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Association between paraoxonase gene and stroke in the Han Chinese population
Conclusions: These findings indicate that polymorphisms of PON1 gene may be a risk factor of stroke.
Source: BMC Medical Genetics - Latest articles - January 28, 2013 Category: Genetics & Stem Cells Authors: Guojun ZhangWenjin LiZhiqiang LiHong LvYonghong RenRuimin MaXiaohong LiXixiong KangYongyong ShiYimin Sun Source Type: research

Lack of association between a functional variant of the BRCA-1 related associated protein (BRAP) gene and ischemic stroke
Conclusions: The BRAP polymorphism may not play an important role in ischemic stroke in the studied population.
Source: BMC Medical Genetics - Latest articles - January 28, 2013 Category: Genetics & Stem Cells Authors: Yi-Chu LiaoHsiu-Fen LinYuh-Cherng GuoChung-Hung ChenZhi-Zhang HuangSuh-Hang JuoRuey-Tay Lin Source Type: research

Association of interleukin-33 gene single nucleotide polymorphisms with ischemic stroke in north Chinese population
Conclusion: In this sample of patients, genetic variation of rs4742170 in IL33 is significantly associated with the developing of ischemic stroke.
Source: BMC Medical Genetics - Latest articles - October 9, 2013 Category: Genetics & Stem Cells Authors: Liang GuoXinghu ZhouXiaofan GuoXingang ZhangYingxian Sun Source Type: research

Association between genetic polymorphisms of cytochrome P450 2C19 and the risk of cerebral ischemic stroke in Chinese
Conclusions: The AA genotype and A allele of CYP2C19 G681A may be related to the occurrence and recurrence of cerebral ischemic stroke.
Source: BMC Medical Genetics - Latest articles - July 17, 2014 Category: Genetics & Stem Cells Authors: Shuzhen GuYan SunRuifa HanLin WangDongliang WangJizuo WangXin Li Source Type: research

Involvement of polymorphisms of the nerve growth factor and its receptor encoding genes in the etiopathogenesis of ischemic stroke
Despite the important role of the nerve growth factor in the survival and maintenance of neurons in ischemic stroke, data regarding the relationships between variations in the encoding gene and stroke are lack...
Source: BMC Medical Genetics - March 2, 2018 Category: Genetics & Stem Cells Authors: Ani Stepanyan, Roksana Zakharyan, Arsen Simonyan, Gohar Tsakanova and Arsen Arakelyan Tags: Research article Source Type: research

Deep vein thrombosis inhibitor may play a therapeutic role in post-stroke patients
Deep vein thrombosis (DVT) is associated with stroke. Here, we hypothesize that genes associated with DVT may also play roles in the development of stroke.
Source: BMC Medical Genetics - October 22, 2020 Category: Genetics & Stem Cells Authors: Xixi Xiang, Di Yuan, Peiyan Kong, Ting Chen, Han Yao, Shijia Lin, Xi Zhang and Hongbao Cao Tags: Research Source Type: research

Association study of C-reactive protein associated gene HNF1A with ischemic stroke in Chinese population
Ischemic stroke is a life-threatening condition due to obstructed blood supply of the brain. Elevation of plasma C-reactive protein, an important inflammatory marker, was known to associate with increased risk...
Source: BMC Medical Genetics - July 26, 2016 Category: Genetics & Stem Cells Authors: Haibin Shi, Song Leng, Hui Liang, Yan Zheng and Lidian Chen Source Type: research

Genetic variants in CYP4F2 were significantly correlated with susceptibility to ischemic stroke
Ischemic stroke (IS) is a serious cardiovascular disease and is associated with several single nucleotide polymorphisms (SNPs). However, the role of Cytochrome P450 family 4 subfamily F member 2 (CYP4F2) gene in ...
Source: BMC Medical Genetics - September 11, 2019 Category: Genetics & Stem Cells Authors: Yuan Wu, Junjie Zhao, Yonglin Zhao, Tingqin Huang, Xudong Ma, Honggang Pang and Ming Zhang Tags: Research article Source Type: research

