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Trends and Characteristics of Tuberculous Meningitis in the United States, 1993-2013 (S30.007)
Conclusions:Over the past two decades, the incidence and mortality of TBM in the US have steadily declined, but neurological complications are increasing.Study Supported by:This work was supported by the National Institute of Neurological Disorders [grant numbers K23NS082367, R01NS097443-01 to H.K.] and the Michael Goldberg Stroke Research Fund to [H.K.].Disclosure: Dr. Merkler has nothing to disclose. Dr. Chatterjee has nothing to disclose. Dr. Gialdini has nothing to disclose. Dr. Reynolds has nothing to disclose. Dr. Morris has nothing to disclose. Dr. Murthy has nothing to disclose. Dr. Thakur has received personal com...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Merkler, A., Chatterjee, A., Gialdini, G., Reynolds, A., Morris, N., Murthy, S., Thakur, K., Kamel, H. Tags: Infectious Disease: HIV, Syphilis, Borrelia, TB, Cysticercosis, and Other Infections Source Type: research

Cerebrovascular Disease and HIV in Singapore: A Single-Centre Study (P1.325)
Conclusions: Prevalence of CVS risk factors was significant in our population. Stroke in HIV patients may result from other disease mechanisms and carries significant mortality and morbidity. Fever at presentation suggests an infective etiology.Disclosure: Dr. Gan holds stock and/or stock options in a company which sponsored research in which Dr. Gan was involved as an investigator. Dr. Saini has nothing to disclose. Dr. Lee has nothing to disclose. Dr. Ng has nothing to disclose. Dr. Tan has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Gan, E., Saini, M., Lee, C.-C., Ng, O.-T., Tan, K. Tags: HIV/AIDS Source Type: research

An Uncommon Cause for Multiple Cerebral Ischemic Infarcts (P4.344)
Conclusions: Cerebral infarcts due to CM in immunocompetent patients are unusual. However, cryptococcal infection should be considered in atypical stroke manifestations, since early diagnosis and prompt treatment can improve outcome.Disclosure: Dr. Khattak has nothing to disclose. Dr. Desai has nothing to disclose. Dr. Desai has nothing to disclose. Dr. Wise has nothing to disclose. Dr. Moore has nothing to disclose. Dr. Shah has nothing to disclose. Dr. Wilder has nothing to disclose. Dr. Remmel has nothing to disclose. Dr. Liu has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Khattak, J., Desai, M., Desai, D., Wise, E., Moore, K., Shah, J., Wilder, M., Remmel, K., Liu, W. Tags: Cerebrovascular Case Reports Source Type: research

Stroke Subtypes and Risk Factors in Saudi Arabia (P1.124)
CONCLUSION: Non-cardioembolic disease was the overwhelming stroke mechanism in this middle-eastern cohort with only 4[percnt] of patients have cardioembolic stroke, in comparison to roughly 20[percnt] reported in Western cohorts. In part, these differences may be explained by deficient prolonged cardiac monitoring. However the high prevalence of atherothrombotic risk factors and overrepresentation of non-cardioembolic stroke suggests a need to optimize atherothrombotic stroke risk factor management within our populationDisclosure: Dr. Al Harbi has nothing to disclose. Dr. Shoamanesh has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Al Harbi, A., Shoamanesh, A. Tags: Cerebrovascular Disease: Epidemiology Source Type: research

Brachial Plexus Neuritis as Presenting Manifestation of Disseminated Coccidioidomycosis. (P6.323)
CONCLUSIONS:This is the first reported case of coccidioidomycosis presenting with PNS involvement. Both remote inflammatory changes and direct local fungal invasion noted in this case highlight the wide spectrum of clinico-pathological presentations seen in coccidioidomycosis infection. As this fungal disease is identified with increasing frequency, clinicians should be aware of its atypical manifestations. Study Supported by: Disclosure: Dr. Shah has nothing to disclose. Dr. Liao has nothing to disclose. Dr. Shanina has nothing to disclose. Dr. Smith has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Shah, R., Liao, B., Shanina, E., Smith, G. Tags: Fungi, Parasites, and Other Infectious Disorders Source Type: research

