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The future of pyrogenicity testing: Phasing out the rabbit pyrogen test. A meeting report
Biologicals. 2023 Aug 27;84:101702. doi: 10.1016/j.biologicals.2023.101702. Online ahead of print.ABSTRACTThe rabbit pyrogen test (RPT) was the benchmark for pyrogenicity testing, but scientific advancements have provided innovative and humane methods, such as the in vitro monocyte-activation test (MAT). However, transitioning from the RPT to the MAT has been challenging. The European Directorate for the Quality of Medicines & HealthCare, the Council of Europe, and the European Partnership for Alternative Approaches to Animal Testing jointly hosted an international conference entitled "The future of pyrogenicity testin...
Source: Biologicals : Journal of the International Association of Biological Standardization - August 29, 2023 Category: Biotechnology Authors: Gwena ël Cirefice Katrin Sch ütte Ingo Spreitzer Emmanuelle Charton Shahjahan Shaid Laura Viviani Michelle Rubbrecht Irene Manou Source Type: research

3Rs implementation in veterinary vaccine batch-release testing: Current state-of-the-art and future opportunities. A webinar and workshop report
Biologicals. 2023 Jul 27;83:101695. doi: 10.1016/j.biologicals.2023.101695. Online ahead of print.ABSTRACTRegulatory authorities require veterinary batch-release testing to confirm vaccine potency and safety, but these tests have traditionally relied on large numbers of laboratory animals. Advances in vaccine research and development offer increasing opportunities to replace in vivo testing, and some stakeholders have made significant progress in incorporating 3Rs elements in quality control strategies. A three-part event series entitled "3Rs Implementation in Veterinary Vaccine Batch-Release Testing: Current state-of-the-...
Source: Biologicals : Journal of the International Association of Biological Standardization - July 29, 2023 Category: Biotechnology Authors: Laura Viviani Elisabeth Balks Sonja Beken Anna-Maria Brady Rick Clayton Florence Cliquet Liys Desmayanti Silvia Fragoeiro Terrie Jo Hamtak David John Carmen Jungba ëck M Kalaivani Imke Kross Catherine Lang Ni Made Ria Isriyanthi Laurent Mallet Catherine Source Type: research

Epidemiology-driven approaches to surveillance in HPAI-vaccinated poultry flocks aiming to demonstrate freedom from circulating HPAIV
Biologicals. 2023 Jul 24;83:101694. doi: 10.1016/j.biologicals.2023.101694. Online ahead of print.ABSTRACTIncursion pressure of high pathogenicity avian influenza viruses (HPAIV) by secondary spread among poultry holdings and/or from infected migratory wild bird populations increases worldwide. Vaccination as an additional layer of protection of poultry holdings using appropriately matched vaccines aims at reducing clinical sequelae of HPAIV infection, disrupting HPAIV transmission, curtailing economic losses and animal welfare problems and cutting exposure risks of zoonotic HPAIV at the avian-human interface. Products der...
Source: Biologicals : Journal of the International Association of Biological Standardization - July 26, 2023 Category: Biotechnology Authors: Timm Harder Sjaak de Wit Jose L Gonzales Jeremy H P Ho Paolo Mulatti Teguh Y Prajitno Arjan Stegeman Source Type: research

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