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Source: Bioinformation
Drug: Tamoxifen
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Total 33 results found since Jan 2013.
Molecular docking analysis of the tumor protein beta arrestin-1 with oxadiazole compounds
Bioinformation. 2023 Jan 31;19(1):111-116. doi: 10.6026/97320630019111. eCollection 2023.ABSTRACTBeta arrestins are a family of adaptor proteins that help in the regulation of signaling and trafficking of various G protein coupled receptors (GPCRs). Six oxadiazole derivatives taken from literature are analyzed for anti-cancer properties. The toxicity profiles of all the drugs were similar to Tamoxifen used as control. Data shows that compounds 2, 4, and 6 exhibited comparably significant molecular interactions with the cancerous protein for further consideration.PMID:37720289 | PMC:PMC10504516 | DOI:10.6026/97320630019111
Source: Bioinformation - September 18, 2023 Category: Bioinformatics Authors: Vipra Sharma Gayathri Rengasamy Surya Sekaran Kavitha Sankaran Vishnu Priya Veeraraghavan Rajalakshmanan Eswaramoorthy Source Type: research
Molecular docking analysis of phytochemicals with estrogen receptor alpha
Bioinformation. 2022 Aug 31;18(8):697-702. doi: 10.6026/97320630018697. eCollection 2022.ABSTRACTBreast cancer (BC) is linked to estrogen receptor alpha (ER-α) positive. Tamoxifen and other estrogen selective modulators have proven to be beneficial in slowing the progression of ER-α BC. However, tamoxifen resistance emerges as a result of long-term treatment and cancer development. Therefore, it is of interest to document data on the molecular docking analysis of phytochemicals targeting with Estrogen Receptor-alpha. The screening of the phytochemicals from the ZINC database (a total of 87133 compounds) against ER-α pro...
Source: Bioinformation - June 16, 2023 Category: Bioinformatics Authors: Misbahuddin M Rafeeq Source Type: research
