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Specialty: Cardiology
Source: Heart

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Total 262 results found since Jan 2013.

Preserved stroke volume late after tetralogy repair, despite severe right ventricular dilatation
To the Editor Right ventricular (RV) enlargement due to increased pulmonary regurgitation has been identified as a significant issue in patients after repair of tetralogy of Fallot. In a recent study, O'Meagher et al1 reported an interesting observation; exercise capacity and stroke volume are maintained with RV end-diastolic volume index (RVEDVi) above, as opposed to below, a commonly used cut-off (150 mL/m2 of RVEDVi) for pulmonary valve replacement (PVR) surgery. They go on to conclude that the optimal timing for PVR remains unclear.1 We agree with their conclusion because the evidence provided by currently availab...
Source: Heart - November 20, 2013 Category: Cardiology Authors: Masutani, S., Senzaki, H. Tags: PostScript Source Type: research

Right ventricular stroke work in children with pulmonary arterial hypertension: a promising approach
To the Editor, We read with great interest the article by Di Maria et al,1 describing the importance of RV performance, especially RV stroke work (RVSW), in children with pulmonary arterial hypertension (PAH). The authors investigated the relation between echocardiographic measurements of RV function and the ‘gold standard’ of right heart catheterisation in children and found that RVSW strongly correlates with non-invasive data of RV function.1 The authors concluded that RVSW correlates with outcome parameters, for example, abnormal WHO class, and mortality, in children with PAH. We completely agree with the fi...
Source: Heart - August 6, 2014 Category: Cardiology Authors: Pansy, J., Koestenberger, M. Tags: PostScript Source Type: research

Loneliness and social isolation and increased risk of coronary heart disease and stroke: clinical implications
To the Editor The recent meta-analysis published in Heart by Valtorta et al1 showed that loneliness and social isolation are associated with increased incidence of coronary heart disease (CHD) and stroke in 16 large longitudinal studies conducted in high-income countries. This finding is not surprising given the extensive literature documenting such harmful consequences of social isolation, including a study my research group published in 19922 showing in a large sample of CHD patients that those who were not married and did not have a confident—and hence likely to be lonely and socially isolated—had a 5-year m...
Source: Heart - November 24, 2016 Category: Cardiology Authors: Williams, R. B. Tags: PostScript Source Type: research

Current and new oral antithrombotics in non-valvular atrial fibrillation: a network meta-analysis of 79 808 patients
Conclusions In this network meta-analysis, novel oral anticoagulants were the most promising treatments to reduce stroke, stroke or systemic embolism, and all-cause mortality in patients with AF.
Source: Heart - February 10, 2014 Category: Cardiology Authors: Dogliotti, A., Paolasso, E., Giugliano, R. P. Tags: Drugs: cardiovascular system, Epidemiology Arrhythmias and sudden death Source Type: research

Efficacy and safety of left atrial appendage closure versus medical treatment in atrial fibrillation: a network meta-analysis from randomised trials
Conclusions The findings of this meta-analysis suggest that LAAC is superior to placebo and APT, and comparable to NOAC for preventing mortality and stroke or SE, with similar bleeding risk in patients with non-valvular AF. However, these results should be interpreted with caution and more studies are needed to further substantiate this advantage, in view of the wide CIs with some variables in the current meta-analysis.
Source: Heart - January 4, 2017 Category: Cardiology Authors: Sahay, S., Nombela-Franco, L., Rodes-Cabau, J., Jimenez-Quevedo, P., Salinas, P., Biagioni, C., Nunez-Gil, I., Gonzalo, N., de Agustin, J. A., del Trigo, M., Perez de Isla, L., Fernandez-Ortiz, A., Escaned, J., Macaya, C. Tags: Editor's choice, Drugs: cardiovascular system, Epidemiology Arrhythmias and sudden death Source Type: research

