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Non-erythropoiesis-stimulating agent, non-iron therapies for the management of anaemia: protocol for a scoping review
Introduction Preoperative anaemia is associated with poor postoperative outcomes and is the strongest predictor of allogenic blood transfusion, which contributes further to patient morbidity. Emphasis has been placed on correcting anaemia prior to surgery to mitigate these outcomes. Conflicting evidence exists regarding the benefit of currently recommended interventions. With greater understanding of iron haemostasis and erythropoiesis, novel therapies have been identified. These are at varying stages of development with some demonstrating promising results in patients with chronic kidney disease. It is not known how these...
Source: BMJ Open - April 11, 2022 Category: General Medicine Authors: Devlin, P., Davies, A., Dugan, C., Richards, T., Miles, L. F. Tags: Open access, Anaesthesia Source Type: research

Optimal iron content in ready-to-use therapeutic foods for the treatment of severe acute malnutrition in the community settings: a protocol for the systematic review and meta-analysis
Introduction The current standard of care for children with severe acute malnutrition (SAM) involves using ready-to-use therapeutic food (RUTF) to promote growth; however, the precise formulation to achieve optimal recovery remains unclear. Emerging research suggests that alternative RUTF formulations may be more effective in correcting SAM-related complications such as anaemia and iron deficiency. This systematic review commissioned by the WHO aims to synthesise the most recent research on the iron content in RUTF and related products in the community-based treatment of uncomplicated severe malnutrition in children aged 6...
Source: BMJ Open - March 9, 2022 Category: General Medicine Authors: Imdad, A., Francois, M., Chen, F. F., Smith, A., Tsistinas, O., Tanner-Smith, E., Das, J. K., Bhutta, Z. A. Tags: Open access, Paediatrics Source Type: research