in healthcare settings are scarce and not systematically summarised in the Arab countries. The aim of this study is to conduct a systematic review and meta-analysis to review published literature about sharps injuries and splash exposures of healthcare workers in Arab countries, with the objectives to determine the incidence and/or prevalence of these events, t...
Source: BMJ Open - October 7, 2021 Category: General Medicine Authors: Karkaz, I., Elbarazi, I., Östlundh, L., Paulo, M. S., Sheek-Hussein,, M., Al-Rifai, R. H., Adam, B. Tags: Open access, Occupational and environmental medicine Source Type: research

Nature and extent of intellectual disability nursing research in Ireland: a scoping review to inform health and health service research
Conclusions This review highlights the extent and nature of intellectual disability publications by academic, practitioner or student working in intellectual disability nursing in Ireland together with opportunities for future growth and development. From the findings it is apparent that there is an ongoing need for intellectual disability nurses to define their role across the full trajectory of health provision and to make visible their role in person-family centred support, inclusion, and contributions in health education, health promotion and health management.
Source: BMJ Open - October 6, 2021 Category: General Medicine Authors: Doody, O., Bailey, M. E., Hennessy, T. Tags: Open access, Nursing Source Type: research

Statin associated adverse reactions in Latin America: a scoping review
Conclusions We identified differences in the frequency of ADRs in both observational studies and RCTs from LATAM countries. This could be due to the absence of standard definitions and reporting of ADRs as well as differences among the study’s interventions, population characteristics or design. The variability of ADRs and the absence of definitions are similar to studies from other geographical locations. Further placebo-controlled trials and real-world data registries with universal definitions should follow.
Source: BMJ Open - October 1, 2021 Category: General Medicine Authors: Urina-Jassir, M., Pacheco-Paez, T., Paez-Canro, C., Urina-Triana, M. Tags: Open access, Cardiovascular medicine Source Type: research

Effects of a physiotherapist-led approach based on a biopsychosocial model for spinal disorders: protocol for a systematic review
This study is exempt from ethical approval because it involves publicly available documents. The findings will be submitted for publication in a relevant peer-reviewed journal. PROSPERO registration number CRD42021258071.
Source: BMJ Open - September 28, 2021 Category: General Medicine Authors: Miki, T., Kondo, Y., Kurakata, H., Takebayashi, T., Samukawa, M. Tags: Open access, Rehabilitation medicine Source Type: research