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Total 32 results found since Jan 2013.

A Cross‐Sectional Cohort Study of Cerebrovascular Disease and Late Effects After Radiation Therapy for Craniopharyngioma
ConclusionsPatients with craniopharyngioma treated with RT have a high prevalence of stroke and vascular abnormalities, particularly those with low HDL and longer duration of time since RT. There is a trend to suggest that continual GH replacement may reduce the risk of stroke. These patients should undergo careful monitoring and aggressive modification of stroke risk factors.
Source: Pediatric Blood and Cancer - January 12, 2016 Category: Cancer & Oncology Authors: Andrea C. Lo, A. Fuchsia Howard, Alan Nichol, Haroon Hasan, Monty Martin, Manraj Heran, Karen Goddard Tags: Research Article Source Type: research

Frequency of paroxysmal nocturnal hemoglobinuria clones by multiparametric flow cytometry in pediatric aplastic anemia patients of Indian ethnic origin
ConclusionsA lower frequency but moderate/large‐sized PNH clones were seen in our pediatric AA population, compared to western data. FLAER‐based FCM screening significantly improved the detection of PNH clones. We recommend routine FLAER‐based screening of PNH in pediatric AA patients. Pediatr Blood Cancer 2015; 9999:XX–XX © 2015 Wiley Periodicals, Inc.
Source: Pediatric Blood and Cancer - July 31, 2015 Category: Cancer & Oncology Authors: Sreejesh Sreedharanunni, Man Updesh Singh Sachdeva, Parveen Bose, Neelam Varma, Deepak Bansal, Amita Trehan Tags: Research Article Source Type: research

Contribution of sickle cell disease to the pediatric stroke burden among hospital discharges of African‐Americans—United States, 1997–2012
ConclusionsSCD is a leading risk factor to pediatric stroke in African‐American children. Reducing the number of strokes among children with SCD would have a significant impact on the rate of strokes among African‐American children. Preventative intervention may be modifying initial age of presentation of stroke in children with SCD. Pediatr Blood Cancer © 2015 Wiley Periodicals, Inc.
Source: Pediatric Blood and Cancer - July 14, 2015 Category: Cancer & Oncology Authors: Charlotte Baker, Althea M. Grant, Mary G. George, Scott D. Grosse, Thomas V. Adamkiewicz Tags: Research Article Source Type: research

Hydroxyurea use in prevention of stroke recurrence in children with sickle cell disease in a developing country: A cost effectiveness analysis
We undertook a cost effectiveness analysis (CEA) of hydroxyurea (HU) in preventing stroke recurrence and/or death. We followed 43 children with sickle cell disease from 2000 to 2009 after having a first clinical stroke, of whom 10 opted for HU therapy. HU use led to decreased stroke recurrence and death without significantly increasing the annual cost of care per patient (J$83,250 vs. J$76,901, P = 0.491). The incremental cost effectiveness ratio (ICER) for prevention of stroke recurrence amounted to J$169,238 (US$1,900), while that for death prevention equalled J$635,843 (US$7,140). HU may be recommended when safe and...
Source: Pediatric Blood and Cancer - April 30, 2015 Category: Cancer & Oncology Authors: Colette Cunningham‐Myrie, Abdullahi Abdulkadri, Andre Waugh, Susanna Bortolusso Ali, Lesley‐Gaye King, Jennifer Knight‐Madden, Marvin Reid Tags: Brief Report Source Type: research

Hydroxyurea lowers transcranial Doppler flow velocities in children with sickle cell anaemia in a Nigerian cohort
ConclusionHU appears to significantly reduce TCD velocities in Nigerian children with SCA and elevated velocities ≥170 cm/sec with beneficial effect on the haematological profile. HU may provide an effective approach to primary stroke prevention, particularly in Africa. Pediatr Blood Cancer © 2015 Wiley Periodicals, Inc.
Source: Pediatric Blood and Cancer - April 2, 2015 Category: Cancer & Oncology Authors: IkeOluwa Lagunju, Biobele J. Brown, Olugbemiro Sodeinde Tags: Research Article Source Type: research

Primary stroke prevention in Nigerian children with sickle cell disease (SPIN): Challenges of conducting a feasibility trial
ConclusionA hydroxyurea trial (NCT01801423) for children with SCD is feasible in sub‐Saharan Africa; however, extensive training and resources are needed to build a global patient oriented multi‐disciplinary research team with a common purpose. Pediatr Blood Cancer. © 2014 Wiley Periodicals, Inc.
Source: Pediatric Blood and Cancer - November 14, 2014 Category: Cancer & Oncology Authors: Najibah A. Galadanci, Shehu U. Abdullahi, Musa A. Tabari, Shehi Abubakar, Raymond Belonwu, Auwal Salihu, Kathleen Neville, Fenella Kirkham, Baba Inusa, Yu Shyr, Sharon Phillips, Adetola A. Kassim, Lori C. Jordan, Muktar H. Aliyu, Brittany V. Covert, Micha Tags: Research Article Source Type: research

Implementation of transcranial Doppler ultrasonography screening and primary stroke prevention in urban and rural sickle cell disease populations
ConclusionsWe report here data describing primary stroke prophylaxis in rural patients. SOC rates are similar between the two clinical settings. While implementation of primary stroke prevention in rural patients was difficult, rural TCD screening is feasible and can achieve SOC equal to that in an urban setting. This suggests that barriers exist in provided primary stroke prevention to all patients. Pediatr Blood Cancer © 2014 Wiley Periodicals, Inc.
Source: Pediatric Blood and Cancer - November 8, 2014 Category: Cancer & Oncology Authors: Samiya Hussain, Fenwick Nichols, Latanya Bowman, Hongyan Xu, Cindy Neunert Tags: Research Article Source Type: research

