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Source: Annual Review of Pathology
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Total 2366 results found since Jan 2013.
Dynamic Multiplex Tissue Imaging in Inflammation Research
Annu Rev Pathol. 2023 Sep 18. doi: 10.1146/annurev-pathmechdis-070323-124158. Online ahead of print.ABSTRACTInflammation is a highly dynamic process with immune cells that continuously interact with each other and parenchymal components as they migrate through tissue. The dynamic cellular responses and interaction patterns are a function of the complex tissue environment that cannot be fully reconstructed ex vivo, making it necessary to assess cell dynamics and changing spatial patterning in vivo. These dynamics often play out deep within tissues, requiring the optical focus to be placed far below the surface of an opaque ...
Source: Annual Review of Pathology - September 18, 2023 Category: Pathology Authors: Stefan Uderhardt Georgiana Neag Ronald N Germain Source Type: research
Diffuse Pleural Mesothelioma: Advances in Molecular Pathogenesis, Diagnosis and Treatment
Annu Rev Pathol. 2023 Sep 18. doi: 10.1146/annurev-pathol-042420-092719. Online ahead of print.ABSTRACTDiffuse pleural mesothelioma (DPM) is a highly aggressive malignant neoplasm arising from the mesothelial cells lining the pleural surfaces. While DPM is a well-recognized disease linked to asbestos exposure, recent advances have expanded our understanding of molecular pathogenesis and transformed our clinical practice. This comprehensive review explores the current concepts and emerging trends in DPM, including risk factors, pathobiology, histologic subtyping, and therapeutic management, with an emphasis on a multidiscip...
Source: Annual Review of Pathology - September 18, 2023 Category: Pathology Authors: Christopher A Febres-Aldana Rachel Fanaroff Michael Offin Marjorie G Zauderer Jennifer L Sauter Soo-Ryum Yang Marc Ladanyi Source Type: research
Dynamic Multiplex Tissue Imaging in Inflammation Research
Annu Rev Pathol. 2023 Sep 18. doi: 10.1146/annurev-pathmechdis-070323-124158. Online ahead of print.ABSTRACTInflammation is a highly dynamic process with immune cells that continuously interact with each other and parenchymal components as they migrate through tissue. The dynamic cellular responses and interaction patterns are a function of the complex tissue environment that cannot be fully reconstructed ex vivo, making it necessary to assess cell dynamics and changing spatial patterning in vivo. These dynamics often play out deep within tissues, requiring the optical focus to be placed far below the surface of an opaque ...
Source: Annual Review of Pathology - September 18, 2023 Category: Pathology Authors: Stefan Uderhardt Georgiana Neag Ronald N Germain Source Type: research
Diffuse Pleural Mesothelioma: Advances in Molecular Pathogenesis, Diagnosis and Treatment
Annu Rev Pathol. 2023 Sep 18. doi: 10.1146/annurev-pathol-042420-092719. Online ahead of print.ABSTRACTDiffuse pleural mesothelioma (DPM) is a highly aggressive malignant neoplasm arising from the mesothelial cells lining the pleural surfaces. While DPM is a well-recognized disease linked to asbestos exposure, recent advances have expanded our understanding of molecular pathogenesis and transformed our clinical practice. This comprehensive review explores the current concepts and emerging trends in DPM, including risk factors, pathobiology, histologic subtyping, and therapeutic management, with an emphasis on a multidiscip...
Source: Annual Review of Pathology - September 18, 2023 Category: Pathology Authors: Christopher A Febres-Aldana Rachel Fanaroff Michael Offin Marjorie G Zauderer Jennifer L Sauter Soo-Ryum Yang Marc Ladanyi Source Type: research
Oropharyngeal Carcinoma with a Special Focus on HPV-Related Squamous Cell Carcinoma
Annu Rev Pathol. 2023 Jan 24;18:515-535. doi: 10.1146/annurev-pathmechdis-031521-041424.ABSTRACTHuman papillomavirus-positive oropharyngeal squamous cell carcinoma (HPV-OPSCC) has one of the most rapidly increasing incidences of any cancer in high-income countries. The most recent (8th) edition of the Union for International Cancer Control/American Joint Committee on Cancer staging system separates HPV-OPSCC from its HPV-negative counterpart to account for the improved prognosis seen in the former. Indeed, owing to its improved prognosis and greater prevalence in younger individuals, numerous ongoing trials are examining t...
Source: Annual Review of Pathology - January 24, 2023 Category: Pathology Authors: Robert L Ferris William Westra Source Type: research
Spatiotemporal Metabolic Liver Zonation and Consequences on Pathophysiology
Annu Rev Pathol. 2023 Jan 24;18:439-466. doi: 10.1146/annurev-pathmechdis-031521-024831.ABSTRACTHepatocytes are the main workers in the hepatic factory, managing metabolism of nutrients and xenobiotics, production and recycling of proteins, and glucose and lipid homeostasis. Division of labor between hepatocytes is critical to coordinate complex complementary or opposing multistep processes, similar to distributed tasks at an assembly line. This so-called metabolic zonation has both spatial and temporal components. Spatial distribution of metabolic function in hepatocytes of different lobular zones is necessary to perform ...
