• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Characterization of a novel multi‐functional resveratrol derivative for the treatment of atrial fibrillation.
Conclusion and ImplicationsThese findings indicate that C1 is a promising multi‐functional small molecule that targets a number of key pathways involved in AF.
Source: British Journal of Pharmacology - September 17, 2013 Category: Drugs & Pharmacology Authors: Istvan Baczko, David Liknes, Wei Yang, Kevin C Hamming, Gavin Searle, Kristian Jaeger, Zoltan Husti, Viktor Juhasz, Gergely Klausz, Robert Pap, Laszlo Saghy, Andras Varro, Vernon Dolinsky, Shaohua Wang, Vivek Rauniyar, Dennis Hall, Jason R. Dyck, Peter E. Tags: Research Paper Source Type: research

Novel Analogues of Chlormethiazole are Neuroprotective in Four Cellular Models of Neurodegeneration by a Mechanism with Variable Dependence on GABAA Receptor Potentiation
Conclusions and ImplicationsThe results support the concept that CMZ does not contain a single pharmacophore, rather that broad‐spectrum neuroprotection results from a GABAA‐dependent mechanism represented by GN‐28, combined with a mechanism represented in GN‐38 that shows the least dependence on GABAA receptors. These findings allow further refinement of the neuroprotective pharmacophore and investigation into secondary mechanisms that will assist in identifying methiazole‐based compounds of use in treating neurodegeneration.
Source: British Journal of Pharmacology - October 10, 2013 Category: Drugs & Pharmacology Authors: Lawren VandeVrede, Ehsan Tavassoli, Jia Luo, Zhihui Qin, Lan Yue, David R. Pepperberg, Gregory R. Thatcher Tags: Research Paper Source Type: research

Characterization of a novel multifunctional resveratrol derivative for the treatment of atrial fibrillation
Conclusion and ImplicationsC1 behaved as a promising multifunctional small molecule targeting a number of key pathways involved in AF.
Source: British Journal of Pharmacology - December 10, 2013 Category: Drugs & Pharmacology Authors: Istvan Baczko, David Liknes, Wei Yang, Kevin C Hamming, Gavin Searle, Kristian Jaeger, Zoltan Husti, Viktor Juhasz, Gergely Klausz, Robert Pap, Laszlo Saghy, Andras Varro, Vernon Dolinsky, Shaohua Wang, Vivek Rauniyar, Dennis Hall, Jason RB Dyck, Peter E Tags: RESEARCH PAPER Source Type: research