• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

In patients with intracerebral haemorrhage and concomitant atrial fibrillation, optimal timing of reinitiating anticoagulants may be 7-8 weeks after ICH
Commentary on: Pennlert J, et al. Optimal timing of anticoagulant treatment after intracerebral haemorrhage in patients with atrial fibrillation. Stroke 2017:48;314–320. Context In patients with intracerebral haemorrhage (ICH) and a concomitant diagnosis of atrial fibrillation (AF), the clinical dilemma arises whether anticoagulant treatment should be (re)started and when.1 In the absence of results from randomised controlled trials, guidelines provide no firm recommendations. Several observational studies have suggested that reintroduction of oral anticoagulants may be associated with a reduction in thrombotic ...
Source: Evidence-Based Medicine - June 9, 2017 Category: Internal Medicine Authors: Klijn, C. J., Schreuder, F. H. Tags: Therapeutics/Prevention Source Type: research

Pitfalls of administrative database analysis are evident when assessing the 'weekend effect in stroke
Commentary on: Li L, Rothwell PM. Biases in detection of apparent "weekend effect" on outcome with administrative coding data: population based study of stroke. BMJ 2016;353:i2648 . Context Multiple studies attempt to clarify the role of weekend admissions in stroke.1 2 Recent studies have leveraged large populations in administrative databases to retrospectively evaluate hypotheses. While these studies disagree as to whether weekend admissions are associated with increased stroke mortality, concern exists regarding inherent limitations of administrative coding databases, including accuracy of patient and disease variables...
Source: Evidence-Based Medicine - January 23, 2017 Category: Internal Medicine Authors: Attenello, F. J., Mack, W. J. Tags: EBM Prognosis, Journalology, Epidemiologic studies, Stroke Source Type: research

Perioperative selective serotonin reuptake inhibitor administration is a marker of poor outcomes after surgery
Commentary on: Auerbach AD, Vittinghoff E, Maselli J, et al.. Perioperative use of selective serotonin reuptake inhibitors and risks for adverse outcomes of surgery. JAMA Intern Med 2013;173:1075–81. Context With a lifetime prevalence of 6–11%, depression is a common comorbidity in surgical patients. Owing to their high efficacy and safety, selective serotonin reuptake inhibitors (SSRIs) are the most commonly prescribed antidepressants.1 Some studies suggest that SSRIs may increase surgical bleeding. However, SSRI discontinuation may exacerbate psychiatric illness or precipitate withdrawal symptoms. Therefore, ...
Source: Evidence-Based Medicine - March 19, 2014 Category: Internal Medicine Authors: Holt, N. F. Tags: EBM Aetiology, Epidemiologic studies, Drugs: cardiovascular system, Drugs: CNS (not psychiatric), Heart failure, Stroke, Obesity (nutrition), Interventional cardiology, Drugs: musculoskeletal and joint diseases, Health education Source Type: research

Presence during cardiopulmonary resuscitation is beneficial to family members in the out-of-hospital setting
Commentary on: Jabre P, Belpomme V, Azoulay E, et al.. Family presence during cardiopulmonary resuscitation. N Engl J Med 2013;368:1008–18. Context Inviting family members to be present during cardiopulmonary resuscitation (CPR) is increasingly common; however, it is still a controversial practice and has not been widely adopted in the USA. While a number of studies suggest that family members are amenable to this practice, robust, scientifically rigorous evidence demonstrating the psychological impact of witnessing a family member's resuscitation is lacking. Methods A total of 570 first-degree, adult family members ...
Source: Evidence-Based Medicine - January 22, 2014 Category: Internal Medicine Authors: Compton, S., Fernandez, R. Tags: Epidemiologic studies, Stroke, Interventional cardiology, Anxiety disorders (including OCD and PTSD), Child and adolescent psychiatry, Legal and forensic medicine Therapeutics Source Type: research