A Case Report of Rheumatoid Meningitis, an unusual complication of Rheumatoid Arthritis (P4.056)
CONCLUSIONS: Rheumatoid Meningitis is an extremely uncommon complication of Rheumatoid Arthritis. Initial presentations can vary from altered mental status (most common), cranial neuropathies, hemiparesis/paraparesis, seizure, headache and very rarely stroke like symptoms. This patient with Rheumatoid Arthritis presented with multiple stroke like episodes, lepomeningeal enhancement. Diagnosis was established on the basis of Imaging and Histopathology after excluding other potential causes of granulomatous meningitis. Study Supported by: Not applicableDisclosure: Dr. roy has nothing to disclose. Dr. Brink has nothing to dis...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Roy, B., Brink, J., Bakradze, E., Al Zahmi, F., Uphoff, D., Silverman, I. Tags: MS and CNS Inflammatory Diseases: CNS Inflammatory Diseases and Differential Diagnosis Source Type: research

Predictors of Poor Outcome in Bacterial Meningitis: Retrospective Analysis of Nationwide Inpatient Sample (P5.046)
CONCLUSIONS: In this retrospective study, every decade increase in age, teaching hospital status and development of complications like hydrocephalus, ischemic stroke, seizures, intracranial abscess and respiratory failure were predictors of poor outcome. Every calendar year increase was a negative predictor of poor outcome. Study Supported by:Disclosure: Dr. Dharaiya has nothing to disclose. Dr. Modi has nothing to disclose. Dr. Maraka has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Dharaiya, D., Modi, S., Maraka, S. Tags: Neuroepidemiology: Headache, Global Health, and Infectious Disease Source Type: research

Mortality Predictors in Bacterial Meningitis Patients who developed Hydrocephalus (P5.050)
CONCLUSIONS: In this retrospective analysis, we found that every decade increase in age, ischemic stroke, respiratory failure and requirement of ventriculostomy were significant predictors of mortality in patients of bacterial meningitis who developed hydrocephalus. Study Supported by:Disclosure: Dr. Irshad has nothing to disclose. Dr. Modi has nothing to disclose. Dr. Naqvi has nothing to disclose. Dr. Dharaiya has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Irshad, K., Modi, S., Naqvi, I., Dharaiya, D. Tags: Neuroepidemiology: Headache, Global Health, and Infectious Disease Source Type: research

Timing and number of minor infections as risk factors for childhood arterial ischemic stroke
Conclusions: Minor infections appear to have a strong but short-lived effect on pediatric stroke risk, while cumulative burden of infection had no effect. Proposed mechanisms for the link between minor infection and stroke in adults include an inflammatory-mediated prothrombotic state and chronic endothelial injury. The transient effect of infection in children may suggest a greater role for a prothrombotic mechanism.
Source: Neurology - September 1, 2014 Category: Neurology Authors: Hills, N. K., Sidney, S., Fullerton, H. J. Tags: Childhood stroke, All Infections, Pediatric stroke; see Cerebrovascular Disease/ Childhood stroke, Case control studies ARTICLE Source Type: research

NeurologicManifestations of Neglected Tropical Diseases (P4.295)
CONCLUSIONS: Neurological manifestations of NTDs cause significant morbidity and mortality, although data are limited. The evidence for treatments of neurologic complications is limited for most NTDs. Increased awareness of neurologic manifestations of NTDs can promote early identification and treatment, thereby contributing to ongoing elimination and eradication campaigns.Study Supported by: NADisclosure: Dr. Raibagkar has nothing to disclose. Dr. Berkowitz has received royalty payments from Medmaster and Oxford University Press. Dr. Pritt has nothing to disclose. Dr. Headley-Whyte has nothing to disclose. Dr. Mateen has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Raibagkar, P., Berkowitz, A., Pritt, B., Headley-Whyte, E. T., Mateen, F. Tags: Global Health and Infection Source Type: research

