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Specialty: General Medicine
Source: LANCET
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Total 186 results found since Jan 2013.
Department of Error Department of Error
The AVERT Trial Collaboration group. Efficacy and safety of very early mobilisation within 24 h of stroke onset (AVERT): a randomised controlled trial. Lancet 2015; 386: 46–55—The column headings of figure 2 in the appendix of this Article have been changed from “OR [odds ratio]” to “ES [effect size]”. This correction has been made to the online version as of May 7, 2015, and the printed version is correct.
Source: LANCET - May 7, 2015 Category: Journals (General) Tags: Department of Error Source Type: research
Obituary Levi Watkins
Cardiac surgeon and US civil rights champion. Born in Parsons, KS, USA, on June 13, 1944, he died of complications from a stroke in Baltimore, MD, USA, on April 11, 2015, aged 70 years.
Source: LANCET - July 24, 2015 Category: Journals (General) Authors: Geoff Watts Tags: Obituary Source Type: research
Correspondence The promise of personalised medicine
I read with great interest the Viewpoint by Victor Dzau and colleagues (May 23, p 2118)1 who suggested that personalised and precision medicine would result in identification of patients at highest risk of six high-prevalence diseases (cancer, diabetes, heart disease, hypertension, lung disease, and stroke) and lead to subsequent early prophylactic intervention. The authors also suggested that personalised medicine could lead to substantial cumulative gains (expressed using US$100 000 per quality-adjusted life-year, with a $33 billion gain at a reduced disease incidence of 10% and up to a $607 billion gain at a 50% incid...
Source: LANCET - August 21, 2015 Category: Journals (General) Authors: Claude Matuchansky Tags: Correspondence Source Type: research
Comment Long working hours: an avoidable cause of stroke?
William Osler, in an article about atherosclerosis published 100 years ago, wrote that the main cause of myocardial infarction was “wear and tear of life”.1 Although we now have more detailed theories regarding the causal mechanisms, there is still some kinship between modern studies of work-related determinants of cardiovascular diseases and Osler's broad approach to the cause of disease.2
Source: LANCET - August 19, 2015 Category: Journals (General) Authors: Urban Janlert Tags: Comment Source Type: research
Correspondence Intracerebral haemorrhage, atrial fibrillation, and anticoagulation
The Review by Freek Verheugt and colleagues (July 18, p 303)1 provides an excellent overview of non-vitamin K antagonist oral anticoagulants (NOACs) and stroke prevention in atrial fibrillation. However, we emphasise another factor that was omitted: survivors of intracranial haemorrhage who also have atrial fibrillation. Observational studies show up to 37% of patients with an intracerebral haemorrhage have concurrent atrial fibrillation,2 with absolute numbers of patients who have anticoagulant-related intracranial haemorrhage expected to increase because of the increased use of oral anticoagulation and an ageing population.
Source: LANCET - October 30, 2015 Category: Journals (General) Authors: Duncan Wilson, Rustam Al-Shahi Salman, Catharina J M Klijn, Gregory Y H Lip, David J Werring Tags: Correspondence Source Type: research
Correspondence Intracerebral haemorrhage, atrial fibrillation, and anticoagulation – Authors' reply
We thank Duncan Wilson and colleagues for their comments about our Review.1 These authors discuss an important issue and suggest that non-vitamin K antagonist oral anticoagulants might provide a strong option to reduce ischaemic stroke in patients who have atrial fibrillation and have suffered an intracranial haemorrhage. A fundamental advantage of non-vitamin K antagonist oral anticoagulants over warfarin is the substantially lower risk of intracranial haemorrhage,2 and this feature might be particularly important for patients at high risk of intracranial haemorrhage, including those with previous history of this disorder.
Source: LANCET - October 30, 2015 Category: Journals (General) Authors: Freek W A Verheugt, Christopher B Granger Tags: Correspondence Source Type: research
World Report Profile: NIMHD—NIH's institute for minority health
For many Americans, health disparities are a fact of life—and death. Compared with white people, minorities are more likely to have and die from obesity, hypertension, heart attacks, cancer, stroke, and diabetes. On average, African-American people live 4 years less than do white people. The causes of these health disparities are a complex mixture of social and genetic factors, and they affect everything from the choices people make to how they interact with medical providers to how the system interacts with them.
Source: LANCET - November 6, 2015 Category: Journals (General) Authors: Carrie Arnold Tags: World Report Source Type: research
Articles Outcomes after thrombus aspiration for ST elevation myocardial infarction: 1-year follow-up of the prospective randomised TOTAL trial
Routine thrombus aspiration during PCI for STEMI did not reduce longer-term clinical outcomes and might be associated with an increase in stroke. As a result, thrombus aspiration can no longer be recommended as a routine strategy in STEMI.
