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Specialty: Neurology
Source: Annals of Neurology
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Total 175 results found since Jan 2013.
Final Results of the RHAPSODY trial: A multi ‐center, Phase 2 trial using a continual reassessment method to determine the safety and tolerability of 3K3A‐APC, a Recombinant Variant of Human Activated Protein C, in combination with tissue plasminogen activator, mechanical thrombectomy or both in moderate to severe acute ischemic stroke
This article is protected by copyright. All rights reserved.
Source: Annals of Neurology - November 18, 2018 Category: Neurology Authors: Patrick Lyden,
Kent E. Pryor,
Christopher S. Coffey,
Merit Cudkowicz,
Robin Conwit,
Ashutosh Jadhav,
Robert N. Sawyer,
Jan Claassen,
Opeolu Adeoye,
Shlee Song,
Peter Hannon,
Natalia S. Rost,
Archana Hinduja,
Michel Torbey,
Jin ‐Moo Lee,
C Tags: Research Article Source Type: research
Clinical outcomes depending on acute blood pressure after cerebral hemorrhage
This article is protected by copyright. All rights reserved.
Source: Annals of Neurology - November 12, 2018 Category: Neurology Authors: Kazunori Toyoda,
Masatoshi Koga,
Haruko Yamamoto,
Lydia Foster,
Yuko Y Palesch,
Yongjun Wang,
Nobuyuki Sakai,
Takayuki Hara,
Chung Y Hsu,
Ryo Itabashi,
Shoichiro Sato,
Mayumi Fukuda,
Thorsten Steiner,
Byung ‐Woo Yoon,
Daniel F Hanley,
Adn Tags: Research Article Source Type: research
Thalamic Strokes that Severely Impair Arousal Extend into the Brainstem
This article is protected by copyright. All rights reserved.
Source: Annals of Neurology - November 12, 2018 Category: Neurology Authors: Joseph Hindman,
Mark D. Bowren,
Joel Bruss,
Brad Wright,
Joel C. Geerling,
Aaron D. Boes Tags: Brief Communication Source Type: research
Brain ‐State Dependent Stimulation boosts functional recovery following stroke
This article is protected by copyright. All rights reserved.
Source: Annals of Neurology - November 8, 2018 Category: Neurology Authors: Natalie Mrachacz ‐Kersting,
Andrew J.T. Stevenson,
Helle R. M. Jørgensen,
Kåre Eg Severinsen,
Susan Aliakbaryhosseinabadi,
Ning Jiang,
Dario Farina Tags: Research Article Source Type: research
Fingolimod enhances the efficacy of delayed alteplase administration in acute ischemic stroke by promoting anterograde reperfusion and retrograde collateral flow
ObjectiveThe present study was undertaken to determine the efficacy of coadministration of fingolimod with alteplase in acute ischemic stroke patients in a delayed time window.MethodsThis was a prospective, randomized, open ‐label, blinded endpoint clinical trial, enrolling patients with internal carotid artery or middle cerebral artery proximal occlusion within 4.5 to 6 hours from symptom onset. Patients were randomly assigned to receive alteplase alone or alteplase with fingolimod. All patients underwent pretreatme nt and 24‐hour noncontrast computed tomography (CT)/perfusion CT/CT angiography. The coprimary endpoint...
Source: Annals of Neurology - November 2, 2018 Category: Neurology Authors: De ‐Cai Tian,
Kaibin Shi,
Zilong Zhu,
Jia Yao,
Xiaoxia Yang,
Lei Su,
Sheng Zhang,
Meixia Zhang,
Rayna J. Gonzales,
Qiang Liu,
DeRen Huang,
Michael F. Waters,
Kevin N. Sheth,
Andrew F. Ducruet,
Ying Fu,
Min Lou,
Fu‐Dong Shi Tags: Research Article Source Type: research
Genome ‐Wide Meta‐analysis identifies three novel loci associated with stroke
Annals of Neurology,Volume 0, Issue ja, -Not available-.
Source: Annals of Neurology - November 1, 2018 Category: Neurology Authors: Rainer Malik,
Kristiina Rannikm äe,
Matthew Traylor,
Marios K Georgakis,
Muralidharan Sargurupremraj,
Hugh S Markus,
Jemma C Hopewell,
Stephanie Debette,
Cathie LM Sudlow,
Martin Dichgans,
for the MEGASTROKE consortium and the International Str Source Type: research
Development of a cerebrovascular magnetic resonance imaging biomarker for cognitive aging
ObjectiveRecent availability of amyloid and tau positron emission tomography (PET) has provided us with a unique opportunity to measure the association of systemic vascular health with brain health after accounting for the impact of Alzheimer disease (AD) pathologies. We wanted to quantify early cerebrovascular health –related magnetic resonance imaging brain measures (structure, perfusion, microstructural integrity) and evaluate their utility as a biomarker for cerebrovascular health.MethodsWe used 2 independent samples (discovery, n = 390; validation, n = 1,035) of individuals, aged ≥ 60 years, along the...
