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VIP and PACAP: Neuropeptide modulators of CNS inflammation, injury, and repair
Summary page Inflammatory processes play both regenerative and destructive roles in multiple sclerosis, stroke, CNS trauma, amyotrophic lateral sclerosis (ALS) and aging‐related neurodegenerative diseases such as Alzheimer's, Parkinson's, and Huntington's. Endogenous defense mechanisms against these pathologies include those that are directly neuroprotective, and those that modulate the expression of inflammatory mediators in microglia, astrocytes, and invading inflammatory cells. While a number of mechanisms and molecules have been identified that can directly promote neuronal survival, less is known about how the brain...
Source: British Journal of Pharmacology - March 20, 2013 Category: Drugs & Pharmacology Authors: J A Waschek Tags: Review Article Source Type: research

Opportunities for the repurposing of PARP inhibitors for the therapy of non ‐oncological diseases
We present a preclinical and clinical action plan for the repurposing of PARP inhibitors.
Source: British Journal of Pharmacology - March 26, 2017 Category: Drugs & Pharmacology Authors: Nathan A Berger, Valerie C Besson, A Hamid Boulares, Alexander B ürkle, Alberto Chiarugi, Robert S Clark, Nicola J Curtin, Salvatore Cuzzocrea, Ted M Dawson, Valina L Dawson, György Haskó, Lucas Liaudet, Flavio Moroni, Pál Pacher, Peter Radermacher, A Tags: REVIEW ARTICLE THEMED ISSUE Source Type: research