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Source: BMJ Open

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Total 555 results found since Jan 2013.

Quantifying the risk of heart disease following acute ischaemic stroke: a meta-analysis of over 50 000 participants
Conclusions One-third of patients with ischaemic stroke with no cardiac history have more than 50% coronary stenosis and 3% are at risk of developing MI within a year. Our findings provide a reliable quantitative measure of the risk of IHD following AIS in patients with no cardiac history.
Source: BMJ Open - January 20, 2016 Category: Journals (General) Authors: Gunnoo, T., Hasan, N., Khan, M. S., Slark, J., Bentley, P., Sharma, P. Tags: Open access, Cardiovascular medicine, Neurology Research Source Type: research

Mortality and use of psychotropic medication in patients with stroke: a population-wide, register-based study
Conclusions All-cause mortality was higher in patients with stroke and controls treated with benzodiazepines, antidepressants and antipsychotics than in their untreated counterparts. Our findings suggest that care should be taken in the use and prescription of such drugs, and that they should be used in conjunction with adequate clinical controls.
Source: BMJ Open - March 8, 2016 Category: Journals (General) Authors: Jennum, P., Baandrup, L., Iversen, H. K., Ibsen, R., Kjellberg, J. Tags: Open access, Epidemiology, Health services research, Neurology, Rehabilitation medicine Source Type: research

Living in Latvia after stroke: the association between functional, social and personal factors and the level of self-perceived disability--a cross-sectional study
Conclusions Functional, social and personal factors are of similar importance when explaining self-perceived disability in the chronic phase of stroke. Some, but not all, of the factors are modifiable by the healthcare system. Therefore, a complex approach and involvement of medical, social and political systems is needed.
Source: BMJ Open - June 23, 2016 Category: Journals (General) Authors: Berzina, G., Smilskalne, B., Vetra, A., Stibrant Sunnerhagen, K. Tags: Open access, Neurology, Rehabilitation medicine Research Source Type: research

Secondary prevention and cognitive function after stroke: a study protocol for a 5-year follow-up of the ASPIRE-S cohort
Introduction Cognitive impairment is common following stroke and can increase disability and levels of dependency of patients, potentially leading to greater burden on carers and the healthcare system. Effective cardiovascular risk factor control through secondary preventive medications may reduce the risk of cognitive decline. However, adherence to medications is often poor and can be adversely affected by cognitive deficits. Suboptimal medication adherence negatively impacts secondary prevention targets, increasing the risk of recurrent stroke and further cognitive decline. The aim of this study is to profile cognitive f...
Source: BMJ Open - March 27, 2017 Category: Journals (General) Authors: Rohde, D., Williams, D., Gaynor, E., Bennett, K., Dolan, E., Callaly, E., Large, M., Hickey, A. Tags: Open access, Cardiovascular medicine, Epidemiology Protocol Source Type: research

Long-term use benefits of personal frequency-modulated systems for speech in noise perception in patients with stroke with auditory processing deficits: a non-randomised controlled trial study
Conclusions 10-week use of FMs by adult patients with stroke may lead to benefits in unaided speech in noise perception. Our findings may indicate auditory plasticity type changes and require further investigation. Trial registration number Pre-results; NCT02889107.
Source: BMJ Open - April 7, 2017 Category: Journals (General) Authors: Koohi, N., Vickers, D., Warren, J., Werring, D., Bamiou, D.-E. Tags: Open access, Ear, nose and throat/otolaryngology, Neurology Research Source Type: research

Impact of COVID-19 pandemic on haemorrhagic stroke admissions: a systematic review and meta-analysis
Conclusions The number of stroke admissions is lower in the pandemic period compared with the control period. There is a higher rate of haemorrhagic stroke in the pandemic period. Subgroup analysis identifies a significant increase in the occurrence of intracerebral haemorrhage in the pandemic period. Due to limited data and the impact of a single article, the impact of COVID-19 pandemic on subarachnoid haemorrhage is unclear.
Source: BMJ Open - December 14, 2021 Category: General Medicine Authors: You, Y., Niu, Y., Sun, F., Zhang, J., Huang, S., Ding, P., Wang, X. Tags: Open access, Public health, COVID-19 Source Type: research

