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Specialty: Cancer & Oncology
Source: Pediatric Blood and Cancer

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Total 32 results found since Jan 2013.

Increased complications of chronic erythrocytapheresis compared with manual exchange transfusions in children and adolescents with sickle cell disease
ConclusionaRBCX may have increased complication risks compared with MET for chronic transfusion therapy in SCD. Risks and benefits of aRBCX and MET should be considered when selecting a chronic transfusion modality. Transfusion therapy modalities should be compared in prospective studies for stroke prevention in children with SCD.
Source: Pediatric Blood and Cancer - May 19, 2017 Category: Cancer & Oncology Authors: Deborah Woods, Robert J. Hayashi, Michael M. Binkley, Gianna W. Sparks, Monica L. Hulbert Tags: RESEARCH ARTICLE Source Type: research

Age‐related treatment patterns in sickle cell disease patients and the associated sickle cell complications and healthcare costs
ConclusionsPatients transitioning to adult care received less transfusions and hydroxyurea, less ICT when eligible for chelation therapy, had higher healthcare costs and suffered from more frequent SCD related complications than pediatric patients. These findings highlight the changes in treatment patterns corresponding to transition to adult care. Pediatr Blood Cancer © 2013 Wiley Periodicals, Inc.
Source: Pediatric Blood and Cancer - January 17, 2013 Category: Cancer & Oncology Authors: Morey A. Blinder, Francis Vekeman, Medha Sasane, Alex Trahey, Carole Paley, Mei Sheng Duh Tags: Research Article Source Type: research

Transcranial doppler and brain MRI in children with sickle cell disease and high hemoglobin F levels
ConclusionThe mild phenotype among Kuwaiti patients with SCD is reflected in normal TCD velocities and a low prevalence of SBI in children with the disease. Pediatr Blood Cancer © 2013 Wiley Periodicals, Inc.
Source: Pediatric Blood and Cancer - September 11, 2013 Category: Cancer & Oncology Authors: Akram Asbeutah, Renu Gupta, Osama Al‐Saeid, Sam Ashebu, Sundus Al‐Sharida, Ali Mullah‐Ali, Nada Yousef Mustafa, Adekunle Adekile Tags: Research Article Source Type: research

Does an Alzheimer's disease susceptibility gene influence the cognitive effects of cancer therapy?
Abstract The apolipoprotein E (APOE) e4 allele is the most prevalent genetic risk factor for Alzheimer's disease (AD). APOE e4 carriers suffer greater morbidity from head trauma, stroke, and carbon monoxide poisoning, yet possible interactions between APOE genotype and cancer therapy on cognition are unclear. Neuropathological and biomarker studies of young asymptomatic APOE e4 carriers that show elevated neocortical amyloid and medial temporal neurofibrillary tangles and longitudinal neuropsychological studies that show accelerated memory decline beginning around age 55–60 years define preclinical AD and have set the st...
Source: Pediatric Blood and Cancer - September 17, 2013 Category: Cancer & Oncology Authors: Richard J. Caselli Tags: Review Source Type: research

Comprehensive integrated care for patients with sickle cell disease in a remote aboriginal tribal population in southern India
ConclusionHigh quality comprehensive care for SCD can be delivered for a low income, aboriginal population in India through a community driven network of care. This model can serve as a template for healthcare delivery for SCD in low‐income communities. Pediatr Blood Cancer © 2013 Wiley Periodicals, Inc.
Source: Pediatric Blood and Cancer - December 18, 2013 Category: Cancer & Oncology Authors: Vivek Nimgaonkar, Lakshmanan Krishnamurti, Hari Prabhakar, Nandakumar Menon Tags: Research Article Source Type: research

Risk and resilience factors for grade retention in youth with sickle cell disease
ConclusionsThese findings suggest the need for interventions that promote connectedness and achievement‐orientation in families of youth with SCD. Research is also needed to further explore other possible risk or resilience factors for grade retention in this population, such as school absenteeism. Pediatr Blood Cancer © 2014 Wiley Periodicals, Inc.
Source: Pediatric Blood and Cancer - February 12, 2014 Category: Cancer & Oncology Authors: Rebecca J. Ladd, Cecelia R. Valrie, Christy M. Walcott Tags: Research Article Source Type: research

Endothelial nitric oxide synthase gene intron 4 VNTR polymorphism in sickle cell disease: Relation to vasculopathy and disease severity
ConclusionsWe suggest that eNOS intron 4 gene polymorphism is related to endothelial dysfunction and vasculopathy in SCD and could provide utility for prediction of increased susceptibility to vascular complications. Pediatr Blood Cancer © 2014 Wiley Periodicals, Inc.
Source: Pediatric Blood and Cancer - September 27, 2014 Category: Cancer & Oncology Authors: Azza Abdel Gawad Tantawy, Amira Abdel Moneam Adly, Eman Abdel Rahman Ismail, Shereen Hussiny Aly Tags: Research Article Source Type: research

Frequency of paroxysmal nocturnal hemoglobinuria clones by multiparametric flow cytometry in pediatric aplastic anemia patients of Indian ethnic origin
ConclusionsA lower frequency but moderate/large‐sized PNH clones were seen in our pediatric AA population, compared to western data. FLAER‐based FCM screening significantly improved the detection of PNH clones. We recommend routine FLAER‐based screening of PNH in pediatric AA patients. Pediatr Blood Cancer 2015; 9999:XX–XX © 2015 Wiley Periodicals, Inc.
Source: Pediatric Blood and Cancer - July 31, 2015 Category: Cancer & Oncology Authors: Sreejesh Sreedharanunni, Man Updesh Singh Sachdeva, Parveen Bose, Neelam Varma, Deepak Bansal, Amita Trehan Tags: Research Article Source Type: research

