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Source: Biochemical Genetics
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Total 30 results found since Jan 2013.
The Association Between Thymidylate Synthase Gene Polymorphisms and the Risk of Ischemic Stroke in Chinese Han Population
In conclusion: This study has shown that TS rs699517 and rs2790 were significantly related to ischemic stroke patients.PMID:37378701 | DOI:10.1007/s10528-023-10431-8
Source: Biochemical Genetics - June 28, 2023 Category: Genetics & Stem Cells Authors: Fuhua Yu Lei Shi Qianru Wang Xiaohui Xing Zhongchen Li Lei Hou Zhengshan Zhou Zengguang Wang Yilei Xiao Source Type: research
Bioinformatics Approach to Identify the Influences of COVID-19 on Ischemic Stroke
In this study, bioinformatics approaches were utilized to explore potential pathogenic mechanisms and predict potential drugs that may be useful in the treatment of COVID-19 and IS. The GSE152418 and GSE122709 datasets were downloaded from the GEO website to obtain the common differentially expressed genes (DEGs) of the two datasets for further functional enrichment, pathway analysis, and drug candidate prediction. A total of 80 common DEGs were identified in COVID-19 and IS datasets for GO and KEGG analysis. Next, the protein-protein interaction (PPI) network was constructed and hub genes were identified. Further, transcr...
Source: Biochemical Genetics - May 15, 2023 Category: Genetics & Stem Cells Authors: Jiabao Zhu Xiangui Li Fanzhen Lv Weimin Zhou Source Type: research
Hsa_circ_0010729 is Involved in Oxygen-Glucose Deprivation/Reoxygenation-Induced Human Microvascular Endothelial Cell Deprivation by Targeting miR-665/ING5
In this study, we used oxygen-glucose deprivation/reoxygenation (OGD/R) to stimulate human brain microvascular endothelial cells (HBMECs) model to investigate the potential role of hsa_circ_0010729 in stroke in vitro. The expression levels of hsa_circ_0010729, miR-665, and ING5 in ischemic stroke were detected by quantitative real-time polymerase chain reaction (qRT-PCR). HBMECs proliferation was detected by CCK-8. Cell apoptosis was detected by flow cytometry. The levels of inflammatory cytokines were detected by enzyme-linked immunosorbent assay (ELISA). Western blot was used to detect the related protein expression. Dua...
Source: Biochemical Genetics - April 28, 2022 Category: Genetics & Stem Cells Authors: Xin Ouyang Guangbin Shi Shaomin Wang Li Chen Jinyan Xu Donglin Xie Source Type: research
