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Prehospital stroke diagnostics based on neurological examination and transcranial ultrasound
Conclusions: The study demonstrates the feasibility and high diagnostic accuracy of emergency transcranial ultrasound assessment combined with neurological examinations for major ischemic stroke. Future combination with telemedical support, point-of-care analysis of blood serum markers, and probability algorithms of prehospital stroke diagnosis including ultrasound may help to speed up stroke treatment.
Source: BioMed Central - February 27, 2014 Category: Journals (General) Authors: Moriz HerzbergSandra BoyThilo HölscherMichael ErtlMarkus ZimmermannKarl-Peter IttnerJosef PemmerlHendrik PelsUlrich BogdahnFelix Schlachetzki Source Type: research

Timed up & go as a measure for longitudinal change in mobility after stroke - Postural Stroke Study in Gothenburg (POSTGOT)
The objectives were to investigate the distribution-based responsiveness of the Timed Up & Go (TUG) during the first three months after a first event of stroke, to measure the longitudinal change in TUG time during the first year after stroke and to establish whether recovery in TUG time differs between different age groups. Methods: Ninety-one patients with first-ever stroke were assessed using the Timed Up & Go at the 1st week and at 3, 6 and 12 months after stroke. The non-parametric sign-test, the parametric t-test and a mixed model approach to linear regression for repeated measurements (Proc mixed) were used for the ...
Source: BioMed Central - May 9, 2014 Category: Journals (General) Authors: Carina U PerssonAnna DanielssonKatharina S SunnerhagenAnna Grimby-EkmanPer-Olof Hansson Source Type: research

A pilot study of respiratory muscle training to improve cough effectiveness and reduce the incidence of pneumonia in acute stroke: study protocol for a randomized controlled trial
This study investigates a novel strategy based on an exercise intervention for cough rehabilitation.Trial registration: Current Controlled Trials ISRCTN40298220
Source: BioMed Central - April 12, 2014 Category: Journals (General) Authors: Stefan Tino KulnikGerrard Francis RaffertySurinder S BirringJohn MoxhamLalit Kalra Source Type: research

Development and psychometric evaluation of a new patient -reported outcome measure for stroke self -management: The Southampton Stroke Self - Management Questionnaire (SSSMQ)
Conclusions: Early findings suggest the Southampton Stroke Self-Management Questionnaire is a reliable and valid scale of self-management competency. The SSSMQ represents a potentially valid PROM for the evaluation of self-management following stroke.
Source: BioMed Central - October 3, 2015 Category: Journals (General) Authors: Emma J BogerMatthew HankinsSara H DemainSusan M Latter Source Type: research

Intensified secondary prevention intending a reduction of recurrent events in TIA and minor stroke patients (INSPiRE-TMS): a protocol for a randomised controlled trial
DiscussionGiven the high risk for vascular re-events in acute stroke and the available effective strategies in secondary prevention, the INSPIRE-TMS support program has the potential to lead to a relevant reduction of recurrent events. The trial will provide the basis for the decision whether an intensified secondary prevention program after stroke should be implemented into regular care. A cost-effectiveness evaluation will be performed.Trial registration: clinicaltrials.gov: 01586702.
Source: BioMed Central - January 24, 2013 Category: Journals (General) Authors: Stefanie LeistnerGeorg MichelsonInga LaumeierMichael AhmadiMaureen SmythGabriele NiewelerWolfram DoehnerJan SobeskyJochen B FiebachPeter MarxOtto BusseFriedrich KöhlerHolger PoppertMartin LJ WimmerThomas KnollPaul Von Weitzel-MudersbachHeinrich J Audeber Source Type: research

Parent and family impact of raising a child with perinatal stroke
Background: Perinatal stroke is a leading cause of early brain injury, cerebral palsy, and lifelong neurological morbidity. No study to date has examined the impact of raising a child with perinatal stroke on parents and families. However, a large breadth of research suggests that parents, and mothers in particular, may be at increased risk for psychological concerns. The primary aim of this study was to examine the impact of raising a child with perinatal stroke on mothers' wellbeing. A secondary aim was to examine how caring for a child with perinatal stroke differentially affects mothers and fathers. Methods: In Study I...
Source: BioMed Central - July 14, 2014 Category: Journals (General) Authors: Taryn B BemisterBrian L BrooksRichard H DyckAdam Kirton Source Type: research

An exploration of EEG features during recovery following stroke - implications for BCI-mediated neurorehabilitation therapy
Conclusions: This exploratory study illustrates that stroke and the accompanying neuroplastic changes associatedwith the recovery process can cause significant inter-subject changes in the EEG features suitable formapping as part of a neurofeedback therapy, even when individuals have scored largely similar withconventional behavioural measures. It appears such measures can mask this individual variability incortical reorganization. Consequently we believe motor retraining BCI should initially be tailored toindividual patients.
Source: BioMed Central - January 28, 2014 Category: Journals (General) Authors: Darren J LeamyJu¿ KocijanKatarina DomijanJoseph DuffinRichard AP RocheSean ComminsRónán CollinsTomas E Ward Source Type: research

