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Source: Clinical Cardiology

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Total 111 results found since Jan 2013.

Real ‐world incidence of efficacy and safety outcomes in patients on direct oral anticoagulants with left ventricular systolic dysfunction at a tertiary referral center
ConclusionsOur findings are largely compatible with the results of LVSD or HF subgroups in RE‐LY, ROCKET‐AF, and ARISTOTLE trials and add to increasing confidence that DOACs can be safely used for stroke and systemic embolism prevention in patients with LVSD.
Source: Clinical Cardiology - November 1, 2017 Category: Cardiology Authors: Andrew S. Tseng, J. William Schleifer, Win ‐Kuang Shen, Robert McBane, Sunil Mankad, Heidi Esser, Darko Vucicevic, Fadi E. Shamoun Tags: CLINICAL INVESTIGATIONS Source Type: research

Incidence of thromboembolic and bleeding events in patients with newly diagnosed nonvalvular atrial fibrillation: An Asian multicenter retrospective cohort study in Singapore
ConclusionsSAPT and DAPT are less effective than warfarin in NVAF patients. DOACs may be considered in view of lower risk of overall bleed.
Source: Clinical Cardiology - November 1, 2017 Category: Cardiology Authors: Xue Ting Wee, Lih Maan Ho, Han Kiat Ho, Joyce Yu ‐Chia Lee, Chun Wei Yap, Henry William, Linus Chong En Chan, Hooi Ching Tay, Cynthia Eei Mei Goh, Doreen Su‐Yin Tan Tags: CLINICAL INVESTIGATIONS Source Type: research

Growth differentiation factor 15 is associated with left atrial/left atrial appendage thrombus in patients with nonvalvular atrial fibrillation
ConclusionsElevated GDF‐15 indicated a significantly increased risk for LA/LAA thrombus in NVAF patients. Thus, GDF‐15 might be a potentially useful adjunct in discriminating LA/LAA thrombus in NVAF patients.
Source: Clinical Cardiology - January 24, 2018 Category: Cardiology Authors: Xiao Feng Hu, Rui Zhan, Shanhu Xu, Junjun Wang, Jiong Wu, Xiaoli Liu, Yaguo Li, Linhui Chen Tags: CLINICAL INVESTIGATIONS Source Type: research

Detection and management of atrial fibrillation after cryptogenic stroke or embolic stroke of undetermined source
Clinical Cardiology, EarlyView.
Source: Clinical Cardiology - March 22, 2018 Category: Cardiology Source Type: research

Predictors of all ‐cause mortality and ischemic events within and beyond 1 year after an acute coronary syndrome: results from the EPICOR registry
ConclusionWe observed continuous MACCE risk during 2 years of follow ‐up after discharge for ACS, with greater mortality within the first year. Specific predictors at discharge for events after 1 year could not be identified.
Source: Clinical Cardiology - November 15, 2018 Category: Cardiology Authors: Xavier Rossello, H éctor Bueno, Stuart J Pocock, Frans Van de Werf, Nicolas Danchin, Lieven Annemans, Jesús Medina, Uwe Zeymer Tags: CLINICAL INVESTIGATIONS Source Type: research

Risk Factors, Therapeutic Approaches, and In‐Hospital Outcomes in Mexicans With ST‐Elevation Acute Myocardial Infarction: The RENASICA II Multicenter Registry
ConclusionsLargely modifiable risk factors and preventable short‐term complications are responsible for most STEMI cases and outcomes in this Mexican population.
Source: Clinical Cardiology - March 14, 2013 Category: Cardiology Authors: Úrsulo Juárez‐Herrera, Carlos Jerjes‐Sánchez, Tags: Quality and Outcomes Source Type: research

Mortality Implications of Angina and Blood Pressure in Hypertensive Patients With Coronary Artery Disease: New Data From Extended Follow‐up of the International Verapamil/Trandolapril Study (INVEST)
ConclusionsIn hypertensive CAD patients, persistent angina was associated with lower mortality. The observed effect was small compared with other cardiovascular risk factors, such as BP, which were associated with increased mortality.
Source: Clinical Cardiology - May 29, 2013 Category: Cardiology Authors: David E. Winchester, Rhonda M. Cooper‐DeHoff, Yan Gong, Eileen M. Handberg, Carl J. Pepine, Tags: Quality and Outcome Source Type: research

Landmark Lipid‐Lowering Trials in the Primary Prevention of Cardiovascular Disease
Abstract Although atherosclerotic cardiovascular disease (CVD) is the most common cause of morbidity and mortality in the world, the long disease latency affords ample opportunity for preventive care. Indeed, lifelong exposure to atherogenic apoliprotein B‐containing lipoproteins has consistently been shown to increase the cumulative risk of suffering a CVD event, including myocardial infarction, stroke, and symptomatic peripheral arterial disease. Over the past 25 years, lipid‐lowering therapies have been developed that are proven to not only lower cholesterol, but also to decrease adverse CVD events and CVD mortali...
Source: Clinical Cardiology - May 1, 2013 Category: Cardiology Authors: Jonathan Chrispin, Seth S. Martin, Rani K. Hasan, Parag H. Joshi, C. Michael Minder, John W. McEvoy, Payal Kohli, Amber E. Johnson, Libin Wang, Michael J. Blaha, Roger S. Blumenthal Tags: Review Source Type: research

