• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Occurrence and relative risk of stroke in incident and prevalent contemporary rheumatoid arthritis
Conclusion The magnitude of stroke risk is lower than for ischaemic heart disease in RA, and the evolvement of this risk from RA diagnosis may be slower. This suggests different driving forces behind these two RA co-morbidities and has implications for the clinical follow-up of patients with RA.
Source: Annals of the Rheumatic Diseases - February 25, 2013 Category: Rheumatology Authors: Holmqvist, M., Gransmark, E., Mantel, A., Alfredsson, L., Jacobsson, L. T. H., Wallberg-Jonsson, S., Askling, J. Tags: Immunology (including allergy), Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Rheumatoid arthritis Clinical and epidemiological research Source Type: research

Amelioration of experimental arthritis by stroke-induced immunosuppression is independent of Treg cell function
Conclusions MCAO ameliorates arthritis. The correlate of protection from arthritis is not the reduction of a particular pathogenic leucocyte subset or the preferential expansion or emergence of a protective cell population but the global reduction of leucocytes during arthritis.
Source: Annals of the Rheumatic Diseases - October 30, 2014 Category: Rheumatology Authors: Irmler, I. M., Gajda, M., Kamradt, T. Tags: Open access, Immunology (including allergy), Degenerative joint disease, Musculoskeletal syndromes Basic and translational research Source Type: research

Association of hyperlipidaemia, inflammation and serological status and coronary heart disease among patients with rheumatoid arthritis: data from the National Veterans Health Administration
Conclusions In this predominantly older male RA cohort, there was no clear association between LDL-C and CHD, whereas higher HDL-C was inversely associated with MI and stroke. CRP and ESR were similarly associated with increase MI risk and stroke, reflecting the prominent role of inflammation in CHD risk in RA.
Source: Annals of the Rheumatic Diseases - January 11, 2016 Category: Rheumatology Authors: Navarro-Millan, I., Yang, S., DuVall, S. L., Chen, L., Baddley, J., Cannon, G. W., Delzell, E. S., Zhang, J., Safford, M. M., Patkar, N. M., Mikuls, T. R., Singh, J. A., Curtis, J. R. Tags: Open access, Immunology (including allergy), Inflammation, Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Rheumatoid arthritis Clinical and epidemiological research Source Type: research

The risk of cardiovascular disease in systemic sclerosis: a population-based cohort study
Conclusions These findings provide the first general population-based evidence that SSc is associated with an increased risk of developing MI, stroke and PVD. Further insight into disease mechanisms, as well as how disease subtype, organ involvement and medication use may alter these increased risks, is needed.
Source: Annals of the Rheumatic Diseases - May 30, 2013 Category: Rheumatology Authors: Man, A., Zhu, Y., Zhang, Y., Dubreuil, M., Rho, Y. H., Peloquin, C., Simms, R. W., Choi, H. K. Tags: Connective tissue disease, Epidemiology Clinical and epidemiological research Source Type: research

The estimated frequency of antiphospholipid antibodies in young adults with cerebrovascular events: a systematic review
Background Around 10% of all thrombotic cerebrovascular events (CVE) occur in young population and in a large proportion of those the trigger remains undetermined. Antiphospholipid antibodies (aPL) are recognised risk factors for ischaemic stroke and recurrent thrombotic events; however, the frequency of aPL in young people with CVE is still an unresolved issue. Objectives To estimate the frequency of aPL in young adults with CVE and to determine whether aPL-positive young individuals are at greater risk of CVE when compared with individuals without aPL by systematically reviewing the literature. Methods Medline reports ...
Source: Annals of the Rheumatic Diseases - October 9, 2015 Category: Rheumatology Authors: Sciascia, S., Sanna, G., Khamashta, M. A., Cuadrado, M. J., Erkan, D., Andreoli, L., Bertolaccini, M. L., on behalf of APS Action Tags: Immunology (including allergy) Clinical and epidemiological research Source Type: research

