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Source: J Biochem Mol Biol
Drug: Cipro
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Detection of antistaphylococcal and toxic compounds by biological assay systems developed with a reporter Staphylococcus aureus strain harboring a heat inducible promoter - lacZ transcriptional fusion
J Biochem Mol Biol. 2007 Nov 30;40(6):936-43. doi: 10.5483/bmbrep.2007.40.6.936.ABSTRACTPreviously it was reported that promoter of groES-groEL operon of Staphylococcus aureus is induced by various cell-wall active antibiotics. In order to exploit the above promoter for identifying novel antistaphylococcal drugs, we have cloned the promoter containing region (P(g)) of groES-groEL operon of S. aureus Newman and found that the above promoter is induced by sublethal concentrations of many antibiotics including cell-wall active antibiotics. A reporter S. aureus RN4220 strain (designated SAU006) was constructed by inserting the...
Source: J Biochem Mol Biol - December 1, 2007 Category: Molecular Biology Authors: Palas Kumar Chanda Tridib Ganguly Malabika Das Chia Yen Lee Thanh T Luong Subrata Sau Source Type: research
