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Impact of stroke misdiagnosis on short-term and discharge use of vascular medications in young adults (P7.125)
CONCLUSIONS: ED stroke misdiagnosis was associated with reduced use of early AT. At discharge, there was no variation in antithrombotic or statin use based on stroke misdiagnosis. Fewer than half of cryptogenic stroke patients received statins. Greater statin use in this population could reduce the rate of major vascular events Study Supported by: None Disclosure: Dr. Chaturvedi has received personal compensation for activities with Genentech, Inc., Abbott Vascular, Boehringer-Ingelheim, WL Gore, and Merck. Dr. Chaturvedi has received personal compensation in an editorial capacity for NEJM Jour...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Chaturvedi, S., Rajamani, K. Tags: Cerebrovascular Disease and Interventional Neurology: Stroke in Young Source Type: research

Atorvastatin Treatment Is Associated with Increased BDNF Level and Improved Functional Recovery after Atherothrombotic Stroke (S31.007)
Conclusions: Our results demonstrated that atorvastatin treatment was associated with increased BDNF level and improved functional recovery after atherothrombotic stroke. This study indicates that atorvastatin-related elevation in BDNF may promote functional recovery in stroke patients.Disclosure: Dr. Zhang has nothing to disclose. Dr. Mu has nothing to disclose. Dr. Gao has nothing to disclose. Dr. Huang has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Zhang, J., Mu, X., Gao, Z., Huang, Y. Tags: Stroke Risk, Outcomes, and Complications Source Type: research

Statin pretreatment is associated with better outcomes in large artery atherosclerotic stroke
Conclusion: Statin pretreatment in patients with acute LAA appears to be associated with better early outcomes regarding neurologic improvement, disability, survival, and stroke recurrence.
Source: Neurology - March 21, 2016 Category: Neurology Authors: Tsivgoulis, G., Katsanos, A. H., Sharma, V. K., Krogias, C., Mikulik, R., Vadikolias, K., Mijajlovic, M., Safouris, A., Zompola, C., Faissner, S., Weiss, V., Giannopoulos, S., Vasdekis, S., Boviatsis, E., Alexandrov, A. W., Voumvourakis, K., Alexandrov, A Tags: All Cerebrovascular disease/Stroke, Infarction ARTICLE Source Type: research

The Incidence Of Secondary Stroke Prevention Medication Following Hospitalization For Ischemic Stroke (I2-1.006)
CONCLUSIONS:The incidence of statins and ACE-I/ARB initiation following a stroke, among older adults discharged home was low (24-35%). Reported rates of side effects of either class of medications are not high enough to account for the low observed incidence. Better understanding of why beneficiaries are not receiving SSP, namely statins and ACE-I/ARBs, within 90 days of an ischemic stroke is critical to preventing recurrent stroke.Study Supported by:UnfundedDisclosure: Dr. Blackburn has nothing to disclose. Dr. Zhao has nothing to disclose. Dr. Kilgore has nothing to disclose. Dr. Albright has received research support fr...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Blackburn, J., Zhao, H., Kilgore, M., Albright, K. Tags: New Antithrombotic Agents for Stroke Prevention Poster Presentations Source Type: research

African Americans Are Less Likely to Be Adherent to Statins After Ischemic Stroke: An Analysis of Medicare Beneficiaries Following Hospital Discharge (I2.006)
Conclusions: African Americans may not be obtaining the recurrent stroke prevention therapy provided by statins, possibly contributing to the higher rate of recurrent stroke in this population.Disclosure: Dr. Albright has nothing to disclose. Dr. Blackburn has nothing to disclose. Dr. Zhao has nothing to disclose. Dr. Beasley has nothing to disclose. Dr. Limdi has nothing to disclose. Dr. Howard has nothing to disclose. Dr. Muntner has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Albright, K., Blackburn, J., Zhao, H., Beasley, T., Limdi, N., Howard, V., Muntner, P. Tags: Stroke in the Elderly and Young: Challenges for the Next Decade Data Blitz Presentations Source Type: research