Impact of a health campaign on Chinese public awareness of stroke: evidence from internet search data
Conclusions The WSD campaign increased internet search activity. These research techniques can be applied to evaluation of other health campaigns. Advancing understanding of public demand will enable tailoring of the campaign and strengthen health management.
Source: BMJ Open - December 14, 2021 Category: General Medicine Authors: Cao, M., Guan, T., Han, X., Shen, B., Chao, B., Liu, Y. Tags: Open access, Public health Source Type: research

Nominal group technique to establish the core components of home-based rehabilitation for survivors of stroke with severe disability
Conclusion The consensus statements highlight the complexity of managing patients with severe stroke disability following discharge from hospital. This study has the potential to support the provision of services for this patient group, providing a benchmark for commissioners and clinicians as well as setting expectations for stroke survivors and their carers. What remains unknown is how many services currently offer this service to patients with severe disability.
Source: BMJ Open - December 2, 2021 Category: General Medicine Authors: Fisher, R. J., Riley-Bennett, F., Russell, L., Lee, C., Sturt, R., Walker, M., Sackley, C. Tags: Open access, Rehabilitation medicine Source Type: research

Evaluation of microalbuminuria as a prognostic indicator after a TIA or minor stroke in an outpatient setting: the prognostic role of microalbuminuria in TIA evolution (ProMOTE) study
Conclusion A risk score comprising age, previous stroke/TIA and microalbuminuria predicts future MACE while identifying those at low risk of a recurrent event. This tool shows promise in the risk stratification of patients to avoid the admission of low-risk patients.
Source: BMJ Open - September 6, 2021 Category: General Medicine Authors: Strain, W. D., Elyas, S., Wedge, N., Mounce, L., Henley, W., James, M., Shore, A. C. Tags: Open access, Medical management Source Type: research

Allogeneic adipose tissue-derived mesenchymal stem cells in ischaemic stroke (AMASCIS-02): a phase IIb, multicentre, double-blind, placebo-controlled clinical trial protocol
Introduction Stroke is a serious public health problem, given it is a major cause of disability worldwide despite the spread of recanalisation therapies. Enhancement of brain plasticity with stem cell administration is a promising innovative therapy to reduce sequelae in these patients. Methods and analysis We have developed a phase IIb, multicentre, randomised, double-blind, placebo-controlled clinical trial protocol to evaluate the safety and efficacy of intravenous administration of allogeneic adipose tissue-derived mesenchymal stem cells (AD-MSCs) in patients with acute ischaemic stroke, concurrently with conventional...
Source: BMJ Open - August 9, 2021 Category: General Medicine Authors: de Celis-Ruiz, E., Fuentes, B., Moniche, F., Montaner, J., Borobia, A. M., Gutierrez-Fernandez, M., Diez-Tejedor, E. Tags: Open access, Neurology Source Type: research

Risk factors for 30-day in-hospital mortality for in-patient with stroke in sub-Saharan Africa: protocol for a systematic review and meta-analysis
Introduction While individual studies have reported on in-hospital stroke mortality rates in sub-Saharan Africa (SSA), the estimates are highly variable and inconclusive, buttressing the need for precise and reliable estimations. To overcome these inconsistencies, a well-structured systematic review and meta-analytical models are necessary. However, to the best of our knowledge, there is no published systematic review and meta-analysis on risk factors for 30-day mortality for in-hospital patients with stroke in SSA. Method and analysis We will include all retrospective and prospective facility-based observational studies ...
Source: BMJ Open - July 23, 2021 Category: General Medicine Authors: Ackah, M., Yeboah, C. O., Ameyaw, L. Tags: Open access, Cardiovascular medicine Source Type: research