Source: Annual Review of Pathology - January 24, 2023 Category: Pathology Authors: Tomaz Martini Felix Naef Jan S Tchorz Source Type: research
My Journey
Annu Rev Pathol. 2023 Jan 24;18:1-18. doi: 10.1146/annurev-pathmechdis-031621-025854.ABSTRACTThis is the life story of Dr. Lucy B. Rorke-Adams, who was raised in the rural Midwest of the United States by Armenian immigrant parents during the Depression. The youngest in a family of five girls, she was lovingly nurtured by her parents and sisters. She was encouraged to become educated in order to lead a worthwhile life and contribute to society. She chose medicine, specifically the specialty of pediatric neuropathology, and over her long career succeeded in advancing the field. In particular, she made major contributions to ...
Source: Annual Review of Pathology - January 24, 2023 Category: Pathology Authors: Lucy Balian Rorke-Adams Source Type: research
Oropharyngeal Carcinoma with a Special Focus on HPV-Related Squamous Cell Carcinoma
Annu Rev Pathol. 2023 Jan 24;18:515-535. doi: 10.1146/annurev-pathmechdis-031521-041424.ABSTRACTHuman papillomavirus-positive oropharyngeal squamous cell carcinoma (HPV-OPSCC) has one of the most rapidly increasing incidences of any cancer in high-income countries. The most recent (8th) edition of the Union for International Cancer Control/American Joint Committee on Cancer staging system separates HPV-OPSCC from its HPV-negative counterpart to account for the improved prognosis seen in the former. Indeed, owing to its improved prognosis and greater prevalence in younger individuals, numerous ongoing trials are examining t...
Source: Annual Review of Pathology - January 24, 2023 Category: Pathology Authors: Robert L Ferris William Westra Source Type: research
Spatiotemporal Metabolic Liver Zonation and Consequences on Pathophysiology
Annu Rev Pathol. 2023 Jan 24;18:439-466. doi: 10.1146/annurev-pathmechdis-031521-024831.ABSTRACTHepatocytes are the main workers in the hepatic factory, managing metabolism of nutrients and xenobiotics, production and recycling of proteins, and glucose and lipid homeostasis. Division of labor between hepatocytes is critical to coordinate complex complementary or opposing multistep processes, similar to distributed tasks at an assembly line. This so-called metabolic zonation has both spatial and temporal components. Spatial distribution of metabolic function in hepatocytes of different lobular zones is necessary to perform ...
Source: Annual Review of Pathology - January 24, 2023 Category: Pathology Authors: Tomaz Martini Felix Naef Jan S Tchorz Source Type: research
Oropharyngeal Carcinoma with a Special Focus on HPV-Related Squamous Cell Carcinoma
Annu Rev Pathol. 2023 Jan 24;18:515-535. doi: 10.1146/annurev-pathmechdis-031521-041424.ABSTRACTHuman papillomavirus-positive oropharyngeal squamous cell carcinoma (HPV-OPSCC) has one of the most rapidly increasing incidences of any cancer in high-income countries. The most recent (8th) edition of the Union for International Cancer Control/American Joint Committee on Cancer staging system separates HPV-OPSCC from its HPV-negative counterpart to account for the improved prognosis seen in the former. Indeed, owing to its improved prognosis and greater prevalence in younger individuals, numerous ongoing trials are examining t...
Source: Annual Review of Pathology - January 24, 2023 Category: Pathology Authors: Robert L Ferris William Westra Source Type: research
Spatiotemporal Metabolic Liver Zonation and Consequences on Pathophysiology
Annu Rev Pathol. 2023 Jan 24;18:439-466. doi: 10.1146/annurev-pathmechdis-031521-024831.ABSTRACTHepatocytes are the main workers in the hepatic factory, managing metabolism of nutrients and xenobiotics, production and recycling of proteins, and glucose and lipid homeostasis. Division of labor between hepatocytes is critical to coordinate complex complementary or opposing multistep processes, similar to distributed tasks at an assembly line. This so-called metabolic zonation has both spatial and temporal components. Spatial distribution of metabolic function in hepatocytes of different lobular zones is necessary to perform ...
Source: Annual Review of Pathology - January 24, 2023 Category: Pathology Authors: Tomaz Martini Felix Naef Jan S Tchorz Source Type: research
My Journey
Annu Rev Pathol. 2023 Jan 24;18:1-18. doi: 10.1146/annurev-pathmechdis-031621-025854.ABSTRACTThis is the life story of Dr. Lucy B. Rorke-Adams, who was raised in the rural Midwest of the United States by Armenian immigrant parents during the Depression. The youngest in a family of five girls, she was lovingly nurtured by her parents and sisters. She was encouraged to become educated in order to lead a worthwhile life and contribute to society. She chose medicine, specifically the specialty of pediatric neuropathology, and over her long career succeeded in advancing the field. In particular, she made major contributions to ...
Source: Annual Review of Pathology - January 24, 2023 Category: Pathology Authors: Lucy Balian Rorke-Adams Source Type: research
