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Temporal profile of adverse drug reactions and associated clinical factors: a prospective observational study in a neonatal intensive care unit
Conclusion ADRs are very common in NICU, with tachycardia and hyperthermia predominant in the first week of hospitalisation and polyuria and hypokalaemia from the third week onwards.
Source: BMJ Open - August 8, 2023 Category: General Medicine Authors: Leopoldino, R. W. D., Marques, D. P., Rocha, L. C., Fernandes, F. E. M., Oliveira, A. G., Martins, R. R. Tags: Open access, Paediatrics Source Type: research

Systematic literature review of adopting eHealth in pharmaceutical care during COVID-19 pandemic: recommendations for strengthening pharmacy services
Conclusion This study revealed the wide adoption of eHealth in PC during the pandemic and the emerging evidence for its importance. Proper adoption of eHealth will help reshape the mode of pharmacy services to ensure continuity, quality and efficiency of care amid the challenges of the pandemic. PROSPERO registration number CRD42022299812.
Source: BMJ Open - November 23, 2022 Category: General Medicine Authors: Cen, Z. F., Tang, P. K., Hu, H., Cavaco, A. C., Zeng, L., Lei, S. L., Ung, C. O. L. Tags: Open access, Public health, COVID-19 Source Type: research

Time series analysis of the incidence of acute upper respiratory tract infections, COVID-19 and the use of antibiotics in Finland during the COVID-19 epidemic: a cohort study of 833 444 patients
Conclusions At the beginning of the epidemic, many people contacted healthcare professionals with relatively mild symptoms, as indicated by the reduced rate of URTI-antibiotics prescriptions. Our findings indicate that health service providers should be prepared for rapid variations in service demand. Securing access of true COVID-19 patients to proper diagnostics, care and isolation measures may help in preventing the spread of the disease.
Source: BMJ Open - January 31, 2022 Category: General Medicine Authors: Niemenoja, O., Taalas, A., Taimela, S., Bono, P., Huovinen, P., Riihijärvi, S. Tags: Open access, Epidemiology, COVID-19 Source Type: research

Clinical prediction models for hospital falls: a scoping review protocol
Introduction Falls remain one of the most prevalent adverse events in hospitals and are associated with substantial negative health impacts and costs. Approaches to assess patients’ fall risk have been implemented in hospitals internationally, ranging from brief screening questions to multifactorial risk assessments and complex prediction models, despite a lack of clear evidence of effect in reducing falls in acute hospital environments. The increasing digitisation of hospital systems provides new opportunities to understand and predict falls using routinely recorded data, with potential to integrate fall prediction ...
Source: BMJ Open - September 13, 2021 Category: General Medicine Authors: Parsons, R., Cramb, S. M., McPhail, S. M. Tags: Open access, Health informatics Source Type: research

Protocol for a scoping review of post-trial extensions of randomised controlled trials using individually linked administrative and registry data
Introduction Well-conducted randomised controlled trials (RCTs) provide the least biased estimates of intervention effects. However, RCTs are costly and time-consuming to perform and long-term follow-up of participants may be hampered by lost contacts and financial constraints. Advances in computing and population-based registries have created new possibilities for increasing the value of RCTs by post-trial extension using linkage to routinely collected administrative/registry data in order to determine long-term interventional effects. There have been recent important examples, including 20+ years follow-up studies of tri...
Source: BMJ Open - February 16, 2017 Category: Journals (General) Authors: Fitzpatrick, T., Perrier, L., Tricco, A. C., Straus, S. E., Jüni, P., Zwarenstein, M., Lix, L. M., Smith, M., Rosella, L. C., Henry, D. A. Tags: Open access, Epidemiology, Evidence based practice, Health informatics, Health services research, Pharmacology and therapeutics, Research methods Protocol Source Type: research

Automatic identification of type 2 diabetes, hypertension, ischaemic heart disease, heart failure and their levels of severity from Italian General Practitioners' electronic medical records: a validation study
Conclusions This study shows that individuals with T2DM, hypertension or IHD can be validly identified in HSD by automated identification algorithms. Automatic queries for levels of severity of the same diseases compare well with the corresponding clinical definitions, but some misclassification occurs. For HF, further research is needed to refine the current algorithm.
Source: BMJ Open - December 8, 2016 Category: Journals (General) Authors: Gini, R., Schuemie, M. J., Mazzaglia, G., Lapi, F., Francesconi, P., Pasqua, A., Bianchini, E., Montalbano, C., Roberto, G., Barletta, V., Cricelli, I., Cricelli, C., Dal Co, G., Bellentani, M., Sturkenboom, M., Klazinga, N. Tags: Open access, Epidemiology, Health informatics, Public health Research Source Type: research

Impact of e-alert for detection of acute kidney injury on processes of care and outcomes: protocol for a systematic review and meta-analysis
Introduction Acute kidney injury (AKI) is a common complication in hospitalised patients. It imposes significant risk for major morbidity and mortality. Moreover, patients suffering an episode of AKI consume considerable health resources. Recently, a number of studies have evaluated the implementation of automated electronic alerts (e-alerts) configured from electronic medical records (EMR) and clinical information systems (CIS) to warn healthcare providers of early or impending AKI in hospitalised patients. The impact of e-alerts on care processes, patient outcomes and health resource use, however, remains uncertain. Met...
Source: BMJ Open - May 4, 2016 Category: Journals (General) Authors: Lachance, P., Villeneuve, P.-M., Wilson, F. P., Selby, N. M., Featherstone, R., Rewa, O., Bagshaw, S. M. Tags: Open access, Intensive care, Renal medicine Protocol Source Type: research