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Sodium-glucose cotransporter-2 inhibitors for improving endocrine and metabolic profiles in overweight and obese individuals with polycystic ovary syndrome: a meta-analysis protocol
Introduction Polycystic ovary syndrome (PCOS) is a heterogeneous reproductive endocrine disorder. Several ongoing trials test sodium-glucose cotransporter-2 (SGLT-2) inhibitors for women with PCOS. However, their effectiveness has not been fully elucidated owing to the lack of high-confidence evidence. Our group agrees with the statement that SGLT-2 inhibition could treat PCOS as it is supported by reports demonstrating the benefits of SGLT-2 inhibition on metabolic status and weight control. Moreover, the functions of chronic inflammation amelioration and cardiovascular system protection make it a more attractive candidat...
Source: BMJ Open - April 25, 2022 Category: General Medicine Authors: Zhang, J., Xing, C., He, B. Tags: Open access, Diabetes and Endocrinology Source Type: research

Protocol for a systematic review assessing the measurement of dietary sodium intake among adults with elevated blood pressure
Introduction Accurate sodium intake estimates in adults with elevated blood pressure are essential for monitoring salt reduction progress and preventing cardiovascular diseases. However, sodium assessments are challenging in this high-risk population because many commonly used antihypertensive drugs alter urinary sodium excretion. Despite the high cost and substantial participant burden of gold-standard 24-hour urine collection, the relative performance of existing spot-urine based equations and dietary self-report instruments have not been well studied in this population, who will benefit from salt restriction. This syste...
Source: BMJ Open - January 3, 2022 Category: General Medicine Authors: Soh, Y. C., Yap, K. H., McGrattan, A., Yasin, S., Reidpath, D., Siervo, M., Mohan, D. Tags: Open access, Public health Source Type: research

Values, preferences and burden of treatment for the initiation of GLP-1 receptor agonists and SGLT-2 inhibitors in adult patients with type 2 diabetes: a systematic review
Conclusions As no evidence for preferences on SGLT-2i was available, only preferences for GLP-1 RA were assessed; however, evidence is still limited for the latter. Studies comparing preferences for GLP1-RA to other glucose-lowering alternatives only included twice daily or once daily injection regimens of GLP-1 RA drugs. According to our findings, once weekly alternatives are widely preferred than the formers. The extent to which patients with type 2 diabetes value reduced adverse cardiovascular and kidney outcomes, weighed benefits against harms and burden of treatment is limited and with very low certainty. PROSPERO re...
Source: BMJ Open - July 9, 2021 Category: General Medicine Authors: Gonzalez-Gonzalez, J. G., Diaz Gonzalez-Colmenero, A., Millan-Alanis, J. M., Lytvyn, L., Solis, R. C., Mustafa, R. A., Palmer, S. C., Li, S., Hao, Q., Alvarez-Villalobos, N. A., Vandvik, P. O., Rodriguez-Gutierrez, R. Tags: Open access, Diabetes and Endocrinology Source Type: research

Sodium intake and blood pressure in children and adolescents: protocol for a systematic review and meta-analysis
Introduction Hypertension is a major risk factor for cardiovascular diseases. In adults, high sodium intake is associated with elevated blood pressure. In children, experimental studies have shown that reducing sodium intake can reduce blood pressure. However, their external validity is limited, notably because the sodium reduction was substantial and not applicable in a real-life setting. Observational studies, on the other hand, allow assess the association between blood pressure and sodium intake across usual levels of consumption. There is also evidence that the association differs between subgroups of children accordi...
Source: BMJ Open - September 20, 2016 Category: Journals (General) Authors: Leyvraz, M., Taffe, P., Chatelan, A., Paradis, G., Tabin, R., Bovet, P., Bochud, M., Chiolero, A. Tags: Open access, Cardiovascular medicine, Nutrition and metabolism Protocol Source Type: research