Identification of novel biomarkers in ischemic stroke: a genome-wide integrated analysis
Ischemic Stroke (IS) is the most common neurological emergency disease and has become the second most frequent cause of death after coronary artery disease in 2015. Owing to its high fatality rate and narrow t...
Source: BMC Medical Genetics - March 30, 2020 Category: Genetics & Stem Cells Authors: Qizhi Xie, Xiaoyun Zhang, Sijia Peng, Jingjing Sun, Xiao Chen, Yuanfei Deng and Li Yi Tags: Research article Source Type: research

The impact of coronary artery disease risk loci on ischemic heart failure severity and prognosis: association analysis in the COntrolled ROsuvastatin multiNAtional trial in heart failure (CORONA)
Conclusion: Genetic variants strongly associated with CAD risk are not associated with the severity and outcome of ischemic heart failure. The observed association of the 1p13.3 locus with all-cause mortality requires confirmation in further studies.
Source: BMC Medical Genetics - December 21, 2014 Category: Genetics & Stem Cells Authors: Vincent HaverNiek VerweijJohn KjekshusJayne FoxHans WedelJohn WikstrandWiek van GilstRudolf de BoerDirk van VeldhuisenPim van der Harst Source Type: research

Sequence variation in telomerase reverse transcriptase (TERT) as a determinant of risk of cardiovascular disease: the Atherosclerosis Risk in Communities (ARIC) study
Conclusions: Replication in additional population-based samples combined with genotyping of polymorphisms in other genes involved in maintenance of telomere length may help to determine whether genetic variants associated with telomere homeostasis influence the risk of cardiovascular disease in middle-aged adults.
Source: BMC Medical Genetics - July 23, 2015 Category: Genetics & Stem Cells Authors: Jan BresslerNora FranceschiniEllen DemerathThomas MosleyAaron FolsomEric Boerwinkle Source Type: research

Microsomal triglyceride transfer protein -164 T > C gene polymorphism and risk of cardiovascular disease: results from the EPIC-Potsdam case-cohort study
Conclusions: Our study suggests an interaction between MTTP -164T> C functional polymorphism with total cholesterol levels. Thereby risk allele carriers with low cholesterol levels may be predisposed to an increased risk of developing CVD, which seems to be abolished among risk allele carriers with high cholesterol levels.
Source: BMC Medical Genetics - Latest articles - January 29, 2013 Category: Genetics & Stem Cells Authors: Romina di GiuseppeSonali PechlivanisEva FisherMaria ArreguiBeate WeikertSven KnüppelBrian BuijsseAndreas FritscheStefan WillichHans-Georg JoostHeiner BoeingSusanne MoebusCornelia Weikert Source Type: research

Microsomal triglyceride transfer protein -164 T¿>¿C gene polymorphism and risk of cardiovascular disease: results from the EPIC-Potsdam case-cohort study
Background: The microsomal triglyceride transfer protein (MTTP) is encoded by the MTTP gene that is regulated by cholesterol in humans. Previous studies investigating the effect of MTTP on ischemic heart disease have produced inconsistent results. Therefore, we have tested the hypothesis that the rare allele of the -164T > C polymorphism in MTTP alters the risk of cardiovascular disease (CVD), depending on the cholesterol levels. Methods: The -164T> C polymorphism was genotyped in a case-cohort study (193 incident myocardial infarction (MI) and 131 incident ischemic stroke (IS) cases and 1 978 non-cases) nested within ...
Source: BMC Medical Genetics - Latest articles - January 29, 2013 Category: Genetics & Stem Cells Authors: Romina di GiuseppeSonali PechlivanisEva FisherMaria ArreguiBeate WeikertSven KnüppelBrian BuijsseAndreas FritscheStefan WillichHans-Georg JoostHeiner BoeingSusanne MoebusCornelia Weikert Source Type: research

Hypertension after preeclampsia and relation to the C1114G polymorphism (rs4606) in RGS2: data from the Norwegian HUNT2 study
Conclusion: Women carrying the rs4606 CG or GG genotype are at elevated risk for developing hypertension after delivery. Physical activity may interact with the association. Preeclampsia remains an independent risk factor for subsequent hypertension after adjusting for this polymorphism and classical CVD risk factors.
Source: BMC Medical Genetics - Latest articles - March 5, 2014 Category: Genetics & Stem Cells Authors: Anne Stine KvehaugenØyvind MelienOddgeir HolmenHannele LaivuoriRalf DechendAnne Cathrine Staff Source Type: research