Why should we screen for atrial fibrillation?
Atrial fibrillation (AF) constitutes an increasing challenge to the medical community and healthcare providers. With a prevalence of almost 3% in the adult Swedish population1 and a forecasted twofold or threefold increase by 2050 in the USA, we are facing a diagnosis with epidemic proportions. Apart from increased mortality, AF also increases the risk of heart failure, hospitalisations and ischaemic stroke.2 Of these complications, ischaemic stroke gives a particularly heavy burden on patients, their family and society. Ischaemic stroke is the most common reason for permanent neurological disability in the adult Western p...
Source: Heart - December 8, 2016 Category: Cardiology Authors: Svennberg, E., Engdahl, J. Tags: Press releases, Drugs: cardiovascular system, Epidemiology Editorials Source Type: research

Dipeptidyl peptidase-4 inhibitors and cardiovascular risks in patients with pre-existing heart failure
Conclusions In this nationwide T2DM cohort, the risks of mortality and the combination of MI and ischaemic stroke were lower for patients receiving DPP-4 inhibitors than for those who did not receive such treatment. DPP-4 inhibitor use was not associated with a higher risk of hospitalisation for HF even in patients with pre-existing HF.
Source: Heart - February 26, 2017 Category: Cardiology Authors: Ou, S.-M., Chen, H.-T., Kuo, S.-C., Chen, T.-J., Shih, C.-J., Chen, Y.-T. Tags: Health policy, Drugs: cardiovascular system, Acute coronary syndromes, Epidemiology, Diabetes, Metabolic disorders Heart failure and cardiomyopathies Source Type: research

Elective ascending aortic aneurysm repair outcomes in a nationwide US cohort
Conclusions The overall rate of in-hospital death, stroke and MI is nearly 5% in patients undergoing elective ascending aortic aneurysm repair. Among several predictors, chronic weight loss is associated with the largest increase in the risk of poor outcomes. Higher hospital volume is associated with a lower in-hospital mortality, highlighting the importance to refer patients to high-volume centres while discussing the risks and benefits of proceeding with repair.
Source: Heart - June 26, 2023 Category: Cardiology Authors: Beyer, S. E., Secemsky, E. A., Khabbaz, K., Carroll, B. J. Tags: Aortic and vascular disease Source Type: research

Blood pressure targets in patients with coronary artery disease: observations from traditional and Bayesian random effects meta-analysis of randomised trials
Conclusions The present body of evidence suggests that in patients with CAD, intensive systolic BP control to ≤135 mm Hg and possibly to ≤130 mm Hg is associated with a modest reduction in stroke and heart failure but at the expense of hypotension. Lower was better, although not consistently so for myocardial infarction, stroke, heart failure and perhaps angina. Further trials are needed to prove these findings.
Source: Heart - April 5, 2013 Category: Cardiology Authors: Bangalore, S., Kumar, S., Volodarskiy, A., Messerli, F. H. Tags: Drugs: cardiovascular system, Hypertension, Acute coronary syndromes, Stable coronary heart disease, Epidemiology Systematic review Source Type: research

Aspirin versus vitamin K antagonist treatment guided by transoesophageal echocardiography in patients with atrial fibrillation: a pilot study
Conclusions This hypothesis-generating pilot trial has found that TEE may be used for refinement of stroke risk in paroxysmal atrial fibrillation patients. A larger trial is needed to confirm these data. (ClinicalTrials.gov number NTC00224757).
Source: Heart - March 5, 2014 Category: Cardiology Authors: Dinh, T., Baur, L. H. B., Pisters, R., Kamp, O., Verheugt, F. W. A., Smeets, J. L. R. M., Cheriex, E. C., Lindeboom, J.-E., Heesen, W. F., Tieleman, R. G., Prins, M. H., Crijns, H. J. G. M., for the TIARA investigators, Dinh, Pisters, Tieleman, Prins, Cri Tags: Drugs: cardiovascular system, Echocardiography, Clinical diagnostic tests, Epidemiology Cardiac risk factors and prevention Source Type: research

