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Specialty: Neurology
Source: Neurobiology of Disease
Therapy: Dialysis
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Total 1 results found since Jan 2013.
Astrocytic Ca(2+) waves mediate activation of extrasynaptic NMDA receptors in hippocampal neurons to aggravate brain damage during ischemia.
Abstract
Excitotoxicity plays a central role in the neuronal damage during ischemic stroke. Although growing evidence suggests that activation of extrasynaptic NMDA receptors initiates the neuronal death, no direct evidence demonstrated their activation during ischemia. Using rat hippocampal slices, we detected oxygen-glucose deprivation (OGD) induced slow inward currents (SICs) mediated by extrasynaptic NMDA receptors in CA1 pyramidal neurons. Moreover, Ca(2+) chelator BAPTA dialysis into astrocytic network decreased the frequency of OGD induced SICs, indicating the activation of extrasynaptic NMDA receptors depe...
Source: Neurobiology of Disease - May 20, 2013 Category: Neurology Authors: Dong QP, He JQ, Chai Z Tags: Neurobiol Dis Source Type: research
