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Source: Antimicrobial Agents and Chemotherapy
Vaccination: Malaria Vaccine
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Total 11 results found since Jan 2013.
In vitro antimalarial activity of inhibitors of the human GTPase Rac1
Antimicrob Agents Chemother. 2021 Nov 1:AAC0149821. doi: 10.1128/AAC.01498-21. Online ahead of print.ABSTRACTMalaria accounts for millions of cases and thousands of deaths every year. In the absence of an effective vaccine, drugs are still the most important tool in the fight against the disease. Plasmodium parasites developed resistance for all the classes of known antimalarial drugs. Thus, the search for antimalarial drugs with novel mechanisms of action is compelling. The human GTPase Rac1 plays a role in parasite invasion of the host cell in many intracellular pathogens. Also in Plasmodium falciparum, it was suggested ...
Source: Antimicrobial Agents and Chemotherapy - November 1, 2021 Category: Microbiology Authors: Silvia Parapini Silvio Paone Emanuela Erba Loredana Cavicchini Manoochehr Pourshaban Francesco Celani Alessandro Contini Sarah D'Alessandro Anna Olivieri Source Type: research
Inhibitory compounds targeting < em > Plasmodium falciparum < /em > Gyrase B
Antimicrob Agents Chemother. 2021 Aug 2:AAC0026721. doi: 10.1128/AAC.00267-21. Online ahead of print.ABSTRACTMalaria persists as a major health problem due to the spread of drug resistance and the lack of effective vaccines. DNA gyrase is a well-validated and extremely effective therapeutic target in bacteria, and it is also known to be present in the apicoplast of malarial species including Plasmodium falciparum. This raises the possibility that it could be a useful target for novel antimalarials. To date, characterisation and screening of this gyrase has been hampered by difficulties in cloning and purification of the Gy...
Source: Antimicrobial Agents and Chemotherapy - August 2, 2021 Category: Microbiology Authors: Zuzanna Pakosz Ting-Yu Lin Elizabeth Michalczyk Soshichiro Nagano Jonathan Gardiner Heddle Source Type: research
