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Knock-out of a mitochondrial sirtuin protects neurons from degeneration in < i > Caenorhabditis elegans < /i >
by Rachele Sangaletti, Massimo D ’Amico, Jeff Grant, David Della-Morte, Laura Bianchi Sirtuins are NAD⁺-dependent deacetylases, lipoamidases, and ADP-ribosyltransferases that link cellular metabolism to multiple intracellular pathways that influence processes as diverse as cell survival, longevity, and cancer growth. Sirtuins influence the extent of neuronal death in stroke. Howe ver, different sirtuins appear to have opposite roles in neuronal protection. InCaenorhabditis elegans, we found that knock-out of mitochondrial sirtuinsir-2.3, homologous to mammalian SIRT4, is protective in both chemical ischemia and hypera...
Source: PLoS Genetics - August 18, 2017 Category: Genetics & Stem Cells Authors: Rachele Sangaletti Source Type: research