Rationale and Methodology of the Impact of Continuous Positive Airway Pressure on Patients With ACS and Nonsleepy OSA: The ISAACC Trial
ConclusionsThe ISAACC trial will contribute to evaluating the effect of CPAP treatment on cardiovascular events in patients with ACS and OSA.
Source: Clinical Cardiology - July 10, 2013 Category: Cardiology Authors: Cristina Esquinas, Manuel Sánchez‐de‐la Torre, Albina Aldomá, Marina Florés, Montserrat Martínez, Antonia Barceló, Ferran Barbé, Tags: Trial Design Source Type: research

Triple Oral Antithrombotic Therapy in Atrial Fibrillation and Coronary Artery Stenting
Patients with atrial fibrillation affected by an acute coronary syndrome have indications for oral anticoagulation and dual antiplatelet therapy with aspirin and a P2Y12 adenosine diphosphate receptor inhibitor after coronary artery stenting. The concurrent use of all 3 agents, termed triple oral antithrombotic therapy, significantly increases the risk of bleeding. To date, there is a lack of evidence on the proper combination and duration of anticoagulant and antiplatelet agents in patients with indications for both therapies. As such, care has been guided by expert opinion, and there is wide variation in clinician practi...
Source: Clinical Cardiology - July 1, 2013 Category: Cardiology Authors: Grant W. Reed, Christopher P. Cannon Tags: Review Source Type: research

Oral Anticoagulants to Reduce the Risk of Stroke in Atrial Fibrillation: How Should a Clinician Choose?
This article discusses issues that may help clinicians choose among these newer agents and individualize treatment appropriately.
Source: Clinical Cardiology - July 1, 2013 Category: Cardiology Authors: Ilyas Mohammed, Wajihuddin Syed, Peter R. Kowey Tags: Reviews Source Type: research

Bosentan Treatment Is Associated With Improvement of Right Ventricular Function and Remodeling in Chronic Thromboembolic Pulmonary Hypertension
ConclusionsIn CTEPH, compared with control, treatment with bosentan for 16 weeks was associated with a significant improvement in cMRI parameters of RV function and remodelling.
Source: Clinical Cardiology - August 27, 2013 Category: Cardiology Authors: Sulaiman Surie, Herre J. Reesink, J. Tim Marcus, Mart N. van der Plas, Jaap J. Kloek, Anton Vonk‐Noordegraaf, Paul Bresser Tags: Clinical Investigation Source Type: research

Postdischarge International Normalized Ratio Testing and Long‐term Clinical Outcomes of Patients With Heart Failure Receiving Warfarin: Findings From the ADHERE Registry Linked to Medicare Claims
ConclusionsPostdischarge outpatient INR testing in patients with heart failure complicated by atrial fibrillation or valvular heart disease was high. INR testing was associated with improved survival and fewer myocardial infarctions at 1 year but was not independently associated with other adverse clinical events.
Source: Clinical Cardiology - October 1, 2013 Category: Cardiology Authors: Laura G. Qualls, Melissa A. Greiner, Zubin J. Eapen, Gregg C. Fonarow, Roger M. Mills, Winslow Klaskala, Adrian F. Hernandez, Lesley H. Curtis Tags: Clinical Investigation Source Type: research

Predictors of Long‐term Adherence to Evidence‐based Cardiovascular Disease Medications in Outpatients With Stable Atherothrombotic Disease: Findings From the REACH Registry
ConclusionsUsing a large international registry of outpatients with atherothrombotic disease, we found that age, region, race/ethnicity, and incident cardiovascular events were predictive of long‐term guideline adherence for secondary prevention, suggesting that certain patient groups may benefit from targeted interventions to improve adherence.
Source: Clinical Cardiology - October 1, 2013 Category: Cardiology Authors: Fátima Rodriguez, Christopher P. Cannon, Ph. Gabriel Steg, Dharam J. Kumbhani, Shinya Goto, Sidney C. Smith, Kim A. Eagle, E. Magnus Ohman, Amarachi A. Umez‐Eronini, Elaine Hoffman, Deepak L. Bhatt, Tags: Quality and Outcome Source Type: research

Mediators of Atherosclerosis in South Asians Living in America (MASALA) Study: Objectives, Methods, and Cohort Description
ConclusionsThe MASALA study will provide novel data on the prevalence and associations of cardiovascular risk factors and subclinical atherosclerosis in South Asians living in the United States.
Source: Clinical Cardiology - November 5, 2013 Category: Cardiology Authors: Alka M. Kanaya, Namratha Kandula, David Herrington, Matthew J. Budoff, Stephen Hulley, Eric Vittinghoff, Kiang Liu Tags: Trial Design Source Type: research