Source: Annals of Neurology - October 25, 2018 Category: Neurology Authors: Prashanthi Vemuri,
Timothy G. Lesnick,
Scott A. Przybelski,
Jonathan Graff ‐Radford,
Robert I. Reid,
Val J. Lowe,
Samantha M. Zuk,
Matthew L. Senjem,
Christopher G. Schwarz,
Jeffrey L. Gunter,
Kejal Kantarci,
Mary M. Machulda,
Michelle M. Mi Tags: Research Article Source Type: research
Neuroimaging and clinical outcomes of oral anticoagulant –associated intracerebral hemorrhage
ObjectiveWhether intracerebral hemorrhage (ICH) associated with non –vitamin K antagonist oral anticoagulants (NOAC‐ICH) has a better outcome compared to ICH associated with vitamin K antagonists (VKA‐ICH) is uncertain.MethodsWe performed a systematic review and individual patient data meta ‐analysis of cohort studies comparing clinical and radiological outcomes between NOAC‐ICH and VKA‐ICH patients. The primary outcome measure was 30‐day all‐cause mortality. All outcomes were assessed in multivariate regression analyses adjusted for age, sex, ICH location, and intraventricul ar hemorrhage extension.Results...
Source: Annals of Neurology - October 25, 2018 Category: Neurology Authors: Georgios Tsivgoulis,
Duncan Wilson,
Aristeidis H. Katsanos,
Jo ão Sargento‐Freitas,
Cláudia Marques‐Matos,
Elsa Azevedo,
Tomohide Adachi,
Christian Brelie,
Yoshifusa Aizawa,
Hiroshi Abe,
Hirofumi Tomita,
Ken Okumura,
Joji Hagii,
David J Tags: Research Article Source Type: research
Hypoperfusion ratio predicts infarct growth during transfer for thrombectomy
We hypothesized that automated assessment of collaterals on computed tomography perfusion can predict the rate of infarct growth during transfer from a primary to a comprehensive stroke center for endovascular stroke treatment. We identified consecutive patients (N = 28) and assessed their collaterals based on the hypoperfusion intensity ratio (HIR) prior to transfer. Infarct growth rate was strongly correlated with HIR (r = 0.78,p < 0.001). Receiver operating characteristic analysis identified HIR ≥ 0.5 as optimal for predicting infarct growth. Patients with HIR ≥ 0.5 had a median infarct grow...
Source: Annals of Neurology - October 16, 2018 Category: Neurology Authors: Adrien Guenego,
Michael Mlynash,
Soren Christensen,
Stephanie Kemp,
Jeremy J. Heit,
Maarten G. Lansberg,
Gregory W. Albers Tags: Brief Communication Source Type: research
Fingolimod Enhances the Efficacy of Delayed Alteplase Administration in Acute Ischemic Stroke by Promoting Anterograde Reperfusion and Retrograde Collateral Flow
Annals of Neurology,Volume 0, Issue ja, -Not available-.
Source: Annals of Neurology - October 8, 2018 Category: Neurology Authors: De ‐Cai Tian,
Kaibin Shi,
Zilong Zhu,
Jia Yao,
Xiaoxia Yang,
Lei Su,
Sheng Zhang,
Meixia Zhang,
Rayna J. Gonzales,
Qiang Liu,
DeRen Huang,
Michael F. Waters,
Kevin N. Sheth,
Andrew F. Ducruet,
Ying Fu,
Min Lou,
Fu‐Dong Shi Source Type: research
N ‐acetylcysteine targets 5 lipoxygenase‐derived, toxic lipids and can synergize with PGE2 to inhibit ferroptosis and improve outcomes following hemorrhagic stroke in mice
Annals of Neurology,Volume 0, Issue ja, -Not available-.
Source: Annals of Neurology - October 8, 2018 Category: Neurology Authors: Saravanan S. Karuppagounder,
Lauren Alin,
Yingxin Chen,
David Brand,
Megan W. Bourassa,
Kristen Dietrich,
Cassandra M. Wilkinson,
Colby A. Nadeau,
Amit Kumar,
Steve Perry,
John T. Pinto,
Victor Darley ‐Usmar,
Stephanie Sanchez,
Ginger L. Mi Source Type: research
Intravenous Thrombolysis for Ischemic Stroke Patients on Dual Antiplatelets
Annals of Neurology, EarlyView.
Source: Annals of Neurology - July 30, 2018 Category: Neurology Authors: Georgios
Tsivgoulis
MD
,
Aristeidis H.
Katsanos
MD
,
Dimitris
Mavridis
PhD
,
Zuzana
Gdovinova
MD
,
Micha ł
Karliński
MD
,
Mary Joan
Macleod
MD
,
Daniel
Strbian
MD
,
Niaz
Ahmed
MD Source Type: research