The Risk of Large-Artery Atherosclerotic Stroke is Proportionally Greater than Cardioembolic Stroke in HIV-Infected Individuals Compared to HIV-Uninfected Controls (P4.304)
CONCLUSIONS: HIV-infected individuals with well-controlled infection may be at proportionally greater risk for large artery atherosclerotic versus cardioembolic stroke compared to uninfected individuals. Additional studies are warranted to confirm this association and explore potential mechanisms underlying this difference, including the role of chronic inflammation.Disclosure: Dr. Price has received personal compensation for activities with Abbott Laboratories as a speaker. Dr. Hsue has nothing to disclose. Dr. Kim has received research support from SanBio, Inc.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Chow, F., Price, R., Hsue, P., Kim, A. Tags: NeuroAIDS Source Type: research

The Risk of Large-Artery Atherosclerotic Stroke is Proportionally Greater than Cardioembolic Stroke in HIV-Infected Individuals Compared to HIV-Uninfected Controls (I10-1.003)
CONCLUSIONS: HIV-infected individuals with well-controlled infection may be at proportionally greater risk for large artery atherosclerotic versus cardioembolic stroke compared to uninfected individuals. Additional studies are warranted to confirm this association and explore potential mechanisms underlying this difference, including the role of chronic inflammation.Disclosure: Dr. Price has received personal compensation for activities with Abbott Laboratories as a speaker. Dr. Hsue has nothing to disclose. Dr. Kim has received research support from SanBio, Inc.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Chow, F., Price, R., Hsue, P., Kim, A. Tags: The Global Burden of Neurological Diseases Poster Presentations Source Type: research

Predictive Factors of Central Nervous Infection: Prospective Evaluation of 124 Cases with Suspicion of Meningitis. (P2.303)
Discussion and conclusions: The presence of meningeal signs, hypoglucorraquia and low PH in CSF are the most suggestive findings of meningitis, when compared to fever, mental status changes or other variables. Initial CSF image should include the application of constrast when possible.Disclosure: Dr. Trevino has nothing to disclose. Dr. Gonzalez Duarte has nothing to disclose. Dr. Avila-Funes has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Trevino, I., Gonzalez Duarte, M. A., Avila-Funes, A. Tags: CNS Infectious Disease: Miscellaneous Source Type: research

How experienced community neurologists make diagnoses during clinical encounters
We describe 3 core domains of diagnosis: 1) clinical (C), 2) laboratory and electrodiagnostics (L), and 3) neuroimaging (N). Neurologists were uniform in their practices across these domains except within the clinical domain, where the physical examination varied considerably among clinicians. All neurologists coordinated findings from the 3 domains to arrive at a final diagnosis. This practice of coordination varied across common disease categories (e.g., meningitis vs dementia). To codify this variance, we developed a provisional model of diagnostic practice derived from the data consisting of a 3-point coordinate shorth...
Source: Neurology - October 14, 2013 Category: Neurology Authors: Dhand, A., Engstrom, J., Dhaliwal, G. Tags: Cost effectiveness/economic, Decision analysis, All Clinical Neurology, Methods of education CONTEMPORARY ISSUES Source Type: research

Adjunctive dexamethasone in adults with meningococcal meningitis
In the article by Heckenberg et al.,1 the authors conclude that dexamethasone did not similarly improve the unfavorable outcome in meningococcal meningitis as was seen in their previous pneumococcal cohort study.2 The difference in the incidence of meningitis-related stroke between these meningitis populations may explain the difference in the cohorts' Glasgow Outcome Scale results.
Source: Neurology - May 6, 2013 Category: Neurology Authors: Boelman, C. G., Brouwer, M. C., van de Beek, D. Tags: WRITECLICK: EDITOR ' S CHOICE Source Type: research