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Specialty: Transplant Surgery
Source: Artificial Organs

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Total 32 results found since Jan 2013.

Three ‐Dimensional Numerical Simulations of Aspiration Process: Evaluation of Two Penumbra Aspiration Catheters Performance
AbstractAcute ischemic stroke (AIS) is the leading cause of mortality and disability worldwide. AIS occur while cerebral arteries become blocked by embolism or thrombosis. Aspiration thrombectomy is a promising interventional device to extract massive clots from occluded cerebral arteries. The aim of this article is to develop a computer ‐aided method to clarify the performance of aspiration catheter and identify the risks of aspiration for each specific AIS patient. In order to simulate the aspiration process, a three‐dimensional fluid‐structure interaction (FSI) method was developed. The blood clot was modeled as a...
Source: Artificial Organs - November 15, 2018 Category: Transplant Surgery Authors: Alireza Chitsaz, Amir Nejat, Reza Nouri Tags: Main Text Article Source Type: research

Synchronized Pulsatile Flow With Low Systolic Output From Veno ‐Arterial Extracorporeal Membrane Oxygenation Improves Myocardial Recovery After Experimental Cardiac Arrest in Pigs
Abstract Circulatory failure following cardiac arrest (CA) requires catecholamine support and occasionally veno‐arterial extracorporeal membrane oxygenation (vaECMO). VaECMO‐generated blood flow is continuous and retrograde, increasing ventricular stroke work. Our aim was to assess the benefit of a device generating a pulsatile vaECMO flow synchronized with the heart rhythm lowering systolic vaECMO output on the left ventricular ejection fraction (LVEF) and pulmonary capillary pressure (Pcap) after CA. This experimental randomized study in pigs compared standard nonpulsatile vaECMO (control) with pulsatile synchronized...
Source: Artificial Organs - March 6, 2018 Category: Transplant Surgery Authors: Sebastian Voicu, Georgios Sideris, Jean ‐Guillaume Dillinger, Demetris Yannopoulos, Nicolas Deye, Chantal Kang, Michel Bonneau, Jason Bartos, Antoni Kedra, Sophie Bailliart, Adrien Pasteur‐Rousseau, Guy Amah, Philippe Bonnin, Jacques Callebert, Patric Tags: Main Text Source Type: research

The Progress in the Novel Pediatric Rotary Blood Pump Sputnik Development
In this study, a mock circulatory system (MCS) allowing simulation of physiological cardiovascular characteristics was used to investigate the interaction of the Sputnik PRBP with the cardiovascular system. MCS allows reproducing the Frank‐Starling autoregulation mechanism of the heart. PRBP behavior was tested in the speed range of 6 000 to 15 000 rpm. Decreased contractility can be expressed in a stroke volume decrease approximately from 18 to 4 mL and ventricle systolic pressure decrease approximately from 92 to 20 mm Hg. The left ventricle becomes fully supported at a pump speed of 10 000 rpm. At a pump speed of 1...
Source: Artificial Organs - March 6, 2018 Category: Transplant Surgery Authors: Dmitry Telyshev, Maxim Denisov, Alexander Pugovkin, Sergey Selishchev, Igor Nesterenko Tags: Main Text Source Type: research

Type II Minimal ‐Invasive Extracorporeal Circuit for Aortic Valve Replacement: A Randomized Controlled Trial
Abstract Extracorporeal circulation triggers systemic inflammatory response and coagulation disorders which may lead to unfavorable clinical outcome. A type II minimally‐invasive extracorporeal circuit (MiECC) is a closed system with markedly reduced artificial surface as compared to conventional extracorporeal circuits (CECC). The aim of this study was to investigate and compare inflammatory responses, complement activation and selected clinical end‐points in isolated surgical aortic valve replacement (SAVR) performed with a type II MiECC circuit or a CECC. Fifty patients were prospectively randomized to MiECC or CECC...
Source: Artificial Organs - February 12, 2018 Category: Transplant Surgery Authors: Erich Gygax, Hans ‐Ulrich Kaeser, Mario Stalder, Brigitta Gahl, Robert Rieben, Thierry Carrel, Gabor Erdoes Tags: Main Text Source Type: research

Temporal and Spatial Variability of Surface Motor Activation Zones in Hemiplegic Patients During Functional Electrical Stimulation Therapy Sessions
Abstract The goal of this study was to investigate surface motor activation zones and their temporal variability using an advanced multi‐pad functional electrical stimulation system. With this system motor responses are elicited through concurrent activation of electrode matrix pads collectively termed “virtual electrodes” (VEs) with appropriate stimulation parameters. We observed VEs used to produce selective wrist, finger, and thumb extension movements in 20 therapy sessions of 12 hemiplegic stroke patients. The VEs which produce these three selective movements were created manually on the ergonomic multi‐pad ele...
Source: Artificial Organs - November 17, 2017 Category: Transplant Surgery Authors: Jovana Male šević, Matija Štrbac, Milica Isaković, Vladimir Kojić, Ljubica Konstantinović, Aleksandra Vidaković, Suzana Dedijer Dujović, Miloš Kostić, Thierry Keller Tags: Main Text Article Source Type: research

