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Source: Heart

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Total 262 results found since Jan 2013.

Exercise oxygen pulse kinetics in patients with hypertrophic cardiomyopathy
Conclusion None of the frequently used CPET parameters, either as absolute values or dynamic relationships, were associated with LVOTO. Differently, an abnormal temporal behaviour of O2-pulse during exercise, which is strongly related to inadequate SV increase, correlates with reduced functional capacity (peak and anaerobic threshold VO2 and workload) and increased VE/VCO2 slope, identifying more advanced disease irrespectively of LVOTO.
Source: Heart - September 26, 2022 Category: Cardiology Authors: Mapelli, M., Romani, S., Magri, D., Merlo, M., Cittar, M., Mase, M., Muratori, M., Gallo, G., Sclafani, M., Carriere, C., Zaffalon, D., Salvioni, E., Mattavelli, I., Vignati, C., De Martino, F., Rovai, S., Autore, C., Sinagra, G., Agostoni, P. Tags: Heart failure and cardiomyopathies Source Type: research

Contemporary demographics, diagnostics and outcomes in non-bacterial thrombotic endocarditis
Conclusions NBTE was more prevalent in females and embolic complications were the most frequent clinical finding. Overall, patients with NBTE had a poor prognosis, particularly in those with lung cancer or metastatic tumours. Further studies in patients with NBTE are needed given its morbidity and mortality.
Source: Heart - September 26, 2022 Category: Cardiology Authors: Quintero-Martinez, J. A., Hindy, J.-R., El Zein, S., Michelena, H. I., Nkomo, V. T., DeSimone, D. C., Baddour, L. M. Tags: Valvular heart disease, Editor's choice Source Type: research

Proteomics profiling reveals a distinct high-risk molecular subtype of hypertrophic cardiomyopathy
Conclusions Our prospective plasma proteomics study not only exhibited the presence of HCM molecular subtypes but also identified pathobiological mechanisms associated with a distinct high-risk subtype of HCM.
Source: Heart - October 28, 2022 Category: Cardiology Authors: Liang, L. W., Raita, Y., Hasegawa, K., Fifer, M. A., Maurer, M. S., Reilly, M. P., Shimada, Y. J. Tags: Heart failure and cardiomyopathies Source Type: research

Transcatheter versus surgical closure of atrial septal defect in adult patients with tricuspid regurgitation
Conclusions While TAP was effective for the treatment of significant TR, transcatheter ASD closure also significantly reduced TR as well. Transcatheter ASD closure may be considered an alternative treatment option in patients with moderate or severe TR.
Source: Heart - November 24, 2022 Category: Cardiology Authors: Kim, M., Lee, P. H., Kim, D.-H., Jung, S.-H., Lee, S.-A., Lee, S., Kang, D.-H., Song, J.-K., Song, J.-M. Tags: Congenital heart disease Source Type: research

Heartbeat: hospitalisation for COVID-19 is associated with an increased risk of subsequent adverse cardiovascular events
In order to assess whether previous COVID-19 infection might be associated with a higher risk of subsequent adverse cardiovascular disease (CVD) events, Raisi-Estabragh and colleagues1 analysed incident CVD events in 17 871 UK Biobank cases with prospective follow-up from March 2020 to March 2021. Hospitalisation for COVID-19 was associated with an increased risk of several adverse CVD events, including myocardial infarction, stroke, heart failure, atrial fibrillation, venous thromboembolism and mortality (figure 1). Risk was highest in the first 30 days after infection, but remained higher than matched controls over an av...
Source: Heart - December 22, 2022 Category: Cardiology Authors: Otto, C. M. Tags: COVID-19 Highlights from this issue Source Type: research

Not to be sneezed at: cardiovascular disease after COVID-19 infection
COVID-19 has changed our way of life since it was first identified in December of 2019. While our understanding of the manifestations and outcomes of the immediate acute illness has improved, we are still learning about the medium to long-term impact of this diagnosis on patients’ health. For some time, it has been suggested that COVID-19 may be associated with incident cardiovascular events such as venous thromboembolism, stroke and myocardial infarction.1 However, the absolute risk of these events and whether an excess risk is present are challenging to determine without a contemporary reference population. This is...
Source: Heart - December 22, 2022 Category: Cardiology Authors: Bularga, A., Newby, D. E., Chapman, A. R. Tags: Press releases, COVID-19 Editorials Source Type: research

Prediction of incident atrial fibrillation with cardiac biomarkers and left atrial volumes
Conclusions In the general population, echocardiographic left atrial volumetric indices and NT-proBNP, but not cTnT and GDF-15, associate with prevalent atrial fibrillation and with risk of incident atrial fibrillation. cTnT and NT-proBNP provide incremental prognostic information to echocardiography.
Source: Heart - February 14, 2023 Category: Cardiology Authors: Lyngbakken, M. N., Ronningen, P. S., Solberg, M. G., Berge, T., Brynildsen, J., Aagaard, E. N., Kvisvik, B., Rosjo, H., Steine, K., Tveit, A., Omland, T. Tags: Arrhythmias and sudden death Source Type: research