Is ankylosing spondylitis a risk factor for cardiovascular disease, and how do these risks compare with those in rheumatoid arthritis?
Conclusions Prevalent patients with AS are at a 30%–50% increased risk of incident CV events. When compared with patients with RA, this level of increase was similar for stroke, but only half as high for ACS and thrombotic events.
Source: Annals of the Rheumatic Diseases - January 9, 2017 Category: Rheumatology Authors: Eriksson, J. K., Jacobsson, L., Bengtsson, K., Askling, J. Tags: Immunology (including allergy), Ankylosing spondylitis, Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Rheumatoid arthritis, Calcium and bone Clinical and epidemiological research Source Type: research

Long-term safety of rituximab in rheumatoid arthritis: 9.5-year follow-up of the global clinical trial programme with a focus on adverse events of interest in RA patients
Conclusions This analysis demonstrates that rituximab remains generally well tolerated over time and multiple courses, with a safety profile consistent with published data and clinical trial experience. Overall, the findings indicate that there was no evidence of an increased safety risk or increased reporting rates of any types of adverse events with prolonged exposure to rituximab during the 9.5 years of observation.
Source: Annals of the Rheumatic Diseases - August 6, 2013 Category: Rheumatology Authors: van Vollenhoven, R. F., Emery, P., Bingham, C. O., Keystone, E. C., Fleischmann, R. M., Furst, D. E., Tyson, N., Collinson, N., Lehane, P. B. Tags: Open access, Immunology (including allergy), Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Rheumatoid arthritis Clinical and epidemiological research Source Type: research

Prevalence of comorbidities in rheumatoid arthritis and evaluation of their monitoring: results of an international, cross-sectional study (COMORA)
Conclusions Among RA patients, there is a high prevalence of comorbidities and their risk factors. In this multinational sample, variability among countries was wide, not only in prevalence but also in compliance with recommendations for preventing and managing these comorbidities. Systematic measurement of vital signs and laboratory testing detects otherwise unrecognised comorbid conditions.
Source: Annals of the Rheumatic Diseases - December 4, 2013 Category: Rheumatology Authors: Dougados, M., Soubrier, M., Antunez, A., Balint, P., Balsa, A., Buch, M. H., Casado, G., Detert, J., El-zorkany, B., Emery, P., Hajjaj-Hassouni, N., Harigai, M., Luo, S.-F., Kurucz, R., Maciel, G., Mola, E. M., Montecucco, C. M., McInnes, I., Radner, H., Tags: Open access, Immunology (including allergy), Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Osteoporosis, Rheumatoid arthritis, Epidemiology, Calcium and bone Clinical and epidemiological research Source Type: research

The association between inflammatory markers, serum lipids and the risk of cardiovascular events in patients with rheumatoid arthritis
Conclusions This study provides evidence supporting the hypothesis that RA-related systemic inflammation plays a role in determining cardiovascular risk and a complex relationship between LDL and cardiovascular risk.
Source: Annals of the Rheumatic Diseases - June 6, 2014 Category: Rheumatology Authors: Zhang, J., Chen, L., Delzell, E., Muntner, P., Hillegass, W. B., Safford, M. M., Millan, I. Y. N., Crowson, C. S., Curtis, J. R. Tags: Editor's choice, Immunology (including allergy), Inflammation, Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Rheumatoid arthritis, Clinical diagnostic tests, Epidemiology Clinical and epidemiological research Source Type: research

Response to: 'Overweight/obesity and vitamin D deficiency contribute to the global burden of low back pain' by Professor Grant
We would like to thank William B Grant for his letter1 on our paper ‘The global burden of low back pain: estimates from the Global Burden of Disease 2010 study’.2 We fully agree with Professor Grant on the enormous potential that population-wide interventions have for reducing the global burden of low back pain. While more research is needed, the evidence base for several population-based interventions is already well established. For example, globally, and in low-income and middle-income countries in particular, population-based strategies that increase physical activity and reduce obesity are likely to have a...
Source: Annals of the Rheumatic Diseases - July 3, 2014 Category: Rheumatology Authors: Hoy, D., March, L., Brooks, P., Blyth, F., Woolf, A., Smith, E., Buchbinder, R. Tags: Electronic pages Source Type: research

