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Walking Quality During Inpatient Stroke Rehabilitation Assessed by Wireless Sensing (P5.176)
CONCLUSIONS: The laboratory-quality gait metrics calculated by our wireless sensor system were sensitive to functional improvements during a period of known clinical recovery. Commercial sensor systems, for which steps counts are inaccurate at the slow speeds typical of hemi-paretic walking, have difficulty producing outcomes related to motor control in persons disabled by neurologic disease. Measurement of the quantity and quality of movements performed during daily activities enables clinicians and researchers to supervise gait training and skills practice during rehabilitation.Disclosure: Dr. Dorsch has nothing to discl...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Dorsch, A., Thomas, S., Dobkin, B. Tags: Neuro-rehabilitation: Stroke Source Type: research

Comparison of the Checkerboard P300 Speller vs. the Row-Column Speller in Normal Elderly and an Aphasic Stroke Population (S21.006)
CONCLUSION: Our study demonstrates that stroke patients with Broca’s aphasia can use a P300 visual speller to communicate. Our results also indicate that in the elderly population, CBP is a superior paradigm compared to RCP. Disclosure: Dr. Shih has received research support from Eisai Inc., and Visualase Inc. Dr. Townsend has nothing to disclose. Dr. Krusienski has nothing to disclose. Dr. Shih has nothing to disclose. Dr. Shih has nothing to disclose. Dr. Heggeli has nothing to disclose. Dr. Paris has nothing to disclose. Dr. Meschia has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Shih, J., Townsend, G., Krusienski, D., Shih, K., Shih, R., Heggeli, K., Paris, T., Meschia, J. Tags: Neuro-rehabilitation and Neural Repair Source Type: research

Measuring Health-Related Quality Of Life (HRQOL) During Inpatient Stroke Rehabilitation (S21.002)
CONCLUSIONS: EQ-5 ratings converged between stroke survivors and clinicians, suggesting it is valid and reliable to measure moderate stroke survivor HRQOL in inpatient rehabilitation. EQ-5 and FIM improvement were poorly associated; HRQOL may independently complement functional outcome assessment in inpatient rehabilitation. Future studies could explore different areas of function to clarify the factor structure of improvement on these measures relative to HRQL.Study Supported by: NIH, Kessler FoundationDisclosure: Dr. Frisina has received personal compensation for activities with Kessler Institute for Rehabilitation as an...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Frisina, P., Kutlik, A., Hreha, K., Barrett, A. Tags: Neuro-rehabilitation and Neural Repair Source Type: research

Randomized Controlled Trial Of Constraint-Induced Aphasia Therapy In Patients With Chronic Stroke (S21.001)
Conclusions: Overall, this randomized controlled trial did not show improvement in language abilities in this small group of subjects with chronic post-stroke aphasia receiving CIAT when compared to observation.Disclosure: Dr. Szaflarski has received personal compensation for activities with UCB Pharma. Dr. Szaflarski has received research support from the National Institutes of Health, the American Academy of Neurology, the Shor Foundation for Epilepsy Research, Neuren, and Eisai Inc. Dr. Allendorfer has received research support from the Shor Foundation for Epilepsy Research. Dr. Ball has nothing to disclose. Dr. Banks h...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Szaflarski, J., Allendorfer, J., Ball, A., Banks, C., Dietz, A., Hart, K., Lindsell, C., Martin, A., Vannest, J. Tags: Neuro-rehabilitation and Neural Repair Source Type: research

Teaching NeuroImages: Abnormal cervical and cerebral vasculature in 22q11 deletion syndrome
A 12-day-old girl with a postnatal microarray diagnosis of 22q11.2 deletion syndrome was transferred for surgical repair of truncus arteriosus. Neurologic examination at the time of transfer was unremarkable. Brain MRI on day of life 9 demonstrated an absent left internal carotid flow void. Magnetic resonance angiography of the head (figure, A) and neck (figure, B) was subsequently obtained prior to cardiac repair. Patients with 22q11 deletion syndromes may have abnormal cervical vessel development.1 Children with congenital heart disease have an elevated stroke risk, particularly for periprocedural stroke.2 Understanding ...
Source: Neurology - July 3, 2017 Category: Neurology Authors: Mithal, D. S., Kurz, J. E. Tags: All Cerebrovascular disease/Stroke, Pediatric stroke; see Cerebrovascular Disease/ Childhood stroke, All Genetics RESIDENT AND FELLOW SECTION Source Type: research