Cryoballoon Pulmonary Vein Isolation as First-Line Treatment for Typical Atrial Flutter
Conclusion Cryoballoon PVI as first-line treatment for AFL is equally effective compared with standard CTI ablation for preventing recurrence of atrial arrhythmia and better at preventing new-onset AF. Trial registration number NCT03401099.
Source: Heart - February 14, 2023 Category: Cardiology Authors: Gupta, D., Ding, W. Y., Calvert, P., Williams, E., Das, M., Tovmassian, L., Tayebjee, M. H., Haywood, G., Martin, C. A., Rajappan, K., Bates, M. G. D., Temple, I. P., Reichlin, T., Chen, Z., Balasubramaniam, R. N., Ronayne, C., Clarkson, N., Morgan, M., B Tags: Arrhythmias and sudden death Source Type: research

Emergent readmission and long-term mortality risk after incident atrial fibrillation hospitalisation
Conclusion This study highlights the large burden of unplanned all-cause and cardiovascular-specific readmissions within 2 years after being hospitalised for incident AF and their associated adverse impact on mortality. Concomitant comorbidities are independently associated with unplanned hospitalisations and mortality, which supports integrated multidisciplinary management of comorbidities, along with AF-targeted treatments, to improve long-term outcomes in patients with AF.
Source: Heart - February 14, 2023 Category: Cardiology Authors: Weber, C., Hung, J., Hickling, S., Li, I., Murray, K., Briffa, T. Tags: Cardiac risk factors and prevention Source Type: research

Lower birth weight is linked to poorer cardiovascular health in middle-aged population-based adults
Conclusions Lower birth weight was associated with greater risk of incident MI and unhealthy LV phenotypes; effects were partially mediated through cardiometabolic disease and systemic inflammation. These findings support consideration of birth weight in risk prediction and highlight actionable areas for disease prevention.
Source: Heart - March 10, 2023 Category: Cardiology Authors: Raisi-Estabragh, Z., Cooper, J., Bethell, M. S., McCracken, C., Lewandowski, A. J., Leeson, P., Neubauer, S., Harvey, N. C., Petersen, S. E. Tags: Open access Cardiac risk factors and prevention Source Type: research

Prevalence, outcomes and costs of a contemporary, multinational population with heart failure
Conclusions We estimate that 1–2% of the contemporary adult population has HF. These individuals are at significant risk of adverse outcomes and associated costs, predominantly driven by hospitalisations for HF or CKD. There is considerable public health potential in understanding the contemporary burden of HF and the importance of optimising its management.
Source: Heart - March 10, 2023 Category: Cardiology Authors: Norhammar, A., Bodegard, J., Vanderheyden, M., Tangri, N., Karasik, A., Maggioni, A. P., Sveen, K. A., Taveira-Gomes, T., Botana, M., Hunziker, L., Thuresson, M., Banerjee, A., Sundström, J., Bollmann, A. Tags: Open access, Press releases Heart failure and cardiomyopathies Source Type: research

Proof of concept study on coronary microvascular function in low flow low gradient aortic stenosis
Conclusions CMD is more severe in patients with LFLGAS compared with NFHGAS and is associated with low-flow state, left atrial dysfunction and reduced cardiac performance.
Source: Heart - April 25, 2023 Category: Cardiology Authors: Scarsini, R., Pighi, M., Mainardi, A., Portolan, L., Springhetti, P., Mammone, C., Della Mora, F., Fanti, D., Tavella, D., Gottin, L., Bergamini, C., Benfari, G., Pesarini, G., Ribichini, F. L. Tags: Valvular heart disease Source Type: research

Impact of pre-existing left atrial appendage occluder on catheter ablation of atrial fibrillation
Conclusions This pioneer study first showed impacts of LAAO on LA substrate and PVI procedure.
Source: Heart - May 26, 2023 Category: Cardiology Authors: Chen, J.-J., Chiu, F.-C., Chang, S.-N., Cheng, H.-L., Huang, P.-s., Wu, C.-K., Wang, Y.-C., Hwang, J.-J., Tsai, C.-T. Tags: Arrhythmias and sudden death Source Type: research

Heartbeat: prediction of atrial fibrillation risk
One of the challenges in prevention of stroke is identification of patients at risk of atrial fibrillation (AF) shortly before the onset of the arrhythmia so that prevention therapies can be promptly instituted. In this issue of Heart, Nadarajah and colleagues1 report the development and validation of an algorithm based on data from the UK Clinical Practice Research Datalink GOLD dataset that included 2 081 139 individuals of whom 7386 developed AF within 6 months. This new algorithm-- Future Innovations in Novel Detection of Atrial Fibrillation (FIND-AF) – identified a high-risk cohort with a 20-fold higher 6 month ...
Source: Heart - June 26, 2023 Category: Cardiology Authors: Otto, C. M. Tags: Highlights from this issue Source Type: research

Patient with altered mental status
Clinical introduction A woman in her 60s with history of diabetes mellitus, hypertension and hypothyroidism presented to the emergency department after being found confused, non-verbal and with low urine output in a nursing home. Her last known well was around 6 o’clock in the morning before presentation. Her temperature was 94.5°F, blood pressure (BP) was 179/80 mm Hg, heart rate (HR) was 50/min, and saturation was 97% on room air. She was cold to touch. The lungs were clear to auscultation bilaterally. She was noted to have gaze preference initially to the right, then to the left, right-sided weakness and left ...
Source: Heart - June 26, 2023 Category: Cardiology Authors: Khan, I., Atoot, A. Tags: Open access, Image challenges Source Type: research