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Coronary bypass surgery versus stenting in multivessel disease involving the proximal left anterior descending coronary artery
Conclusions In patients with multivessel disease with proximal LAD involvement, CABG is associated with lower rates of the safety composite endpoint of death, MI or stroke as compared with PCI with drug-eluting stents at 5 years of follow-up (number needed to treat=21). Trial registration number PRECOMBAT clinicaltrials.gov NCT00997828; SYNTAX: clinicaltrials.gov identifier: NCT00114972 NCT00114972.
Source: Heart - February 26, 2017 Category: Cardiology Authors: Cavalcante, R., Sotomi, Y., Zeng, Y., Lee, C. W., Ahn, J.-M., Collet, C., Tenekecioglu, E., Suwannasom, P., Onuma, Y., Park, S.-J., Serruys, P. W. Tags: Drugs: cardiovascular system, Interventional cardiology, Acute coronary syndromes, Percutaneous intervention, Epidemiology Coronary artery disease Source Type: research

Cardiovascular highlights from non-cardiology journals
Pre-operative aspirin does not influence CABG outcomes Aspirin is a common therapy for risk reduction among patients with coronary artery disease. However, among patients undergoing coronary artery bypass surgery, the benefits of aspirin on the risk of myocardial infarction and stroke may be outweighed by perioperative bleeding risk. To address this question, the ATACAS trial randomized 2100 patients to either receive 100 mg aspirin daily or matching placebo for 4 days immediately prior to the operation with all patients resuming aspirin within 24 hours of their bypass surgery. The primary outcome was a composite of d...
Source: Heart - June 5, 2016 Category: Cardiology Authors: Bradley, S. M. Tags: Journal scan Source Type: research

Bilateral internal mammary artery bypass grafting: long-term clinical benefits in a series of 1000 patients
Conclusions Our longitudinal analysis presents encouraging data concerning operative risk of BIMA grafting and provides excellent long-term survival in appropriately selected patients.
Source: Heart - May 13, 2013 Category: Cardiology Authors: Popovic, B., Voillot, D., Maureira, P., Vanhuyse, F., Agrinier, N., Aliot, E., Folliguet, T., Villemot, J. P. Tags: Drugs: cardiovascular system, Interventional cardiology, Acute coronary syndromes, Epidemiology Cardiovascular surgery Source Type: research

Sex differences in cardiovascular outcome during progression of aortic valve stenosis
Conclusions In the SEAS study, women and men had similar rates of AS progression and AS-related events. However, women had lower total mortality and ischaemic CV event rate than men independent of confounders. Trial registration number ClinicalTrials.gov identifier: NCT00092677.
Source: Heart - January 14, 2015 Category: Cardiology Authors: Cramariuc, D., Rogge, B. P., Lonnebakken, M. T., Boman, K., Bahlmann, E., Gohlke-Barwolf, C., Chambers, J. B., Pedersen, T. R., Gerdts, E. Tags: Open access, Drugs: cardiovascular system, Echocardiography, Hypertension, Interventional cardiology, Aortic valve disease, Clinical diagnostic tests, Epidemiology Valvular heart disease Source Type: research

Cost-effectiveness of percutaneous coronary intervention versus bypass surgery from a Dutch perspective
Conclusions For the broad population with three-vessel or left main disease who are candidates for either CABG or PCI, we found that CABG is a clinically and economically attractive revascularisation strategy compared with DES-PCI from a Dutch healthcare perspective. The cost-effectiveness of CABG versus PCI differed according to several anatomic factors, however. The newly developed SYNTAX Score II provides enhanced prognostic discrimination in this population, and may be a useful tool to guide resource allocation as well. Trial registration number Clinical trial unique identifier: NCT00114972 (http://www.clinical-trials.gov)
Source: Heart - November 26, 2015 Category: Cardiology Authors: Osnabrugge, R. L., Magnuson, E. A., Serruys, P. W., Campos, C. M., Wang, K., van Klaveren, D., Farooq, V., Abdallah, M. S., Li, H., Vilain, K. A., Steyerberg, E. W., Morice, M.-C., Dawkins, K. D., Mohr, F. W., Kappetein, A. P., Cohen, D. J., on behalf of Tags: Health policy, Drugs: cardiovascular system, Interventional cardiology, Acute coronary syndromes, Percutaneous intervention, Epidemiology Coronary artery disease Source Type: research

Ticagrelor and aspirin for the prevention of cardiovascular events after coronary artery bypass graft surgery
Conclusions Ticagrelor added to aspirin after CABG reduced the proportion of patients with graft occlusion, and was a significant univariate and multivariable predictor of graft occlusion. These results are hypothesis-generating and should be confirmed in larger studies. Trial registration number NCT01373411: Results.
Source: Heart - April 24, 2016 Category: Cardiology Authors: Saw, J., Wong, G. C., Mayo, J., Bernstein, V., Mancini, G. B. J., Ye, J., Skarsgard, P., Starovoytov, A., Cairns, J. Tags: Drugs: cardiovascular system, Interventional cardiology, Acute coronary syndromes, Clinical diagnostic tests, Epidemiology Coronary artery disease Source Type: research