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Source: Clinical Cardiology

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Total 111 results found since Jan 2013.

Practical Considerations for Using Novel Oral Anticoagulants in Patients With Atrial Fibrillation
Abstract Novel oral anticoagulants, including dabigatran, rivaroxaban, and apixaban, represent new options for preventing stroke in patients with atrial fibrillation, as shown by the results from large, randomized phase III trials. Because of their greater specificity, rapid onset of action, and predictable pharmacokinetics, the novel oral anticoagulants (dabigatran, rivaroxaban, and apixaban) address several limitations of warfarin or other vitamin K antagonists in day‐to‐day clinical practice. However, a range of practical questions relating to the novel oral anticoagulants has emerged, including topics such as patie...
Source: Clinical Cardiology - November 19, 2013 Category: Cardiology Authors: Irene Savelieva, A. John Camm Tags: Review Source Type: research

Management of Postoperative Atrial Fibrillation and Subsequent Outcomes in Contemporary Patients Undergoing Cardiac Surgery: Insights From the Society of Thoracic Surgeons CAPS‐Care Atrial Fibrillation Registry
ConclusionsPostoperative AF is common following CABG, and such patients continue to have higher rates of postoperative complications. Postoperative AF is significantly associated with increased length of stay following surgery.
Source: Clinical Cardiology - December 1, 2013 Category: Cardiology Authors: Benjamin A. Steinberg, Yue Zhao, Xia He, Adrian F. Hernandez, David A. Fullerton, Kevin L. Thomas, Roger Mills, Winslow Klaskala, Eric D. Peterson, Jonathan P. Piccini Tags: Quality and Outcomes Source Type: research

One‐Year Outcome of Patients With Atrial Fibrillation Undergoing Coronary Artery Stenting: An Analysis of the AFCAS Registry
ConclusionsIn this large, real‐world population of AF patients undergoing PCI‐S, TT was the antithrombotic regimen most frequently prescribed. Although several limitations need to be acknowledged, in our study the 1‐year efficacy and safety of TT, dual antiplatelet therapy, and VKA plus clopidogrel was comparable.
Source: Clinical Cardiology - January 30, 2014 Category: Cardiology Authors: Andrea Rubboli, Axel Schlitt, Tuomas Kiviniemi, Fausto Biancari, Pasi P. Karjalainen, Josè Valencia, Mika Laine, Paulus Kirchhof, Matti Niemelä, Saila Vikman, Gregory Y. H. Lip, K. E. Juhani Airaksinen, Tags: Clinical Investigations Source Type: research

Regional Variation Across the United States in Management and Outcomes of ST‐Elevation Myocardial Infarction: Analysis of the 2003 to 2010 Nationwide Inpatient Sample Database
ConclusionsDespite higher reperfusion and revascularization rates, STEMI patients in the Midwest, West, and South have paradoxically higher risk‐adjusted in‐hospital mortality as compared with patients in the Northeast.
Source: Clinical Cardiology - January 29, 2014 Category: Cardiology Authors: Dhaval Kolte, Sahil Khera, Wilbert S. Aronow, Marjan Mujib, Chandrasekar Palaniswamy, Ali Ahmed, William H. Frishman, Gregg C. Fonarow Tags: Quality and Outcomes Source Type: research

Impact of Obstructive Sleep Apnea on Cardiovascular Outcomes in Patients Treated With Percutaneous Coronary Intervention: Rationale and Design of the Sleep and Stent Study
ABSTRACT Elucidating the effects of obstructive sleep apnea (OSA) on cardiovascular outcomes is crucial in risk assessments and therapeutic recommendations for affected individuals. The Sleep and Stent Study is a multicenter observational study investigating the relationships between OSA and cardiovascular outcomes in patients treated with percutaneous coronary intervention (PCI). Eight centers in 5 countries (Singapore, China and Hong Kong, India, Myanmar, and Brazil) are participating in the study, and the recruitment target is 1600 patients. Adult patients age 18 to 80 years who have undergone successful PCI are eligibl...
Source: Clinical Cardiology - February 22, 2014 Category: Cardiology Authors: Germaine Loo, Chieh‐Yang Koo, Junjie Zhang, Ruogu Li, Rithi Sethi, Thun‐How Ong, Bee‐Choo Tai, Chi‐Hang Lee Tags: Trial Designs Source Type: research

