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Will unpredictable side effects dim the promise of new Alzheimer ’s drugs?
A sea change is underway in the treatment of Alzheimer’s disease, where for the first time a drug that targets the disease’s pathology and clearly slows cognitive decline has hit the U.S. market. A related therapy will likely be approved in the coming months. As many neurologists, patients, and brain scientists celebrate, they’re also nervously eyeing complications from treatment: brain swelling and bleeding, which in clinical trials affected up to about one-third of patients and ranged from asymptomatic to fatal. The side effect—amyloid-related imaging abnormalities, or ARIA—remains mysterious. “We don’...
Source: Science of Aging Knowledge Environment - August 2, 2023 Category: Geriatrics Source Type: research

Erectile dysfunction, vascular risk, and cognitive performance in late middle age.
Vascular disease is the most common etiology of erectile dysfunction (ED). Men with ED are at a 65% increased relative risk of developing coronary heart disease and a 43% increased risk of stroke within 10 years. Vascular disease is associated with cognitive impairment; ED—an overt manifestation of vascular dysfunction—could also signal early compromised cognition. We sought to determine whether cognitive differences existed between men with ED and healthy peers. Our sample consisted of 651 men (ages 51–60 years) from the Vietnam Era Twin Study of Aging. ED was associated with poorer cognitive performance, particular...
Source: Psychology and Aging - March 24, 2014 Category: Geriatrics Authors: Moore, Caitlin S.; Grant, Michael D.; Zink, Tyler A.; Panizzon, Matthew S.; Franz, Carol E.; Logue, Mark W.; Hauger, Richard L.; Kremen, William S.; Lyons, Michael J. Source Type: research

Long Covid is a ‘national crisis.’ So why are grants taking so long to get?
Some content has been removed for formatting reasons. Please view the original article for the best reading experience. David Putrino, a neurophysiologist at the Icahn School of Medicine at Mount Sinai, labored through his holiday last Christmas to write a grant application for urgently needed Long Covid research. With colleagues, he hoped to tap into $1.15 billion in funding that Congress granted the National Institutes of Health (NIH) in 2020, as Long Covid emerged as a major public health problem. NIH had solicited grant applications in December 2021, just weeks before their January due date. The agency said it pla...
Source: Science of Aging Knowledge Environment - June 10, 2022 Category: Geriatrics Source Type: research

NIH launches grant program aimed at closing the funding rate gap between Black and white investigators
After having one idea batted down last year, some National Institutes of Health (NIH) institutes are taking a new tack to bolster the success rate of Black scientists and researchers from other underrepresented groups seeking research grants. A program aiming to diversify the NIH workforce could award up to $20 million a year to neuroscience, drug abuse, and mental health investigators from minority groups. The program will create a new class of NIH’s standard R01 research grant designed to “encourage a more diverse pool of PIs [principal investigators],” said Walter Koroshetz, director of the National Institute...
Source: Science of Aging Knowledge Environment - June 17, 2022 Category: Geriatrics Source Type: research

NIH ’s vaunted program for solving puzzling medical cases is running out of money
Ten years ago, an athletic 12-year-old from Affton, Missouri, named Mitchell Herndon began to experience muscle weakness that eventually led to him using a wheelchair. After years of visits to specialists failed to diagnose his neurological symptoms, he enrolled in a National Institutes of Health (NIH)-funded program that studies patients with debilitating mystery diseases. Researchers eventually found an explanation for Mitchell’s condition: a mutated gene that causes certain brain cells to produce an overactive protein that leads to neuron damage. Mitchell died 3 years ago at age 19. Since then, 14 more people hav...
Source: Science of Aging Knowledge Environment - June 27, 2022 Category: Geriatrics Source Type: research