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Source: Molekuliarnaia Biologiia

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Total 145 results found since Jan 2013.

Multilocus analysis of the association of polymorphic variants of inflammation genes with ischemic stroke in Russians.
Abstract Carriage frequencies of alleles and genotypes of polymorphic loci of inflammation genes (49A>G CTLA4, 41G>A and 87C>T PDE4D, -590C>T IL4, -308A>G TNF, 252G>A LTA, 874A>T IFNG, -509С>Т, 869T>C and 915G>C TGFB1) were determined in a sample of 200 patients diagnosed with ischemic stroke and in the control group similar in gender and age (146 individuals), all ethnic Russians. The positive association of the allele PDE4D*87C (р = 0.028) and genotype TGFB1*-509Т/Т (р = 0.02) carriage with ischemic stroke was shown. The association of the disease with the carriage of the alle...
Source: Molekuliarnaia Biologiia - June 30, 2016 Category: Molecular Biology Authors: Titov BV, Matveeva NA, Martynov MY, Favorova OO Tags: Mol Biol (Mosk) Source Type: research

Ischemic stroke as a complex polygenic disease.
Abstract In the modern world acute cerebrovascular accidents (strokes) are one of the most important sociomedical problems due to their high share in the structure of morbidity, invalidization and mortality of the population. The main part of strokes is ischemic stroke (IS). IS is a complex (multifactorial) polygenic disease, i.e. develops as a result of interactions between risk factors and genetic components that determine a joint contribution of the sets of independently acting or interacting polymorphic genes. Currently, the search for a genetic predisposition to IS uses two main methods that are based on the ...
Source: Molekuliarnaia Biologiia - March 1, 2015 Category: Molecular Biology Authors: Titov BV, Matveeva NA, Martynov MY, Favorova OO Tags: Mol Biol (Mosk) Source Type: research

The Peptide Drug ACTH(4-7)PGP (Semax) Suppresses mRNA Transcripts Encoding Proinflammatory Mediators Induced by Reversible Ischemia of the Rat Brain
Mol Biol (Mosk). 2021 May-Jun;55(3):402-411. doi: 10.31857/S0026898421010043.ABSTRACTDue to its nootropic, neuroprotective, and immunomodulatory effects, the peptide Semax is utilized in the treatment of ischemic stroke. Our earlier RNA-Seq analysis of the transcriptome in an ischemic model of transient occlusion of the middle cerebral artery showed an increase in the mRNA levels of many proinflammatory genes, and the suppression of their induction by Semax. However, for many relevant genes, including Il1a, Il1b, Il6 and Tnfa, the levels of their expression were too low for detailed quantitative evaluation. Here we utilize...
Source: Molekuliarnaia Biologiia - June 7, 2021 Category: Molecular Biology Authors: L V Dergunova V G Dmitrieva I B Filippenkov V V Stavchansky A E Denisova V V Yuzhakov L E Sevan'kaeva L V Valieva O Y Sudarkina L V Gubsky N F Myasoedov S A Limborska Source Type: research