The effect of obstructive sleep apnea and treatment with continuous positive airway pressure on stroke rehabilitation: rationale, design and methods of the TOROS study
This study will provide novel information on the effects of obstructive sleep apnea and its treatment with continuous positive airway pressure on rehabilitation outcomes after stroke.Trial registration: Trial registration number: Dutch Trial Register NTR3412.
Source: BioMed Central - February 25, 2014 Category: Journals (General) Authors: Justine A AaronsonCoen AM van BennekomWinni F HofmanTijs van BezeijJoost G van den AardwegErny GroetWytske A KylstraBen A Schmand Source Type: research

Rapamycin up-regulation of autophagy reduces infarct size and improves outcomes in both permanent MCAL, and embolic MCAO, murine models of stroke
Conclusions: While both inhibition and enhancement of autophagy by pharmacological intervention decreased lesion size and improved neurological scores, the enhancement with rapamycin showed a greater degree of improvement in outcomes as well as in survival. The protective action seen with chloroquine may be in part due to off-target effects on apoptosis separate from blocking lysosomal activity in autophagy.. We conclude pharmacologic induction of autophagy is more advantageous than its blockade in physiologically-relevant permanent and slow reperfusion stroke models.
Source: BioMed Central - June 21, 2014 Category: Journals (General) Authors: Kathleen M BuckleyDaniel L HessIrina Y SazonovaSudharsan Periyasamy-ThandavanJohn R BarrettRussell KirksHarrison GraceGalina KondrikovaMaribeth H JohnsonDavid C HessPatricia V SchoenleinMd Nasrul HodaWilliam D Hill Source Type: research

Mixed methods feasibility study for a trial of blood pressure telemonitoring for people who have had stroke/transient ischaemic attack (TIA)
Conclusions: A full-scale trial is feasible, likely to recruit well and have good rates of compliance and follow-up.Trial RegistrationISRCTN61528726 15/12/2011.
Source: BioMed Central - March 25, 2015 Category: Journals (General) Authors: Janet HanleyPeter FairbrotherAshma KrishanLucy McCloughanPaul PadfieldMary PatersonHilary PinnockAziz SheikhCathie SudlowAllison ToddBrian McKinstry Source Type: research

Is there association between hyperdense middle cerebral artery sign on CT scan and time from stroke onset within the first 24-hours?
Conclusions: No evidence of a correlation between time of stroke onset and presence of a HAS within the first 24-h post acute ischaemic stroke was identified. The HAS was associated with a higher NIHSS score at presentation.
Source: BioMed Central - July 2, 2015 Category: Journals (General) Authors: James HaridyLeonid ChurilovPeter MitchellRichard DowlingBernard Yan Source Type: research

Acceptance of disability and its predictors among stroke patients in Taiwan
Conclusions: The findings are beneficial to healthcare providers by identifying those stroke patients with predisposition of having lower disability acceptance, which could then facilitate the provision of appropriate rehabilitation interventions within six months after the diagnosis of stroke to support their adaptation process.
Source: BioMed Central - November 14, 2013 Category: Journals (General) Authors: Shan-Yun ChiuHanoch LivnehLong-Lung TsaoTzung-Yi Tsai Source Type: research

Observational Dutch Young Symptomatic StrokE studY (ODYSSEY): study rationale and protocol of a multicentre prospective cohort study
DiscussionODYSSEY is designed to prospectively determine prognosis after a young stroke and get more insight into etiology of patients with a TIA, ischemic stroke and intracerebral hemorrhage in patients aged 18 to 49 years old in a large sample size.
Source: BioMed Central - March 22, 2014 Category: Journals (General) Authors: Renate M ArntzMayte E van AlebeekNathalie E SynhaevePaul J BrouwersGert W van DijkRob A GonsTom den HeijerPaul LM de KortKarlijn F de LaatAnouk G van NordenSarah E VermeerMaureen J van der VlugtRoy PC KesselsEwoud J van DijkFrank-Erik de Leeuw Source Type: research

Effects of task-oriented robot training on arm function, activity, and quality of life in chronic stroke patients: a randomized controlled trial
Conclusion: Arm hand performance improved in chronic stroke patients, after eight weeks of task oriented training. The use of a Haptic Master robot in support of task-oriented arm training did not show additional value over the video-instructed task-oriented exercises in highly functional stroke patients.Clinical trial registration information: Current Controlled Trials ISRCTN82787126
Source: BioMed Central - March 31, 2014 Category: Journals (General) Authors: Annick AA TimmermansRyanne JM LemmensMaurice MonfranceRichard PJ GeersWilbert BakxRob JEM SmeetsHenk AM Seelen Source Type: research

Kinetic measurements of hand motor impairments after mild to moderate stroke using grip control tasks
Conclusions: This study designed a customized dynamometer together with an innovative measurement, RTR, to investigate the hand motor performance of subjects after mild to moderate stroke during force control tasks. And stroke-induced abnormal flexion synergy of wrist and finger muscles could be characterized by RTR. This study also identified a set of kinetic parameters which can be applied to quantitatively assess the hand motor function of subjects after mild to moderate stroke.
Source: BioMed Central - May 11, 2014 Category: Journals (General) Authors: Yu YeLe MaTiebin YanHuihua LiuXijun WeiRong Song Source Type: research

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