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Dual Gate-Controlled Therapeutics for Overcoming Bacterium-Induced Drug Resistance and Potentiating Cancer Immunotherapy
Angew Chem Int Ed Engl. 2021 Mar 26. doi: 10.1002/anie.202102059. Online ahead of print.ABSTRACTThe presence of bacteria in the tumor can cause cancer resistance to chemotherapeutics. To fight against bacterium-induced drug resistance, herein we design self-traceable nanoreservoirs that are simultaneously loaded with gemcitabine and antibiotics ciprofloxacin and are decorated with hyaluronic acid for active tumor targeting. The nanoreservoirs have a pH-sensitive gate and an enzyme-responsive gate that can be opened in the acidic and hyaluronidase-abundant tumor microenvironment to control drug release rates. Moreover, the ...
Source: Angewandte Chemie - March 26, 2021 Category: Chemistry Authors: Yanli Zhao Xiaodong Zhang Xiaokai Chen Yuxin Guo Ge Gao Dongdong Wang Yinglong Wu Jiawei Liu Gaolin Liang Fu-Gen Wu Source Type: research