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Specialty: Sleep Medicine
Source: Sleep

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Total 25 results found since Jan 2013.

Obstructive Sleep Apnea is Related to Impaired Cognitive and Functional Status after Stroke
Conclusions:Obstructive sleep apnea (OSA) is associated with a lower cognitive and functional status in patients admitted for stroke rehabilitation. This underlines the importance of OSA as a probable prognostic factor, and calls for well-designed randomized controlled trials to study its treatability.Citation:Aaronson JA, van Bennekom CA, Hofman WF, van Bezeij T, van den Aardweg JG, Groet E, Kylstra WA, Schmand B. Obstructive sleep apnea is related to impaired cognitive and functional status after stroke. SLEEP 2015;38(9):1431–1437.
Source: Sleep - September 1, 2015 Category: Sleep Medicine Source Type: research

Sleep Disordered Breathing and Risk of Stroke in Older Community-Dwelling Men
Conclusions:Older men with severe nocturnal hypoxemia are at significantly increased risk of incident stroke. Measures of overnight oxygen saturation may better identify older men at risk for stroke than measures of apnea frequency.Citation:Stone KL, Blackwell TL, Ancoli-Israel S, Barrett-Connor E, Bauer DC, Cauley JA, Ensrud KE, Hoffman AR, Mehra R, Stefanick ML, Varosy PD, Yaffe K, Redline S; Osteoporotic Fractures in Men Study Research Group. Sleep disordered breathing and risk of stroke in older community-dwelling men. SLEEP 2016;39(3):531–540.
Source: Sleep - March 1, 2016 Category: Sleep Medicine Source Type: research

Associations between Cardioembolic Stroke and Obstructive Sleep Apnea
Conclusions:There appears to be a strong association between obstructive sleep apnea (OSA) and cardioembolic (CE) stroke. In patients with OSA presenting with cryptogenic stroke, high clinical suspicion for CE is warranted. This may lead to consideration of diagnostic studies to identify CE risk factors such as paroxysmal atrial fibrillation (AF). CE strokes are more common in patients with OSA even after adjusting for AF. This finding may reflect a high rate of occult paroxysmal AF in this population; alternatively, OSA may lead to CE strokes through mechanisms independent of AF.Citation:Lipford MC, Flemming KD, Calvin AD...
Source: Sleep - October 31, 2015 Category: Sleep Medicine Source Type: research

Identification of Sleep-Modulated Pathways Involved in Neuroprotection from Stroke
Conclusion: Our data indicate that sleep deprivation before stroke reprogrammed the signaling response to injury. The inhibition of cell cycle regulation and inflammation are neuroprotective mechanisms reported also for other forms of preconditioning treatment, whereas the implication of the neuroendocrine function is novel and has never been described before. These results therefore provide new insights into neuroprotective mechanisms involved in ischemic tolerance mechanisms. Citation: Pace M, Baracchi F, Gao B, Bassetti C. Identification of sleep-modulated pathways involved in neuroprotection from stroke. SLEEP 2015;3...
Source: Sleep - October 31, 2015 Category: Sleep Medicine Source Type: research

Silent Cerebral Small Vessel Disease in Restless Legs Syndrome
Conclusion:RLS duration should be taken into account when analyzing the association between RLS and cerebrovascular disease; our data support the hypothesis that a long-lasting RLS and its accompanying periodic limb movements in sleep are a risk factor for silent SVD and perhaps for the development of clinical stroke.Citation:Ferri R, Cosentino FI, Moussouttas M, Lanuzza B, Aricò D, Bagai K, Wang L, McLaughlin B, Walters AS. Silent cerebral small vessel disease in restless legs syndrome. SLEEP 2016;39(7):1371–1377.
Source: Sleep - July 1, 2016 Category: Sleep Medicine Source Type: research

Sleep Is Critical for Remote Preconditioning-Induced Neuroprotection
Conclusions:These results suggest that sleep induced by remote preconditioning is both sufficient and necessary for its neuroprotective effects on stroke outcome.Citation:Brager AJ, Yang T, Ehlen JC, Simon RP, Meller R, Paul KN. Sleep is critical for remote preconditioning-induced neuroprotection.SLEEP 2016;39(11):2033–2040.
Source: Sleep - November 1, 2016 Category: Sleep Medicine Source Type: research

Sleep Duration and Chronic Diseases among US Adults Age 45 Years and Older: Evidence From the 2010 Behavioral Risk Factor Surveillance System
Conclusions:Sleep duration had U-shaped relationships with leading chronic diseases. Further prospective studies are needed to determine how mental health and maintenance of a normal weight may interact with sleep duration to prevent chronic diseases.Citation:Liu Y; Wheaton AG; Chapman DP; Croft JB. Sleep duration and chronic diseases among US adults age 45 years and older: evidence from the 2010 Behavioral Risk Factor Surveillance System. SLEEP 2013;36(10):1421-1427.
Source: Sleep - October 2, 2013 Category: Sleep Medicine Source Type: research

Sleep Duration and White Matter Quality in Middle-Aged Adults
Conclusions:Short sleep duration was associated with worse markers of white matter integrity in midlife. These mid-life differences in white matter may underlie the link between poor sleep and risk of dementia and stroke.Citation:Yaffe K, Nasrallah I, Hoang TD, Lauderdale DS, Knutson KL, Carnethon MR, Launer LJ, Lewis CE, Sidney S. Sleep duration and white matter quality in middle-aged adults.SLEEP 2016;39(9):1743–1747.
Source: Sleep - August 31, 2016 Category: Sleep Medicine Source Type: research

