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Specialty: Cardiology
Drug: Toprol
Procedure: Ultrasound
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Total 1 results found since Jan 2013.
Heart rate changes mediate the embryotoxic effect of antiarrhythmic drugs in the chick embryo
A significant increase in cardiovascular medication use during pregnancy occurred in recent years. Only limited evidence on safety profiles is available, and little is known about the mechanisms of adverse effect on the fetus. We hypothesized that drug-induced bradycardia is the leading mechanism of developmental toxicity. Embryotoxicity was tested in ovo after administration of various doses of metoprolol, carvedilol, or ivabradine. Embryonic day (ED) 4 and 8 chick embryos were studied by video microscopy and ultrasound biomicroscopy ex ovo after intraamniotic injection of the drug for a period of 30 min. Stroke volume wa...
Source: AJP: Heart and Circulatory Physiology - March 15, 2013 Category: Cardiology Authors: Kockova, R., Svatunkova, J., Novotny, J., Hejnova, L., Ostadal, B., Sedmera, D. Tags: INTEGRATIVE CARDIOVASCULAR PHYSIOLOGY AND PATHOPHYSIOLOGY Source Type: research