Comparison of Clinical Trial Outcome Patterns in Patients Following Acute Coronary Syndromes and in Patients With Chronic Stable Atherosclerosis
ConclusionsPatients with ACS enrolled while in the hospital appear to have different risk profiles for ischemic and bleeding outcomes compared with outpatients enrolled with CSA, including those patients with ACS after the acute phase.
Source: Clinical Cardiology - February 1, 2014 Category: Cardiology Authors: Kenneth W. Mahaffey, Daniel M. Wojdyla, Karen S. Pieper, Pierluigi Tricoci, John H. Alexander, A. Michael Lincoff, Danielle M. Brennan, Deepak L. Bhatt, Lars Wallentin, Robert A. Harrington Tags: Clinical Investigation Source Type: research

The Role of Vitamin Supplementation in the Prevention of Cardiovascular Disease Events
ABSTRACT The production, sale, and consumption of multiple vitamins is a multibillion‐dollar industry. Most Americans take some form of supplement ostensibly for prevention of cardiovascular disease. It has been claimed that vitamin A retards atherogenesis. Vitamin C is an antioxidant and is thought to possibly decrease free radical‐induced endothelial injury, which can lead to atherosclerotic plaque formation. Vitamin E has been extensively studied for its possible effects on platelet function as well as inhibition of foam‐cell formation. Low levels of vitamin D have been thought to negatively impact myocardial stru...
Source: Clinical Cardiology - April 1, 2014 Category: Cardiology Authors: Chirag K. Desai, Jennifer Huang, Adil Lokhandwala, Aaron Fernandez, Irbaz Bin Riaz, Joseph S. Alpert Tags: Review Source Type: research

One‐Year Outcomes Associated With Using Observation Services in Triaging Patients With Nonspecific Chest Pain
ConclusionsPatients who had observation services had similar outcomes and 1‐year costs compared to patients admitted to inpatient wards.
Source: Clinical Cardiology - August 11, 2014 Category: Cardiology Authors: Ibrahim M. Abbass, Salim S. Virani, J. Michael Swint, Wenyaw Chan, Luisa Franzini Tags: Quality and Outcomes Source Type: research

Noncardiac Surgery in Patients With Aortic Stenosis: A Contemporary Study on Outcomes in a Matched Sample From the Danish Health Care System
ConclusionsAS is associated with high perioperative rates of MACE and mortality, but perhaps prognosis is, in practice, not much worse for patients with AS than for matched controls. Symptomatic patients and patients undergoing emergency surgery are at considerable risks of a MACE and mortality.
Source: Clinical Cardiology - September 15, 2014 Category: Cardiology Authors: Charlotte Andersson, Mads Emil Jørgensen, Andreas Martinsson, Peter Wæde Hansen, J. Gustav Smith, Per Føge Jensen, Gunnar H. Gislason, Lars Køber, Christian Torp‐Pedersen Tags: Clinical Investigation Source Type: research

Statins in the Elderly: A Patient‐Focused Approach
ABSTRACT Individuals age >65 years represent the fastest‐growing subpopulation in the United States. Although these individuals with the highest cardiovascular risk profile would be anticipated to be the most aggressively treated, paradoxically, treatment and baseline risk are inversely related. Presumably, the elderly population would benefit from high‐intensity statin therapy; however, as per the 2013 American College of Cardiology/American Heart Association guidelines, given the scarcity of evidence in patients age >75, there are only sufficient data from randomized controlled trials to support use of modera...
Source: Clinical Cardiology - September 1, 2014 Category: Cardiology Authors: Kobina A. Wilmot, Abdullah Khan, Sandeep Krishnan, Danny J. Eapen, Laurence Sperling Tags: Reviews Source Type: research