Long-Term Cost-Effectiveness of Upper Airway Stimulation for the Treatment of Obstructive Sleep Apnea: A Model-Based Projection Based on the STAR Trial
Conclusions:Relative to the acknowledged willingness-to-pay threshold of $50,000–$100,000/QALY, our results indicate upper airway stimulation is a cost-effective therapy in the U.S. healthcare system.Citation:Pietzsch JB, Liu S, Garner AM, Kezirian EJ, Strollo PJ. Long-term cost-effectiveness of upper airway stimulation for the treatment of obstructive sleep apnea: a model-based projection based on the STAR Trial. SLEEP 2015;38(5):735–744.
Source: Sleep - May 1, 2015 Category: Sleep Medicine Source Type: research

Obstructive Sleep Apnea as a Risk Factor for Cerebral White Matter Change in a Middle-Aged and Older General Population
Conclusions:Moderate to severe OSA is an independent risk factor for WMC in middle-aged and older individuals. Thus, early recognition and treatment of OSA could reduce the risk of stroke and vascular dementia.Citation:Kim H; Yun CH; Thomas RJ; Lee SH; Seo HS; Cho ER; Lee SK; Yoon DW; Suh S; Shin C. Obstructive sleep apnea as a risk factor for cerebral white matter change in a middle-aged and older general population. SLEEP 2013;36(5):709-715.
Source: Sleep - May 4, 2013 Category: Sleep Medicine Source Type: research

Sleep Apnea Cardiovascular Clinical Trials—Current Status and Steps Forward: The International Collaboration of Sleep Apnea Cardiovascular Trialists
This article summarizes the status of clinical trials evaluating the potential cardiovascular benefits of sleep apnea treatment and discusses the challenges of conducting such trials, and introduces the International Collaboration of Sleep Apnea Cardiovascular Trialists (INCOSACT), a clinical research collaboration formed to foster cardiovascular sleep research.Citation:Gottlieb DJ; Craig SE; Lorenzi-Filho G; Heeley E; Redline S; McEvoy RD; Durán-Cantolla J. Sleep apnea cardiovascular clinical trials— current status and steps forward: the International Collaboration of Sleep Apnea Cardiovascular Trialists. SLE...
Source: Sleep - July 2, 2013 Category: Sleep Medicine Source Type: research

Predictors of Long-Term Adherence to Continuous Positive Airway Pressure Therapy in Patients with Obstructive Sleep Apnea and Cardiovascular Disease in the SAVE Study
Conclusion:Continuous positive airway pressure use in patients with coexisting cardiovascular disease and moderate to severe obstructive sleep apnea decreases significantly over 12 months. This decline can be predicted by early patient experiences with continuous positive airway pressure (i.e., adherence and side effects at 1 month), raising the possibility that intensive early interventions could improve long-term continuous positive airway pressure compliance in this patient population.Clinical Trials Register:Clinical Trials, http://www.clinicaltrials.gov, NCT00738179.Citation:Chai-Coetzer CL; Luo YM; Antic NA; Zhang XL...
Source: Sleep - November 30, 2013 Category: Sleep Medicine Source Type: research

Circadian Variability of Fibrinolytic Markers and Endothelial Function in Patients with Obstructive Sleep Apnea
Conclusion:The presence of obstructive sleep apnea adversely affects circadian fibrinolytic balance with higher mean plasminogen activator inhibitor-1 activity and antigen, and significantly lower mean tissue-type plasminogen activator activity compared with controls. This perturbation may be an important mechanism for increased cardiovascular events in patients with obstructive sleep apnea. Intermittent hypoxia and changes in circadian clock gene activity in obstructive sleep apnea may be responsible for these findings and warrant further study. Favorable changes in fibrinolytic balance may underlie the reduction in cardi...
Source: Sleep - February 3, 2014 Category: Sleep Medicine Source Type: research

Sleep Impairment and Prognosis of Acute Myocardial Infarction: A Prospective Cohort Study
Conclusion:Results suggest sex-specific effects of impaired sleep that differ by short- and long-term prognosis. Sleep complaints are frequent, easily recognizable, and potentially manageable. Evaluation of sleep complaints may, even if they represent prognostic markers rather than risk factors, provide additional information in clinical risk assessment that could benefit secondary cardiovascular prevention.Citation:Clark A, Lange T, Hallqvist J, Jennum P, Rod NH. Sleep impairment and prognosis of acute myocardial infarction: a prospective cohort study. SLEEP 2014;37(5):851-858.
Source: Sleep - May 1, 2014 Category: Sleep Medicine Source Type: research

Effects of Obstructive Sleep Apnea and Obesity on Exercise Function in Children
Conclusions:Children with OSA are exercise limited due to a reduced cardiac output and VO2 peak at peak exercise capacity, independent of their weight status. Comorbid OSA can further decrease exercise performance in obese children.Citation:Evans CA, Selvadurai H, Baur LA, Waters KA. Effects of obstructive sleep apnea and obesity on exercise function in children. SLEEP 2014;37(6):1103-1110.
Source: Sleep - May 30, 2014 Category: Sleep Medicine Source Type: research