Heartbeat: Focus on atrial fibrillation
Atrial fibrillation is very common; the estimated prevalence increases with age from about 0.1% in adults under age 55 years to 9% of those 80 years of age or older. AF is associated with a reduced quality of life due to the irregular heart rate and reduction in cardiac output. More importantly, AF is associated with an increased risk of thromboembolic events, with an annual stroke risk ranging from as low as <1% in patients with isolated AF to as high as 12% depending on additive risk factors including age over 75 years, female sex, diabetes, hypertension, heart failure, vascular disease or a prior stroke. Stroke risk ...
Source: Heart - May 12, 2015 Category: Cardiology Authors: Otto, C. M. Tags: Congenital heart disease, Drugs: cardiovascular system, Echocardiography, Hypertension, Clinical diagnostic tests, Epidemiology Heartbeat Source Type: research

Two-year clinical outcome from the Iberian registry patients after left atrial appendage closure
Conclusions LAA closure with an occlusion device in patients contraindicated for oral anticoagulants is a therapeutic option associated with fewer thromboembolic and haemorrhagic events than expected from risk scores, particularly in the second year postimplantation.
Source: Heart - May 12, 2015 Category: Cardiology Authors: Minguez, J. R. L., Asensio, J. M. N., Gragera, J. E., Costa, M., Gonzalez, I. C., de Carlos, F. G., Diaz, J. A. F., Yuste, V. M., Gonzalez, R. M., Dominguez-Franco, A., Buendia, A. B., Garibi, J. H., Hernandez, F. H., Ribeiro, V. G. Tags: Congenital heart disease in adult patients, Editor's choice, Drugs: cardiovascular system, Heart failure, Hypertension, Epidemiology Arrhythmias and sudden death Source Type: research

Biomarkers of inflammation and risk of cardiovascular events in anticoagulated patients with atrial fibrillation
Conclusions In patients with AF on anticoagulation, after accounting for clinical risk factors and other biomarkers, biomarkers of inflammation were significantly associated with an increased risk of mortality. However, there were no associations with the risk of stroke or major bleeding. Trial registration number ClinicalTrials.gov identifier: NCT00412984 post-results.
Source: Heart - March 11, 2016 Category: Cardiology Authors: Hijazi, Z., Aulin, J., Andersson, U., Alexander, J. H., Gersh, B., Granger, C. B., Hanna, M., Horowitz, J., Hylek, E. M., Lopes, R. D., Siegbahn, A., Wallentin, L., on behalf of the ARISTOTLE Investigators Tags: Editor's choice, Drugs: cardiovascular system, Acute coronary syndromes, Epidemiology Arrhythmias and sudden death Source Type: research

Outcomes and drivers of inappropriate dosing of non-vitamin K antagonist oral anticoagulants (NOACs) in patients with atrial fibrillation: a systematic review and meta-analysis
Conclusions Our analysis suggests that off-label underdosing of NOACs does not reduce bleeding outcomes. Patients prescribed off-label NOAC doses are at an increased risk of all-cause mortality. These data underscore the importance of prescriber adherence to NOAC dosing guidelines to achieve optimal clinical outcomes for patients with AF. PROSPERO registration number CRD42020219844.
Source: Heart - January 11, 2023 Category: Cardiology Authors: Caso, V., de Groot, J. R., Sanmartin Fernandez, M., Segura, T., Blomström-Lundqvist, C., Hargroves, D., Antoniou, S., Williams, H., Worsley, A., Harris, J., Caleyachetty, A., Vardar, B., Field, P., Ruff, C. T. Tags: Open access Systematic review Source Type: research

Trends in cardiovascular mortality and hospitalisations, and potential contribution of inhospital case-fatality rates to changes in national mortality in the Czech Republic 1994-2009
Conclusions During the study period, the overall CVD hospitalisation rates remained high but inhospital CFR declined considerably. The improved case-fatality seems to have made a substantial contribution to the decline in the national CVD mortality, particularly for AMI and stroke.
Source: Heart - February 18, 2013 Category: Cardiology Authors: Davidkovova, H., Kysely, J., Kriz, B., Vojtisek, P., Bobak, M. Tags: Health policy, Drugs: cardiovascular system, Hypertension, Acute coronary syndromes, Stable coronary heart disease, Epidemiology Source Type: research