COLADAS: Caribbean Origin Latin Americans Disparities in Acute Stroke (S4.002)
Conclusions: Our study reveals intrinsic sex differences that may imply under treatment. Understanding the reasons underlying these "sex-gaps" is critical. Study Supported By: Award Number Grants 5S21MD000242 and 5S21MD000138, from the National Center for Minority Health and Health Disparities, National Institutes of Health (NCMHD-NIH).Disclosure: Dr. Teron Molina has nothing to disclose. Dr. Rodríguez Centeno has nothing to disclose. Dr. Santiago has nothing to disclose. Dr. López Valentín has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Teron Molina, I., Rodriguez Centeno, A., Santiago, F., Lopez Valentin, M. Tags: Health Disparities and Sex Differences in Stroke Source Type: research

African Americans Are Less Likely to Be Adherent to Statins After Ischemic Stroke: An Analysis of Medicare Beneficiaries Following Hospital Discharge (S4.003)
Conclusions: African Americans may not be obtaining the recurrent stroke prevention therapy provided by statins, possibly contributing to the higher rate of recurrent stroke in this population.Disclosure: Dr. Albright has nothing to disclose. Dr. Blackburn has nothing to disclose. Dr. Zhao has nothing to disclose. Dr. Beasley has nothing to disclose. Dr. Limdi has nothing to disclose. Dr. Howard has nothing to disclose. Dr. Muntner has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Albright, K., Blackburn, J., Zhao, H., Beasley, T., Limdi, N., Howard, V., Muntner, P. Tags: Health Disparities and Sex Differences in Stroke Source Type: research

Statin therapy in acute ischemic stroke: Time for large randomized trials?
Despite improvements in stroke mortality coupled with therapeutic advances, stroke patients often face the prospect of substantial disability. Novel strategies are clearly needed to further improve stroke outcomes. These might include new indications for previously licensed drugs proven effective and safe in related disease processes,1 such as statins. Unlike strong evidence supporting statin use in cardiovascular risk reduction and acute myocardial ischemia, their effects on cerebral tissue and potential benefits on stroke outcomes remain poorly understood and understudied. The only current stroke-specific indication for ...
Source: Neurology - March 21, 2016 Category: Neurology Authors: Charidimou, A., Merwick, A. Tags: All Cerebrovascular disease/Stroke, Infarction EDITORIALS Source Type: research

The Effect Of Statin Pretreatment And Serum Lipid Values On Hemorragic Conversion After rt-PA for Acute Ischemic Stroke (P4.225)
CONCLUSIONS:Our study showed no significant correlation between PSS or lipid profile with ICH following IVT. Furthermore, no association with DmRS was found. Additional larger studies on PSS may be beneficial to determine the effects of statins on ICH risk.Disclosure: Dr. Khawaja has nothing to disclose. Dr. Lyerly has nothing to disclose. Dr. Kumar has nothing to disclose. Dr. Sands has nothing to disclose. Dr. Bavarsad Shahripour has nothing to disclose. Dr. Alexandrov has received personal compensation for activities with Genentech, Inc.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Khawaja, A., Lyerly, M., Kumar, G., Sands, K., Bavarsad Shahripour, R., Alexandrov, A. Tags: Cerebrovascular Disease and Interventional Neurology: Acute Stroke Thrombolysis Source Type: research

Executive function, but not memory, associates with incident coronary heart disease and stroke
Conclusion: Lower executive function, but not memory, is associated with higher risk of coronary heart disease and stroke. Lower executive function, as an independent risk indicator, might better reflect brain vascular pathologies.
Source: Neurology - August 31, 2015 Category: Neurology Authors: Rostamian, S., van Buchem, M. A., Westendorp, R. G. J., Jukema, J. W., Mooijaart, S. P., Sabayan, B., de Craen, A. J. M. Tags: All Cerebrovascular disease/Stroke, Cardiac, Cognitive aging, Cohort studies, Risk factors in epidemiology ARTICLE Source Type: research

