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Less Sodium, More Potassium, or Both: Population-wide Strategies to Prevent Hypertension
Am J Physiol Renal Physiol. 2023 Jun 1. doi: 10.1152/ajprenal.00007.2023. Online ahead of print.ABSTRACTHypertension is among the most prevalent medical conditions globally and a major contributor to chronic kidney disease, cardiovascular disease, and death. Prevention through non-pharmacologic, population-level interventions is critically needed to halt this worldwide epidemic. However, there are ongoing debates as to where public policy efforts should focus. Recently the Salt Substitute and Stroke Study demonstrated the efficacy of substituting table salt with potassium salt to reduce the risk of stroke, major cardiovasc...
Source: American Journal of Physiology. Renal Physiology - June 1, 2023 Category: Physiology Authors: Voravech Nissaisorakarn George Ormseth William Earle Martha Catalina Morales-Alvarez Swapnil Hiremath Stephen P Juraschek Source Type: research

The increase of core temperature affected the progression of kidney injury by repeated heat stress exposure.
CONCLUSIONS: These studies suggest that kidney injury in heat stress is markedly worsened by increasing core temperature. The studies are consistent with the hypothesis that clinical and subclinical heat stroke may play a role in Mesoamerican Nephropathy. PMID: 31390229 [PubMed - as supplied by publisher]
Source: American Journal of Physiology. Renal Physiology - August 6, 2019 Category: Physiology Authors: Sato Y, Roncal-Jimenez CA, Andres-Hernando A, Jensen T, Tolan DR, Sanchez-Lozada LG, Newman LS, Butler-Dawson J, Sorensen C, Glaser J, Miyazaki M, Diaz HF, Ishimoto T, Kosugi T, Maruyama S, Garcia GE, Lanaspa MA, Johnson RJ Tags: Am J Physiol Renal Physiol Source Type: research

Prevention of contrast-induced nephropathy by limb ischemic preconditioning: Underlying mechanisms and clinical effects.
Abstract Contrast-induced nephropathy (CIN) is an important complication following diagnostic radiographic imaging and interventional therapy. It results from administration of intravascular iodinated contrast media (CM) and is currently the third most common cause of hospital-acquired acute kidney injury. CIN is associated with increased morbidity, prolonged hospitalization and higher mortality. Although the importance of CIN is widely appreciated, and its occurrence can be mitigated by the use of pre- and post-hydration protocols and low osmolar instead of high osmolar iodine-containing CM, specific prophylactic...
Source: American Journal of Physiology. Renal Physiology - May 31, 2017 Category: Physiology Authors: Dugbartey G, Redington AN Tags: Am J Physiol Renal Physiol Source Type: research

Inhibition of HDAC6 protects against rhabdomyolysis-induced acute kidney injury.
In this study, we examined the therapeutic effect of tubastatin A (TA), a highly selective inhibitor of HDAC6, on AKI in a murine model of glycerol (GL) injection-induced rhabdomyolysis. Following GL injection, the mice developed severe acute tubular injury as indicated by renal dysfunction, expression of neutrophil gelatinase-associated lipocalin (NGAL), an injury marker of renal tubules and increase of TUNEL positive tubular cells. These changes were companied by increased HDAC6 expression in the cytoplasm of renal tubular cells. Administration of TA significantly reduced serum creatinine and blood urea nitrogen levels a...
Source: American Journal of Physiology. Renal Physiology - January 3, 2017 Category: Physiology Authors: Yingfeng S, Liuqing X, Jinhua T, Lu F, Shuchen M, Xiaoyan M, Jing N, Xiaoling P, Andong Q, Shougang Z, Na L Tags: Am J Physiol Renal Physiol Source Type: research

Path of Translational Discovery of "Urological Complications of Obesity and Diabetes (UCOD)".
Abstract Diabetes Mellitus (DM) is a prevalent chronic disease. Type 1 diabetes mellitus (T1DM) is a metabolic disorder that is characterized by hyperglycemia in the context of absolute lack of insulin; whereas type 2 diabetes mellitus (T2DM) is due to insulin resistance-related relative insulin deficiency. Obesity is an established risk factor for T2DM. In comparison with T1DM, T2DM is more complex. The natural history of T2DM in most patients typically involves a course of obesity to impaired glucose tolerance, to insulin resistance and hyperglycemia. Diabetes causes some serious microvascular and macrovascular ...
Source: American Journal of Physiology. Renal Physiology - January 3, 2017 Category: Physiology Authors: Daneshgari F, Liu G, Hanna-Mitchell AT Tags: Am J Physiol Renal Physiol Source Type: research

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