Source: LANCET - October 13, 2015 Category: Journals (General) Authors: Sanjit S Jolly, John A Cairns, Salim Yusuf, Michael J Rokoss, Peggy Gao, Brandi Meeks, Sasko Kedev, Goran Stankovic, Raul Moreno, Anthony Gershlick, Saqib Chowdhary, Shahar Lavi, Kari Niemela, Ivo Bernat, Warren J Cantor, Asim N Cheema, Philippe Gabriel S Tags: Articles Source Type: research
Perspectives Consciousness: wonder and fragility
It was a Monday morning when he had a stroke. By that evening he'd had his second and possibly third. Life since has been a blur. We've been waiting for him to regain consciousness, each of us struggling to define what that means. At first it was simple: dead or alive, a drama played out in numbers on a computer screen above his head. As the signs of life get more familiar though, the question of consciousness becomes more complicated. “Wiggle your fingers if you can hear me.” “Can you open your eyes?” Each longed-for benchmark discarded as soon as it arrives, hopes immediately pinned to the next.
Source: LANCET - February 13, 2016 Category: Journals (General) Authors: Dara Mohammadi Tags: Perspectives Source Type: research
Articles Hydroxycarbamide versus chronic transfusion for maintenance of transcranial doppler flow velocities in children with sickle cell anaemia—TCD With Transfusions Changing to Hydroxyurea (TWiTCH): a multicentre, open-label, phase 3, non-inferiority trial
For high-risk children with sickle cell anaemia and abnormal TCD velocities who have received at least 1 year of transfusions, and have no MRA-defined severe vasculopathy, hydroxycarbamide treatment can substitute for chronic transfusions to maintain TCD velocities and help to prevent primary stroke.
Source: LANCET - December 6, 2015 Category: Journals (General) Authors: Russell E Ware, Barry R Davis, William H Schultz, R Clark Brown, Banu Aygun, Sharada Sarnaik, Isaac Odame, Beng Fuh, Alex George, William Owen, Lori Luchtman-Jones, Zora R Rogers, Lee Hilliard, Cynthia Gauger, Connie Piccone, Margaret T Lee, Janet L Kwiat Tags: Articles Source Type: research
Articles Blood pressure lowering for prevention of cardiovascular disease and death: a systematic review and meta-analysis
Blood pressure lowering significantly reduces vascular risk across various baseline blood pressure levels and comorbidities. Our results provide strong support for lowering blood pressure to systolic blood pressures less than 130 mm Hg and providing blood pressure lowering treatment to individuals with a history of cardiovascular disease, coronary heart disease, stroke, diabetes, heart failure, and chronic kidney disease.
Source: LANCET - December 23, 2015 Category: Journals (General) Authors: Dena Ettehad, Connor A Emdin, Amit Kiran, Simon G Anderson, Thomas Callender, Jonathan Emberson, John Chalmers, Anthony Rodgers, Kazem Rahimi Tags: Articles Source Type: research
Department of Error Department of Error
Howard G, Roubin GS, Jansen O, et al, on behalf of the Carotid Stenting Trialists' Collaboration. Association between age and risk of stroke or death from carotid endarterectomy and carotid stenting: a meta-analysis of pooled patient data from four randomised trials. Lancet 2016; 387: 1305–11—In the abstract of this Article, the first sentence of the interpretation section should read “In these RCTs, CEA was clearly superior to CAS in patients aged 70–74 years and older”. This correction has been made to the online version as of March 1, 2016.
Source: LANCET - February 29, 2016 Category: Journals (General) Tags: Department of Error Source Type: research
Obituary John Kurtzke
Pioneering neuroepidemiologist who studied multiple sclerosis. Born on Sept 14, 1926, in Brooklyn, NY, USA, he died from a stroke on Dec 1, 2015, in Falls Church, VA, USA, aged 89 years.
Source: LANCET - April 1, 2016 Category: Journals (General) Authors: Alison Snyder Tags: Obituary Source Type: research
Obituary Andrew Herxheimer
Clinical pharmacologist who founded Drug and Therapeutics Bulletin. Born in Berlin, Germany, on Nov 4, 1925, he died after a stroke in London, UK, on Feb 21, 2016, aged 90 years.
Source: LANCET - April 15, 2016 Category: Journals (General) Authors: Geoff Watts Tags: Obituary Source Type: research
