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Source: Autophagy

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Total 17 results found since Jan 2013.

Microglial phagocytosis dysfunction in stroke is driven by energy depletion and induction of autophagy
Autophagy. 2023 Jan 9. doi: 10.1080/15548627.2023.2165313. Online ahead of print.ABSTRACTMicroglial phagocytosis of apoptotic debris prevents buildup damage of neighbor neurons and inflammatory responses. Whereas microglia are very competent phagocytes under physiological conditions, we report their dysfunction in mouse and preclinical monkey models of stroke (macaques and marmosets) by transient occlusion of the medial cerebral artery (tMCAo). By analyzing recently published bulk and single cell RNA sequencing databases, we show that the phagocytosis dysfunction was not explained by transcriptional changes. In contrast, w...
Source: Autophagy - January 9, 2023 Category: Cytology Authors: Sol Beccari Virginia Sierra-Torre Jorge Valero Marta Pereira-Iglesias Mikel Garc ía-Zaballa Federico N Soria Laura De Las Heras-Garcia Alejandro Carretero-Guillen Estibaliz Capetillo-Zarate Maria Domercq Paloma R Huguet David Ramonet Ahmed Osman Wei Han Source Type: research

DBI/ACBP is a targetable autophagy checkpoint involved in aging and cardiovascular disease
In conclusion, it appears that extracellular DBI/ACBP can be targeted to combat age-associated cardiovascular disease.Abbreviations: BMI: body mass index; CDKN2A/p16: cyclin dependent kinase inhibitor 2A; CVD: cardiovascular disease; DBI/ACBP: diazepam binding inhibitor, acyl-CoA binding protein; ELISA: enzyme-linked immunosorbent assay; GABA: gamma-aminobutyric acid; GABR: gamma-aminobutyric acid type A receptor.PMID:36579946 | DOI:10.1080/15548627.2022.2160565
Source: Autophagy - December 29, 2022 Category: Cytology Authors: L éa Montégut Adrien Joseph Hui Chen Mahmoud Abdellatif Christoph Ruckenstuhl Isabelle Martins Frank Madeo Guido Kroemer Source Type: research

FOXP3+ macrophage represses acute ischemic stroke-induced neural inflammation
Autophagy. 2022 Sep 28:1-20. doi: 10.1080/15548627.2022.2116833. Online ahead of print.ABSTRACTProper termination of cell-death-induced neural inflammation is the premise of tissue repair in acute ischemic stroke (AIS). Macrophages scavenge cell corpses/debris and produce inflammatory mediators that orchestrate immune responses. Here, we report that FOXP3, the key immune-repressive transcription factor of Tregs, is conditionally expressed in macrophages in stroke lesion. FOXP3 ablation in macrophages results in detrimental stroke outcomes, emphasizing the beneficial role of FOXP3+ macrophages. FOXP3+ macrophages are distin...
Source: Autophagy - September 28, 2022 Category: Cytology Authors: Wei Cai Mengyan Hu Chunyi Li Ruizhen Wu Danli Lu Chichu Xie Wei Zhang Tiemei Li Shishi Shen Huipeng Huang Wei Qiu Quentin Liu Yan Lu Zhengqi Lu Source Type: research

Thrombolysis by PLAT/tPA increases serum free IGF1 leading to a decrease of deleterious autophagy following brain ischemia
Autophagy. 2021 Sep 14:1-21. doi: 10.1080/15548627.2021.1973339. Online ahead of print.ABSTRACTCerebral ischemia is a pathology involving a cascade of cellular mechanisms, leading to the deregulation of proteostasis, including macroautophagy/autophagy, and finally to neuronal death. If it is now accepted that cerebral ischemia induces autophagy, the effect of thrombolysis/energy recovery on proteostasis remains unknown. Here, we investigated the effect of thrombolysis by PLAT/tPA (plasminogen activator, tissue) on autophagy and neuronal death. In two in vitro models of hypoxia reperfusion and an in vivo model of thromboemb...
Source: Autophagy - September 14, 2021 Category: Cytology Authors: Audrey M Thiebaut Izaskun Buendia Vanessa Ginet Eloise Lemarchand Mehdi Boutagouga Boudjadja Yannick Hommet Laurent Lebouvier Charlotte Lechevallier Mike Maillasson Elodie Hedou Nicole D églon Franck Oury Marina Rubio Joan Montaner Julien Puyal Denis Viv Source Type: research