Serum Albumin Is Associated with Cerebral Hemorrhage in Post-Intravenous Thrombolytic Therapy for Acute Stroke : A Retrospective Chart Review (P4.222)
CONCLUSION: Albumin may provide additional protection against hemorrhagic conversion after IV thrombolytic use in acute ischemic stroke. Study Supported by: noneDisclosure: Dr. Kamal has nothing to disclose. Dr. Li has nothing to disclose. Dr. Smith has nothing to disclose. Dr. Mustafa has nothing to disclose. Dr. Sawyer has nothing to disclose. Dr. Ching has nothing to disclose. Dr. Mehta has received personal compensation for activities with Biogen Idec, and Teva Neuroscience as a speaker, and with the Gerson Lehrman Group as a consultant.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Kamal, H., Li, P., Smith, K., Mustafa, G., Sawyer, R., Ching, M., Mehta, B. Tags: Cerebrovascular Disease and Interventional Neurology: Acute Stroke Thrombolysis Source Type: research

Meta-analysis of folic acid efficacy trials in stroke prevention: Insight into effect modifiers
Conclusions: Folic acid supplementation could reduce the stroke risk in regions without folic acid fortification, particularly in trials using a relatively low dosage of folic acid and with low vitamin B12 levels.
Source: Neurology - May 8, 2017 Category: Neurology Authors: Zhao, M., Wu, G., Li, Y., Wang, X., Hou, F. F., Xu, X., Qin, X., Cai, Y. Tags: Stroke prevention, All Cerebrovascular disease/Stroke, Clinical trials Randomized controlled (CONSORT agreement), All epidemiology ARTICLE Source Type: research

Racial differences in statin adherence following hospital discharge for ischemic stroke
Conclusions: Compared with white adults, black adults were more likely to be nonadherent to statins following hospitalization for ischemic stroke.
Source: Neurology - May 8, 2017 Category: Neurology Authors: Albright, K. C., Zhao, H., Blackburn, J., Limdi, N. A., Beasley, T. M., Howard, G., Bittner, V., Howard, V. J., Muntner, P. Tags: All Cerebrovascular disease/Stroke ARTICLE Source Type: research

Acute stroke chameleons in a university hospital: Risk factors, circumstances, and outcomes
Conclusions: AIS are missed in patients with younger age with a lower cerebrovascular risk profile and may be masked by other acute conditions. Patients with chameleons present more often with milder strokes or coma, fewer focal signs and cerebellar strokes, and have higher disability and mortality rates at 12 months. These findings may be used to raise awareness in emergency departments to recognize and treat such patients appropriately.
Source: Neurology - August 10, 2015 Category: Neurology Authors: Richoz, B., Hugli, O., Dami, F., Carron, P.-N., Faouzi, M., Michel, P. Tags: Other cerebrovascular disease/ Stroke, Natural history studies (prognosis), Risk factors in epidemiology, Infarction ARTICLE Source Type: research

HMG-CoA Reductase Inhibitor (Statin) Prescribing for Ischemic Stroke Patients at Hospital Discharge (P2.306)
Conclusions: Our observations suggest that neurologists may be more likely to prescribe a statin at the time of discharge for whites in group 3 (diabetics age 40-75 with LDL 70-189 without ASCVD) when compared to their black counterparts. Further research is needed to determine if racial disparities exist in discharge statin prescribing for stroke survivors.Disclosure: Dr. Albright has nothing to disclose. Dr. Vahidy has nothing to disclose. Dr. Sisson has nothing to disclose. Dr. Samai has nothing to disclose. Dr. Schluter has nothing to disclose. Dr. Martin-Schild has received personal compensation for activities with Genentech.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Albright, K., Vahidy, F., Moore, M., Samai, A., Schluter, L., Martin-Schild, S. Tags: Stroke Systems of Care Source Type: research

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