Endothelial nitric oxide synthase gene intron 4 VNTR polymorphism in sickle cell disease: Relation to vasculopathy and disease severity
ConclusionsWe suggest that eNOS intron 4 gene polymorphism is related to endothelial dysfunction and vasculopathy in SCD and could provide utility for prediction of increased susceptibility to vascular complications. Pediatr Blood Cancer © 2014 Wiley Periodicals, Inc.
Source: Pediatric Blood and Cancer - September 27, 2014 Category: Cancer & Oncology Authors: Azza Abdel Gawad Tantawy, Amira Abdel Moneam Adly, Eman Abdel Rahman Ismail, Shereen Hussiny Aly Tags: Research Article Source Type: research

Capacity building and stroke risk assessment in Nigerian children with sickle cell anaemia
ConclusionEffective capacity building of middle level manpower is feasible and can provide a credible TCD screening service to communities with a high demand and a shortage of trained professionals. The pattern of TCD abnormalities seen in Africa are comparable to those obtained in several previous worldwide reports. Pediatr Blood Cancer © 2014 Wiley Periodicals, Inc.
Source: Pediatric Blood and Cancer - August 30, 2014 Category: Cancer & Oncology Authors: Kofo Soyebi, Titilope Adeyemo, Oyesola Ojewunmi, Funmi James, Kunle Adefalujo, Olu Akinyanju Tags: Research Article Source Type: research

Risk and resilience factors for grade retention in youth with sickle cell disease
ConclusionsThese findings suggest the need for interventions that promote connectedness and achievement‐orientation in families of youth with SCD. Research is also needed to further explore other possible risk or resilience factors for grade retention in this population, such as school absenteeism. Pediatr Blood Cancer © 2014 Wiley Periodicals, Inc.
Source: Pediatric Blood and Cancer - February 12, 2014 Category: Cancer & Oncology Authors: Rebecca J. Ladd, Cecelia R. Valrie, Christy M. Walcott Tags: Research Article Source Type: research

Comprehensive integrated care for patients with sickle cell disease in a remote aboriginal tribal population in southern India
ConclusionHigh quality comprehensive care for SCD can be delivered for a low income, aboriginal population in India through a community driven network of care. This model can serve as a template for healthcare delivery for SCD in low‐income communities. Pediatr Blood Cancer © 2013 Wiley Periodicals, Inc.
Source: Pediatric Blood and Cancer - December 18, 2013 Category: Cancer & Oncology Authors: Vivek Nimgaonkar, Lakshmanan Krishnamurti, Hari Prabhakar, Nandakumar Menon Tags: Research Article Source Type: research

Does an Alzheimer's disease susceptibility gene influence the cognitive effects of cancer therapy?
Abstract The apolipoprotein E (APOE) e4 allele is the most prevalent genetic risk factor for Alzheimer's disease (AD). APOE e4 carriers suffer greater morbidity from head trauma, stroke, and carbon monoxide poisoning, yet possible interactions between APOE genotype and cancer therapy on cognition are unclear. Neuropathological and biomarker studies of young asymptomatic APOE e4 carriers that show elevated neocortical amyloid and medial temporal neurofibrillary tangles and longitudinal neuropsychological studies that show accelerated memory decline beginning around age 55–60 years define preclinical AD and have set the st...
Source: Pediatric Blood and Cancer - September 17, 2013 Category: Cancer & Oncology Authors: Richard J. Caselli Tags: Review Source Type: research

Transcranial doppler and brain MRI in children with sickle cell disease and high hemoglobin F levels
ConclusionThe mild phenotype among Kuwaiti patients with SCD is reflected in normal TCD velocities and a low prevalence of SBI in children with the disease. Pediatr Blood Cancer © 2013 Wiley Periodicals, Inc.
Source: Pediatric Blood and Cancer - September 11, 2013 Category: Cancer & Oncology Authors: Akram Asbeutah, Renu Gupta, Osama Al‐Saeid, Sam Ashebu, Sundus Al‐Sharida, Ali Mullah‐Ali, Nada Yousef Mustafa, Adekunle Adekile Tags: Research Article Source Type: research

Chronic blood transfusion for primary and secondary stroke prevention in Nigerian children with sickle cell disease: A 5‐year appraisal
ConclusionHigh economic costs, unavailability of blood, need to regularly seek for blood donors, cultural beliefs, and high frequency of transfusion reactions are major challenges to a successful CBT program in Nigeria. There is a need for government subsidy on blood transfusions and improved efforts towards provision of safe and affordable blood. Pediatr Blood Cancer. © 2013 Wiley Periodicals, Inc.
Source: Pediatric Blood and Cancer - August 19, 2013 Category: Cancer & Oncology Authors: I.A. Lagunju, B.J. Brown, O.O. Sodeinde Tags: Research Article Source Type: research

Transcranial Doppler Velocity and Brain MRI/MRA Changes in Children With Sickle Cell Anemia on Chronic Transfusions to Prevent Primary Stroke
ConclusionsFor children with SCA and abnormal TCD velocities, transfusions lower TCD velocities and help prevent stroke, but do not always result in normal velocities or protect against progression of cerebral vasculopathy. Improved adherence to transfusion goals may improve on‐treatment TCD velocities. Pediatr Blood Cancer 2013;9999:XX–XX. © 2013 Wiley Periodicals, Inc.
Source: Pediatric Blood and Cancer - April 26, 2013 Category: Cancer & Oncology Authors: Vivien A. Sheehan, Eileen N. Hansbury, Matthew P. Smeltzer, Gail Fortner, M. Beth McCarville, Banu Aygun Tags: Research Article Source Type: research