PARP14 inhibits microglial activation via LPAR5 to promote post-stroke functional recovery.
Abstract Stroke is a major public health problem leading to high rates of death and disability worldwide, but no effective pharmacological therapy is currently available except for the use of PLAT (plasminogen activator, tissue). Here we show that PARP14 (poly (ADP-ribose) polymerase family, member 14) level was significantly increased in the peri-infarct zone of photothrombotic stroke (PT) mice. Genetic knockdown and pharmacological inhibition of PARP14 aggravated functional impairment and increased infarct volume in PT mice, while overexpression of PARP14 displayed the opposite effects. Furthermore, PARP14 was a...
Source: Autophagy - December 15, 2020 Category: Cytology Authors: Tang Y, Liu J, Wang Y, Yang L, Han B, Zhang Y, Bai Y, Shen L, Li M, Jiang T, Ye Q, Yu X, Huang R, Zhang Z, Xu Y, Yao H Tags: Autophagy Source Type: research

Autophagy alleviates hypoxia-induced blood-brain barrier injury via regulation of CLDN5 (claudin 5).
Abstract Blood-brain barrier (BBB) disruption is a key event in triggering secondary damage to the central nervous system (CNS) under stroke, and is frequently associated with abnormal macroautophagy/autophagy in brain microvascular endothelial cells (BMECs). However, the underlying mechanism of autophagy in maintaining BBB integrity remains unclear. Here we report that in BMECs of patients suffering stroke, CLDN5 (claudin 5) abnormally aggregates in the cytosol accompanied by autophagy activation. In vivo zebrafish and in vitro cell studies reveal that BBB breakdown is partially caused by CAV1 (caveolin 1)-mediat...
Source: Autophagy - December 7, 2020 Category: Cytology Authors: Yang Z, Lin P, Chen B, Zhang X, Xiao W, Wu S, Huang C, Feng D, Zhang W, Zhang J Tags: Autophagy Source Type: research

Pharmacological restoration of autophagy reduces hypertension-related stroke occurrence.
Abstract The identification of the mechanisms predisposing to stroke may improve its preventive and therapeutic strategies in patients with essential hypertension. The role of macroautophagy/autophagy in the development of hypertension-related stroke needs to be clarified. We hypothesized that a defective autophagy may favor hypertension-related spontaneous stroke by promoting mitochondrial dysfunction. We studied autophagy in the stroke-prone spontaneously hypertensive (SHRSP) rat, which represents a clinically relevant model of stroke associated with high blood pressure. We assessed autophagy, mitophagy and NAD+...
Source: Autophagy - November 2, 2019 Category: Cytology Authors: Forte M, Bianchi F, Cotugno M, Marchitti S, De Falco E, Raffa S, Stanzione R, di Nonno F, Chimenti I, Palmerio S, Pagano F, Petrozza V, Micaloni A, Madonna M, Relucenti M, Torrisi MR, Frati G, Volpe M, Rubattu S, Sciarretta S Tags: Autophagy Source Type: research

Novel insight into circular RNA HECTD1 in astrocyte activation via autophagy by targeting MIR142-TIPARP: Implications for cerebral ischemic stroke.
Abstract Circular RNAs (circRNAs) are highly expressed in the central nervous system and are involved in the regulation of physiological and pathophysiological processes. However, the potential role of circRNAs in stroke remains largely unknown. Here, using a circRNA microarray, we showed that circular RNA Hectd1 (circHectd1) levels were significantly increased in ischemic brain tissues in transient middle cerebral artery occlusion (tMCAO) mouse stroke models and further validated this finding in plasma samples from acute ischemic stroke (AIS) patients. Knockdown of circHectd1 expression significantly decreased in...
Source: Autophagy - June 25, 2018 Category: Cytology Authors: Han B, Zhang Y, Zhang Y, Bai Y, Chen X, Huang R, Wu F, Leng S, Chao J, Zhang JH, Hu G, Yao H Tags: Autophagy Source Type: research