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Infectious Disease: Ebola
Drug: Tamoxifen

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Total 4 results found since Jan 2013.

Selective estrogen receptor modulators limit alphavirus infection by targeting the viral capping enzyme nsP1
Antimicrob Agents Chemother. 2022 Jan 18:AAC0194321. doi: 10.1128/AAC.01943-21. Online ahead of print.ABSTRACTAlphaviruses cause animal or human diseases that are characterized by febrile illness, debilitating arthralgia, or encephalitis. Selective estrogen receptor modulators (SERMs), a class of FDA-approved drugs, have been shown to possess antiviral activities against multiple viruses, including Hepatitis C virus, Ebola virus, dengue virus, and vesicular stomatitis virus. Here, we evaluated three SERM compounds, namely 4-hydroxytamoxifen, tamoxifen, and clomifene, for plausible antiviral properties against two medically...
Source: Antimicrobial Agents and Chemotherapy - January 18, 2022 Category: Microbiology Authors: Rajat Mudgal Chandrima Bharadwaj Aakriti Dubey Shweta Choudhary Perumal Nagarajan Megha Aggarwal Yashika Ratra Soumen Basak Shailly Tomar Source Type: research