Brain ‐Computer Interfaces With Multi‐Sensory Feedback for Stroke Rehabilitation: A Case Study
Abstract Conventional therapies do not provide paralyzed patients with closed‐loop sensorimotor integration for motor rehabilitation. This work presents the recoveriX system, a hardware and software platform that combines a motor imagery (MI)‐based brain‐computer interface (BCI), functional electrical stimulation (FES), and visual feedback technologies for a complete sensorimotor closed‐loop therapy system for poststroke rehabilitation. The proposed system was tested on two chronic stroke patients in a clinical environment. The patients were instructed to imagine the movement of either the left or right hand in ran...
Source: Artificial Organs - November 17, 2017 Category: Transplant Surgery Authors: Danut C. Irimia, Woosang Cho, Rupert Ortner, Brendan Z. Allison, Bogdan E. Ignat, Guenter Edlinger, Christoph Guger Tags: Main Text Article Source Type: research

Experimental Investigation of Left Ventricular Flow Patterns After Percutaneous Edge ‐to‐Edge Mitral Valve Repair
Abstract Mitral valve percutaneous edge‐to‐edge repair (PEtER) is a viable solution in high‐risk patients with severe symptomatic mitral regurgitation. However, the generated double‐orifice configuration poses challenges for the evaluation of the hemodynamic performance of the mitral valve and may alter flow patterns in the left ventricle (LV) during diastole. This in vitro study aims to evaluate the hemodynamic modifications following a simulated PEtER. A custom‐made mitral valve was developed, and two configurations were tested: (i) a single‐orifice valve with mitral regurgitation and (ii) a double‐orifice ...
Source: Artificial Organs - November 1, 2017 Category: Transplant Surgery Authors: Morteza Jeyhani, Shahrokh Shahriari, Michel Labrosse Tags: Main Text Source Type: research

Remote Ischemic Preconditioning and Clinical Outcomes in On ‐Pump Coronary Artery Bypass Grafting: A Meta‐Analysis of 14 Randomized Controlled Trials
Abstract The purpose of this article is to perform the first pooled analysis on remote ischemic preconditioning (RIPC) used for the improvement of clinical outcomes of patients only undergoing on‐pump coronary artery bypass grafting (CABG) in randomized controlled trials (RCTs). A systematic search was performed using PubMed, the Cochrane Library, and the Web of Science to identify studies that described the effect of RIPC on postoperative mortality in patients only undergoing on‐pump CABG. The outcomes included postoperative mortality, postoperative morbidity (including incidence of myocardial infarction, atrial fibri...
Source: Artificial Organs - July 25, 2017 Category: Transplant Surgery Authors: Bin Yi, Jianhui Wang, Dingwu Yi, Yanling Zhu, Yumei Jiang, Yi Li, Shaoyan Mo, Yi Liu, Jian Rong Tags: Main Text Source Type: research

The Effect of Impella CP on Cardiopulmonary Physiology During Venoarterial Extracorporeal Membrane Oxygenation Support
Abstract Left ventricle (LV) distension is a complication of venoarterial extracorporeal membrane oxygenation (VA‐ECMO) support. The effects of Impella on the pulmonary circulatory physiology were studied in a single‐center study of six consecutive patients on VA‐ECMO support who had LV unloading with Impella. Right ventricular stroke volume, pulmonary hemodynamics, and partial pressure of end‐tidal CO2 (PETCO2) were measured on echocardiogram, pulmonary artery catheter, and capnography, respectively. The addition of Impella CP increased total blood flow and reduced pulmonary artery wedge pressure. There was a smal...
Source: Artificial Organs - June 1, 2017 Category: Transplant Surgery Authors: Hoong Sern Lim Tags: Main Text Source Type: research

SANGUINATE (PEGylated Carboxyhemoglobin Bovine): Mechanism of Action and Clinical Update
Abstract Historically, blood substitutes were under development that would provide oxygen carrying capacity as well as fluid replacement for both trauma and surgical indications. Their development was halted by the inability of the products to deliver therapeutic amounts of oxygen targeted to hypoxic tissue as well as from the inherent toxicity of the molecules. This led to the concept of an oxygen therapeutic that would be targeted for indications caused by anemia/ischemia/hypoxia but would not exhibit the toxicity that plagued earlier products. The complex pathophysiology of diseases such as sickle cell and hemorrhagic s...
Source: Artificial Organs - April 11, 2017 Category: Transplant Surgery Authors: Abraham Abuchowski Tags: Main Text Article Source Type: research