Characterizing Major Bleeding in Patients With Nonvalvular Atrial Fibrillation: A Pharmacovigilance Study of 27 467 Patients Taking Rivaroxaban
ConclusionsIn this large observational study, the MB rate was generally consistent with the registration trial results, and fatal bleeds were rare.
Source: Clinical Cardiology - December 1, 2014 Category: Cardiology Authors: Sally Tamayo, W. Frank Peacock, Manesh Patel, Nicholas Sicignano, Kathleen P. Hopf, Larry E. Fields, Troy Sarich, Shujian Wu, Daniel Yannicelli, Zhong Yuan Tags: Quality and Outcomes Source Type: research

Carotid Intima‐Media Thickness Measurement Promises to Improve Cardiovascular Risk Evaluation in Head and Neck Cancer Patients
ConclusionsCarotid IMT identified a much greater percentage of radiation‐treated HNC patients at high CV risk compared with standard CV‐risk calculators. By more accurately identifying the patients at high risk, this may lead to more effective prevention, and therefore a reduction in CV events.
Source: Clinical Cardiology - May 11, 2015 Category: Cardiology Authors: Douglas Jacoby, Jihane Hajj, Ali Javaheri, Emil deGoma, Alexander Lin, Peter Ahn, Harry Quon Tags: Clinical Investigations Source Type: research

Non–Vitamin K Antagonist Oral Anticoagulant Use in Patients With Atrial Fibrillation and Associated Intracranial Hemorrhage: A Focused Review
ABSTRACT Atrial fibrillation (AF) is the most common cardiac arrhythmia and predisposes patients to an increased risk of embolic stroke. After nearly 60 years, warfarin is no longer the only effective therapeutic option for patients with AF. Large randomized trials have consistently shown that non–vitamin K oral anticoagulants (NOACs) including dabigatran, rivaroxaban, apixaban, and edoxaban significantly reduce from the risk of intracranial hemorrhage (ICH) compared with warfarin. We provide a focused review regarding the NOACs and ICH in AF patients by summarizing findings of these large clinical trials, mechanisms of ...
Source: Clinical Cardiology - July 14, 2015 Category: Cardiology Authors: Boris Arbit, Jonathan C. Hsu Tags: Review Source Type: research

The HAS‐BLED Score for Predicting Major Bleeding Risk in Anticoagulated Patients With Atrial Fibrillation: A Systematic Review and Meta‐analysis
ABSTRACT Our objective was to compare the diagnostic accuracy between the HAS‐BLED score and any of HEMORR2HAGES, ATRIA, CHADS2, or CHA2DS2‐VASc scores in anticoagulated patients with atrial fibrillation. We systematically searched the Cochrane Library, MEDLINE, PubMed, and Embase databases for relevant studies. Data were extracted and analyzed according to predefined clinical endpoints. Eleven studies were identified. Discrimination analysis demonstrates that HAS‐BLED has no significant C‐statistic differences for bleeding risk prediction compared with ATRIA or HEMORR2HAGES, but it has significant differences comp...
Source: Clinical Cardiology - September 29, 2015 Category: Cardiology Authors: Wengen Zhu, Wenfeng He, Linjuan Guo, Xixing Wang, Kui Hong Tags: Review Source Type: research

Initial Experience With Novel Oral Anticoagulants During the First 45 Days After Left Atrial Appendage Closure With the Watchman Device
ConclusionsOur pilot study suggests that NOAC therapy within the first 45 days after interventional LAA closure is safe and effective.
Source: Clinical Cardiology - September 1, 2015 Category: Cardiology Authors: Leif I. Bösche, Faegheh Afshari, Dominik Schöne, Aydan Ewers, Andreas Mügge, Michael Gotzmann Tags: Clinical Investigations Source Type: research