Functional Motor Recovery In Stroke Survivors - Determinants In A Stroke Unit in Sub-Saharan Africa. (P3.045)
CONCLUSIONS:Frequent and effective visits to the physical therapist and to wit attainment of good and functional motor recovery may be hampered by its financial burden in resource poor settings where health insurance scarcely existStudy Supported by:NONEDisclosure: Dr. Imarhiagbe has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Imarhiagbe, F. Tags: Neural Repair and Neuro-rehabilitation: Clinical Source Type: research

White Matter Disease Ratings In Right Hemisphere Stroke (P3.052)
Conclusions: Our modified version of the Scheltens scale may provide a reliable rating method for quantifying WM diseases, especially using MR images. Although CT ratings were more agreeable, the inter-rater reliability on MR ratings was higher. This may be related to MR’s higher solution, which provides higher variety in scores for reliability analysis. This scoring method may help unravel the clinical significance of periventricular and deep WM disease.Disclosure: Dr. Bhat has nothing to disclose. Dr. Kim has nothing to disclose. Dr. Foundas has nothing to disclose. Dr. Chen has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Bhat, A., Kim, M., Foundas, A., Chen, P. Tags: Neural Repair and Neuro-rehabilitation: Clinical Source Type: research

Metabolomic analysis of PFO-related stroke shows immediate and persistent decrease of homocysteine post PFO closure (P2.277)
Conclusion We found PFO closure to lower HYC immediately in left atrial (arterial) blood, and this effect persists in peripheral venous circulation at 3 months post procedure. Since high level of HYC is independently associated with stroke and heart disease, our results suggest that mechanical PFO repair may improve circulatory profile of PFO stroke patients. Studies in a larger patient cohort and validation of other important metabolites are ongoing.Disclosure: Dr. Deng has nothing to disclose. Dr. Beecher has nothing to disclose. Dr. Burant has nothing to disclose. Dr. Lopez has nothing to disclose. Dr. De Jong has nothi...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Deng, W., Beecher, C., Burant, C., Lopez, M., De Jong, F., Palacios, I., Inglessis, I., Silverman, S., Feeney, K., Elia, M., Wickham, T., McMullin, D., Dec, G. W., Buonanno, F., Lo, E., Ning, M. Tags: Cerebrovascular Disease and Interventional Neurology: PFO and Other Cardiac Disease Source Type: research

Effect of Rehabilitation on Oligodendrocyte Progenitor Cells in a Mouse Model of White Matter Stroke (P5.224)
Conclusions: Rehabilitation with skilled reach after WMS in this mouse model potentiates two critical components of white matter repair: the number of OPCs, as well as their ability to mature. Disclosure: Dr. Borders has nothing to disclose. Dr. Ng has nothing to disclose. Dr. S. Thomas Carmichael has received personal compensation in an editorial capacity for Neurorehabiliation and Neural Repair.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Borders, C., Ng, K., Carmichael, S. Tags: Cerebrovascular Disease: Animal Models and In Vitro Models Source Type: research

Alterations In Muscle Coordination Following Robot-Assisted Gait Training In Hemiparetic Stroke: A Case Series (P3.047)
CONCLUSIONS: We conclude that RAGT may be associated with improvements in muscle coordination. Required next is a randomized control trial to investigate the efficacy of RAGT in improving rhythmic muscle coordination patterns in hemiparetic stroke. This evaluation method is a novel way to assess improvement in gait that goes beyond purely clinical evaluation.Study Supported by: HealthSouth CorporationDisclosure: Dr. Thrasher has nothing to disclose. Dr. Fisher has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Thrasher, A., Fisher, S. Tags: Neural Repair and Neuro-rehabilitation: Clinical Source Type: research