Self-care interventions in stroke survivor-caregiver dyads: a protocol for systematic review and meta-analysis
Introduction Stroke is known as one of the leading causes of mortality and disability worldwide. Self-care plays a significant role in improving the quality of life, self-efficacy and many other outcomes of stroke survivors. However, it is a dyadic phenomenon where patient self-care and the caregiver contribution to self-care are inter-related in terms of predictors and outcomes. Currently, there is still no systematic assessment conducted to examine the overall effectiveness of self-care interventions carried out in stroke survivor–caregiver dyads and explore the effect on stroke survivor and/or caregiver outcomes. ...
Source: BMJ Open - December 30, 2021 Category: General Medicine Authors: Wang, W., Lin, B., Mei, Y., Zhang, Z., Zhou, B. Tags: Open access, Nursing Source Type: research

RETurn to work After stroKE (RETAKE) Trial: protocol for a mixed-methods process evaluation using normalisation process theory
Objectives This mixed-method process evaluation underpinned by normalisation process theory aims to measure fidelity to the intervention, understand the social and structural context in which the intervention is delivered and identify barriers and facilitators to intervention implementation. Setting RETurn to work After stroKE (RETAKE) is a multicentre individual patient randomised controlled trial to determine whether Early Stroke Specialist Vocational Rehabilitation (ESSVR) plus usual care is a clinically and cost-effective therapy to facilitate return to work after stroke, compared with usual care alone. This protocol ...
Source: BMJ Open - March 15, 2022 Category: General Medicine Authors: Radford, K. A., McKevitt, C., Clarke, S., Powers, K., Phillips, J., Craven, K., Watkins, C., Farrin, A., Holmes, J., Cripps, R., McLellan, V., Sach, T., Brindle, R., Holloway, I., Hartley, S., Bowen, A., O'Connor, R. J., Stevens, J., Walker, M., Murray, J Tags: Open access, Cardiovascular medicine Source Type: research

Evaluation of a community-based performance arts programme for people who have experienced stroke in the UK: protocol for the SHAPER-Stroke Odysseys study
In this study, we aim to evaluate the implementation, impact and experiences of SO for stroke survivors. Methods and analysis Scaling-up Health Arts Programmes: Implementation and Effectiveness Research (SHAPER)-SO aims to scale-up SO to 75 participants and 47 stakeholders, while simultaneously evaluating the effectiveness and implementation of the programme. The main research aim is to evaluate the implementation, effectiveness, impact and experiences of a community-based performance arts programme (SO for stroke survivors). This mixed-methods study will evaluate the experience and impact of SO on those participating usi...
Source: BMJ Open - March 11, 2022 Category: General Medicine Authors: Estevao, C., Baldellou Lopez, M., Davis, R. E., Jarret, L., Soukup, T., Bakolis, I., Healey, A., Harrington, J., Woods, A., Crane, N., Jones, F., Pariante, C., Fancourt, D., Sevdalis, N. Tags: Open access, Qualitative research Source Type: research

TACTICS - Trial of Advanced CT Imaging and Combined Education Support for Drip and Ship: evaluating the effectiveness of an 'implementation intervention in providing better patient access to reperfusion therapies: protocol for a non-randomised controlled stepped wedge cluster trial in acute stroke
Introduction Stroke reperfusion therapies, comprising intravenous thrombolysis (IVT) and/or endovascular thrombectomy (EVT), are best practice treatments for eligible acute ischemic stroke patients. In Australia, EVT is provided at few, mainly metropolitan, comprehensive stroke centres (CSC). There are significant challenges for Australia’s rural and remote populations in accessing EVT, but improved access can be facilitated by a ‘drip and ship’ approach. TACTICS (Trial of Advanced CT Imaging and Combined Education Support for Drip and Ship) aims to test whether a multicomponent, multidisciplinary impleme...
Source: BMJ Open - February 11, 2022 Category: General Medicine Authors: Ryan, A., Paul, C. L., Cox, M., Whalen, O., Bivard, A., Attia, J., Bladin, C., Davis, S. M., Campbell, B. C. V., Parsons, M., Grimley, R. S., Anderson, C., Donnan, G. A., Oldmeadow, C., Kuhle, S., Walker, F. R., Hood, R. J., Maltby, S., Keynes, A., Delcou Tags: Open access, Health services research Source Type: research