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Source: Canadian Journal of Veterinary Research
Drug: Dexamethasone
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Long-term < em > in-vitro < /em > glucocorticoid treatment induces glucocorticoid resistance in canine mast cell tumors
In conclusion, glucocorticoid-resistant canine MCT cell lines have been established that are derived from glucocorticoid-sensitive cell lines. These cell lines suggest that multiple mechanisms contribute to glucocorticoid resistance in canine MCT cells. The mechanisms of glucocorticoid resistance after long-term treatment can be further investigated using these cell lines and a novel therapeutic strategy for glucocorticoid-resistant canine MCT cells can be developed.PMID:34602735 | PMC:PMC8451708
Source: Canadian Journal of Veterinary Research - October 4, 2021 Category: Veterinary Research Authors: Akira Matsuda Source Type: research