Non-steroidal anti-inflammatory drugs and risk of cardiovascular disease in patients with rheumatoid arthritis: a nationwide cohort study
Conclusions The cardiovascular risk associated with NSAID use in RA patients was modest and significantly lower than in non-RA individuals. Moreover, only a few of the individual NSAIDs were associated with increased cardiovascular risk. NSAID use should be assessed in the individual patient based on the indication for pain relief and risk factors for adverse effects, and not automatically be avoided due to concerns of severe cardiovascular outcomes alone.
Source: Annals of the Rheumatic Diseases - July 3, 2014 Category: Rheumatology Authors: Lindhardsen, J., Gislason, G. H., Jacobsen, S., Ahlehoff, O., Olsen, A.-M. S., Ole Rintek Madsen, , Torp-Pedersen, C., Hansen, P. R. Tags: Immunology (including allergy), Biological agents, Connective tissue disease, Degenerative joint disease, Drugs: musculoskeletal and joint diseases, Musculoskeletal syndromes, Rheumatoid arthritis, Epidemiology Clinical and epidemiological research Source Type: research

Adverse outcomes after major surgery in patients with systemic lupus erythematosus: a nationwide population-based study
Conclusions SLE significantly increased the risks of surgical patients for overall major complications and mortality after major surgery. Our findings demonstrated the need for integrated care and revised protocols for perioperative management to improve outcomes for surgical patients with SLE.
Source: Annals of the Rheumatic Diseases - July 31, 2014 Category: Rheumatology Authors: Lin, J.-A., Liao, C.-C., Lee, Y.-J., Wu, C.-H., Huang, W.-Q., Chen, T.-L. Tags: Immunology (including allergy), Connective tissue disease, Systemic lupus erythematosus, Epidemiology Clinical and epidemiological research Source Type: research

Psoriasis, psoriatic arthritis and cardiovascular risk: are we closer to a clinical recommendation?
The issue of vascular risk in chronic arthropathies and especially the magnitude of such risk and its clinical implications in daily practice are of considerable current importance. Similarly, the relative risk across distinct arthropathies and other chronic inflammatory conditions is debated. Ogdie et al1 report associations between psoriasis, psoriatic arthritis (PsA), rheumatoid arthritis (RA) and an increased risk of major adverse cardiovascular events (MACE—myocardial infarction, stroke and cardiovascular death) in data derived from the UK primary care registry. Results are stratified by use of disease-modifying...
Source: Annals of the Rheumatic Diseases - January 7, 2015 Category: Rheumatology Authors: Kristensen, S. L., McInnes, I. B., Sattar, N. Tags: Immunology (including allergy), Inflammation, Biological agents, Connective tissue disease, Degenerative joint disease, Drugs: musculoskeletal and joint diseases, Musculoskeletal syndromes, Rheumatoid arthritis, Epidemiology Editorials Source Type: research

Disability and not osteoarthritis predicts cardiovascular disease: a prospective population-based cohort study
Conclusions In this large population-based study, participants with OA were not at increased risk of CVD. The close relation between disability and osteoarthritis may explain previous findings. Further studies are required in order to clarify whether OA patients need more intensive treatment of their cardiovascular risk factors.
Source: Annals of the Rheumatic Diseases - March 5, 2015 Category: Rheumatology Authors: Hoeven, T. A., Leening, M. J. G., Bindels, P. J., Castano-Betancourt, M., van Meurs, J. B., Franco, O. H., Kavousi, M., Hofman, A., Ikram, M. A., Witteman, J. C. M., Bierma-Zeinstra, S. M. Tags: Degenerative joint disease, Musculoskeletal syndromes, Osteoarthritis, Epidemiology Clinical and epidemiological research Source Type: research

Response to: 'Biologic agents for giant cell arteritis: treat to target by Moiseev et al
We thank Moiseev et al for their interest in our study of ustekinumab in giant cell arteritis (GCA).1 2 Our pilot study reported promising initial results from the use of ustekinumab in GCA.1 GCA is a potentially devastating disease with cranial ischaemic complications such as blindness and stroke occurring in 20%–25% of patients.3 While corticosteroids are effective in reducing the risk of cranial ischaemic complications, they do not fully extinguish the vascular inflammation in patients with GCA4–6 with consequent risk of disease relapse and longer-term consequences such as aortic aneurysms.7 8 Furthermore, c...
Source: Annals of the Rheumatic Diseases - August 9, 2016 Category: Rheumatology Authors: Conway, R., Molloy, E. S. Tags: Electronic pages Source Type: research

Pages: 1  2