What Is the Optimal Setting for a Continuous ‐Flow Left Ventricular Assist Device in Severe Mitral Regurgitation?
In this study, we assessed the utility of our electrocardiogram‐synchronized rotational speed (RS) modulation system along with a continuous‐flow LVAD in a goat model of MR. We implanted EVAHEART devices after left thoracotomy in six adult goats weighing 66.4 ± 10.7 kg. Severe MR was induced through inflation of a temporary inferior vena cava filter placed within the mitral valve. We evaluated total flow (TF; the sum of aortic flow and pump flow [PF]), RV fractional area change (RVFAC) calculated by echocardiography, left atrial pressure (LAP), LV end‐diastolic pressure (LVEDP), LV end‐diastolic volume (LVEDV)...
Source: Artificial Organs - May 18, 2016 Category: Transplant Surgery Authors: Noritsugu Naito, Takashi Nishimura, Yoshiaki Takewa, Satoru Kishimoto, Kazuma Date, Akihide Umeki, Masahiko Ando, Minoru Ono, Eisuke Tatsumi Tags: Main Text Source Type: research

What Is the Optimal Setting for a Continuous‐Flow Left Ventricular Assist Device in Severe Mitral Regurgitation?
In this study, we assessed the utility of our electrocardiogram‐synchronized rotational speed (RS) modulation system along with a continuous‐flow LVAD in a goat model of MR. We implanted EVAHEART devices after left thoracotomy in six adult goats weighing 66.4 ± 10.7 kg. Severe MR was induced through inflation of a temporary inferior vena cava filter placed within the mitral valve. We evaluated total flow (TF; the sum of aortic flow and pump flow [PF]), RV fractional area change (RVFAC) calculated by echocardiography, left atrial pressure (LAP), LV end‐diastolic pressure (LVEDP), LV end‐diastolic volume (LVEDV)...
Source: Artificial Organs - April 30, 2016 Category: Transplant Surgery Authors: Noritsugu Naito, Takashi Nishimura, Yoshiaki Takewa, Satoru Kishimoto, Kazuma Date, Akihide Umeki, Masahiko Ando, Minoru Ono, Eisuke Tatsumi Tags: Main Text Source Type: research

Impact of Therapeutic Plasma Exchange on Hemodynamic Parameters in Medical Intensive Care Unit Patients: An Observational Study
Abstract Therapeutic plasma exchange (TPE) is an extracorporeal treatment with reported beneficial as well as detrimental effects on circulation. However, there is a lack of data using advanced hemodynamic monitoring during TPE. Therefore, we investigated the effects of TPE on hemodynamic parameters derived from transpulmonary thermodilution (TPTD) as well as the risk for transfusion‐related acute lung injury (TRALI). We compared hemodynamic parameters obtained before and after a total of 30 sessions of TPE treatment in 10 intensive care unit patients. Among standard hemodynamic parameters, heart rate (P < 0.012) ...
Source: Artificial Organs - March 31, 2016 Category: Transplant Surgery Authors: Tobias Lahmer, Marlena Messer, Christopher Schnappauf, Sebastian Rasch, Lisa Fekecs, Analena Beitz, Stefan Eser, Roland M. Schmid, Wolfgang Huber Tags: Thoughts and Progress Source Type: research

Are the Current Doppler Echocardiography Criteria Able to Discriminate Mitral Bileaflet Mechanical Heart Valve Malfunction? An In Vitro Study
Abstract Malfunction of bileaflet mechanical heart valves in the mitral position could either be due to patient–prosthesis mismatch (PPM) or leaflet obstruction. The aim of this article is to investigate the validity of current echocardiographic criteria used for diagnosis of mitral prosthesis malfunction, namely maximum velocity, mean transvalvular pressure gradient, effective orifice area, and Doppler velocity index. In vitro testing was performed on a double activation left heart duplicator. Both PPM and leaflet obstruction were investigated on a St. Jude Medical Master. PPM was studied by varying the St. Jude prosthe...
Source: Artificial Organs - January 27, 2016 Category: Transplant Surgery Authors: Morgane Evin, Carine Guivier‐Curien, Philippe Pibarot, Lyes Kadem, Régis Rieu Tags: Main Text Article Source Type: research

Effects of Interaction Between Ventricular Assist Device Assistance and Autoregulated Mock Circulation Including Frank–Starling Mechanism and Baroreflex
In this study, a preload sensitive MHCL, the MHCLAUTO, was developed to investigate the interaction between the left ventricle and left ventricular assist devices (LVADs). The Frank–Starling mechanism was modeled by regulating the stroke volume (SV) based on the measured mean diastolic left atrial pressure (MLAPdiast). The baroreflex autoregulation mechanism was implemented to maintain a constant mean aortic pressure (MAP) by varying ventricular contractility (Emax), heart rate (HR), afterload/systemic vascular resistance (SVR) and unstressed venous volume (UVV). The DP3 blood pump (Medos Medizintechnik GmbH) was used to...
Source: Artificial Organs - November 19, 2015 Category: Transplant Surgery Authors: So‐Hyun Jansen‐Park, Mohammad Nauzef Mahmood, Indra Müller, Lisa Kathrin Turnhoff, Thomas Schmitz‐Rode, Ulrich Steinseifer, Simon Johannes Sonntag Tags: Main Text Article Source Type: research