Reduction in Overt and Silent Stroke Recurrence Rate Following Cerebral Revascularization Surgery in Children with Sickle Cell Disease and Severe Cerebral Vasculopathy
ConclusionsThe rate of overt and silent infarct recurrence was significantly lower following indirect cerebral revascularization. A prospective study of cerebral revascularization in children with SCD is needed.
Source: Pediatric Blood and Cancer - April 21, 2016 Category: Cancer & Oncology Authors: Erin M. Hall, Jeffrey Leonard, Jodi L. Smith, Kristin P. Guilliams, Michael Binkley, Robert J. Fallon, Monica L. Hulbert Tags: Research Article Source Type: research

Cranial epidural hematomas: A case series and literature review of this rare complication associated with sickle cell disease
ConclusionsAlthough rare, cranial epidural hematoma can be fatal and should be considered in patients with acute neurological symptoms.
Source: Pediatric Blood and Cancer - September 12, 2016 Category: Cancer & Oncology Authors: Jennifer Hamm, Nisha Rathore, Pearlene Lee, Zachary LeBlanc, Jeffrey Lebensburger, Emily Riehm Meier, Janet L. Kwiatkowski Tags: Research Article Source Type: research

Genotypes and phenotypes of protein S deficiency in Thai children with thromboembolism
Abstract The prevalence of protein S (PS) deficiency in Asian patients with venous thromboembolism is around 8–30%, higher than that in Caucasian populations. The present study reports the genotypes (including one novel mutation) and phenotypes of children with PS deficiency at a tertiary care institute. A total of six patients were included, three with arterial ischemic stroke, two with cerebral venous sinus thrombosis, and one with deep vein thrombosis. PS mutations were identified in four patients: p.R355C, p.G336D, p.E67A, and p.N188KfsX9. p.N188KfsX9 is a novel mutation with less than 20% PS activity noted in heterozygotes.
Source: Pediatric Blood and Cancer - October 16, 2016 Category: Cancer & Oncology Authors: Patcharee Komwilaisak, Werasak Sasanakul, Ampaiwan Chuansumrit, Somjai Kanjanapongkul, Somporn Wangruangsathit, Apasri Lusawat, Pimlak Charoenkwan, Nongnuch Sirachainan Tags: Brief Report Source Type: research

The clinical presentation and genotype of protein C deficiency with double mutations of the protein C gene
ConclusionsThe genotype of double‐PROC mutants might show less diversity than heterozygous mutants in terms of the timing of the onset of thrombophilia (newborn onset or late onset).
Source: Pediatric Blood and Cancer - January 22, 2017 Category: Cancer & Oncology Authors: Hirofumi Inoue, Shin ‐ichi Terachi, Takeshi Uchiumi, Tetsuji Sato, Michiyo Urata, Masataka Ishimura, Yui Koga, Taeko Hotta, Toshiro Hara, Dongchon Kang, Shouichi Ohga Tags: Research Article Source Type: research

An analysis of inpatient pediatric sickle cell disease: Incidence, costs, and outcomes
ConclusionInpatient hospitalizations for secondary manifestations of pediatric SCD were associated with significant healthcare expenditures. Patients with an increased statistical risk for death during hospitalization included Caucasians with SCD complications of ACS and VOC, and patients <1‐year‐old with ACS. Further research is needed to substantiate the associated clinical significance of these findings.
Source: Pediatric Blood and Cancer - August 12, 2017 Category: Cancer & Oncology Authors: Laura M. Bou ‐Maroun, Fabien Meta, Curtis J. Hanba, Andrew D. Campbell, Gregory A. Yanik Tags: RESEARCH ARTICLE Source Type: research

Deficiency of ADA2 mimicking autoimmune lymphoproliferative syndrome in the absence of livedo reticularis and vasculitis
We present a 5‐year‐old female who presented with features that mimicked autoimmune lymphoproliferative syndrome (ALPS) in the absence of classic features of DADA2. Exome sequencing identified a novel homozygous splicing variant in ADA2 c.882‐2A > G. Patient responded to anti‐ tumor necrosis factor medication and is in complete remission. Hematologists should be aware of various hematological presentations of DADA2, including ALPS‐like disorder, that might lack vasculitis and livedo reticularis to prevent delay in initiating optimal therapy.
Source: Pediatric Blood and Cancer - December 22, 2017 Category: Cancer & Oncology Authors: Abdulrahman Alsultan, Enas Basher, Jubran Alqanatish, Reem Mohammed, Majid Alfadhel Tags: BRIEF REPORT Source Type: research

Annual stroke incidence in Nigerian children with sickle cell disease and elevated TCD velocities treated with hydroxyurea
Pediatric Blood&Cancer, EarlyView.
Source: Pediatric Blood and Cancer - May 24, 2018 Category: Cancer & Oncology Authors: IkeOluwaLagunju , B.J.Brown , A.O.Oyinlade , A.Asinobi , J.Ibeh , A.Esione , O.O.Sodeinde Source Type: research