Electrical Stimulation of Neural Stem Cells Improves Stroke Recovery (P1.005)
Conclusions: Our results show that electrically preconditioned NSCs enhance stroke recovery. Gene expression of the thrombospondins (a family of matricellular proteins thought to be involved with angiogenesis and inflammation) and VEGF (proteins critical to angiogenesis) were found to be modified by electrically stimulating NSCs, suggesting possible mechanisms for functional recovery.Disclosure: Dr. George has nothing to disclose. Dr. Bliss has nothing to disclose. Dr. Mehta has nothing to disclose. Dr. Hua has nothing to disclose. Dr. Sun has nothing to disclose. Dr. Steinberg has received personal compensation for activi...
Source: Neurology - April 8, 2015 Category: Neurology Authors: George, P., Bliss, T., Mehta, S., Hua, T., Sun, G., Steinberg, G. Tags: Cerebrovascular Disease and Interventional Neurology Poster Discussion Session Source Type: research

Individualized Treatment With Transcranial Direct Current Stimulation In Patients With Chronic Nonfluent Aphasia Due To Stroke (S21.007)
CONCLUSIONS: Consistent with prior investigations, tDCS may be a promising technique for enhancing post-stroke aphasia recovery in a persistent manner. Optimal electrode arrangement appears to vary across participants, suggesting that individualized treatment may further improve language outcomes.Disclosure: Dr. Shah has nothing to disclose. Dr. Norise has nothing to disclose. Dr. Garcia has nothing to disclose. Dr. Torres has nothing to disclose. Dr. Faseyitan has nothing to disclose. Dr. Hamilton has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Shah, P., Norise, C., Garcia, G., Torres, J., Faseyitan, O., Hamilton, R. Tags: Neuro-rehabilitation and Neural Repair Source Type: research

Molecular medicine and the art of brain repair
Stroke, traumatic brain injury, and spinal cord injury claim patients in an instant from the ranks of the whole and independent and render them mentally or physically impaired. Once patients with acute diseases of the brain and nervous system are medically stabilized, they embark on neurorehabilitation, which reflects a medical past of longer admissions and deep personal interactions between staff and patients. Because neurorehabilitation stands apart from the trajectory of acute medical illness, its current practice remains a mystery for many physicians.In the book of shadows the first page is dark and the second darker s...
Source: Neurology - December 9, 2013 Category: Neurology Authors: Carmichael, S. T. Tags: All Clinical Neurology, All Cerebrovascular disease/Stroke, All Rehabilitation, Plasticity, Brain trauma REFLECTIONS: NEUROLOGY AND THE HUMANITIES Source Type: research

A Multicenter Phase II Randomized Trial of a HIF-Prolyl Hydroxylase Inhibitor for Neuroprotection in High Risk Thoracic Aortic Repair (S7.008)
Conclusions: Perioperative GSK1278863 was associated with more clinical events and SAEs but this is potentially confounded by imbalanced surgical risk in this small study. Overall, neurologic complications were common in this high risk population and additional studies of neuroprotection are needed.Disclosure: Dr. Messe has received personal compensation for activities with GlaxoSmithKline as a consultant. Dr. Messe has received research support from WL Gore and GlaxoSmithKline. Dr. Demopoulos has received personal compensation for activities with GlaxoSmithKline as an employer. Dr. Demopoulos holds stock in GlaxoSmithKlin...
Source: Neurology - April 3, 2016 Category: Neurology Authors: Messe, S., Demopoulos, L., Haws, T., Khonezhad, A., Leshnower, B., Coselli, J., Appoo, J., Hughes, G., Reece, T., Brinster, D., Kasner, S., Kern, J., Desai, N., Ballard, V., Fang, F., Lepore, J., Bavaria, J. Tags: Stroke Clinical Trials Source Type: research

Should TCDs be routinely used for evaluating intracranial circulation for screening high risk patients prior to cardiac surgery? (P2.280)
CONCLUSIONS: Our case elucidates the possibility of a hypoperfusion stroke related to left vertebral dominantly supplying intracranial circulation in presence of bilateral significant carotid stenosis. Due to lack of previous cardio/cerebrovascular events, his carotid stenosis was deemed asymptomatic prior to cardiac surgery. We propose that intracranial collateral flow should be investigated via TCD in patients with bilateral carotid stenosis undergoing procedures with high stroke risk to assess safety and efficacy of carotid revascularization in this small but significant subset. Additional studies like acetazolamide wit...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Vu, Q., Bishop, L., Edwards, M., Tegeler, C., Sarwal, A. Tags: Cerebrovascular Disease and Interventional Neurology: PFO and Other Cardiac Disease Source Type: research

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